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Analytical SFC


The new JASCO SF-4000 integrated Analytical SFC system has been developed for all aspects of analytical SFC; including routine separation, method development and small scale preparation of samples at the mg scale. With a simple intuitive software and robust engineering, the JASCO SFC system is a powerful tool for analytical separation

The SF-4000 Analytical SFC system comprises:

PU-4380 or 4385 CO2 pump

The PU-4380/4385-CO2 peltier temperature stabilized pump ensures the optimum conditions for pumping liquid CO2, there is no requirement for complicated pretreatment of CO2 and no need for a chiller for cooling the pumps heads. Simply supply low cost beverage grade CO2.

Modifier pumps

Choose either one or two PU-4380/4385 modifier pumps to add to the system with optional 6 or 12 solvent selection for method development.

Column temperature control

Peltier stabilized CO-4060 column oven for accurate control (from below the CO2 critical point up to 100 °C) with large space to accommodate six 4.6mm or 10mm columns (up to 300mm length), with optional column switching. Use 2 ovens for different temperature zones and for multiple column options for chiral and achiral screening.

Back pressure regulator

The BP-4080 remains the best solution for maintaining supercritical conditions with pressure fluctuations as low as 1.5 psi peak to peak. Dynamic control enables modifier gradients without changes to back pressure. Response is fast and accurate ensuring stable baselines even for trace level analysis.


The SF-4000 system offers the widest selection of detection available for Analytical SFC.


The SF-4000 system offers two UV-Vis detectors: the UV-4070 for single wavelength 190 to 900nm, and UV-4075 for 190-600 nm.

Photometric Diode Array PDA

The SF-4000 system is equipped with MD-4010, a 1024-element diode array for high sensitivity, trace analysis and component identification.


The CD-4095 circular dichroism detector is the only chiral detector compatible with SFC and provides positive confirmation of enantiomeric separation. It can also be used to drive chiral directed prep SFC.


ELSD and FID detection can be used by splitting a portion of flow to inlet of the detector; these detectors are great for material that have no absorbing chromophore such as in petrochemical or pharmaceutical analysis.

Mass Spectrometry Detection with SFC

The analytical SFC can be used with virtually any mass spectrometer working with ESI, APCI or APPI interface.

The SF-4000 system is completely controlled using the ChromNav data system - offering simple control for routine analytical separation through to complex method development with a range of enhanced reporting capabilities. Full GxP compliance and 21 CFR part 11.


Kontakt: Mikael Alfredsson på Göteborgskontoret, 0709-119309
              Mats Grapne Askfelt på Stockholms-kontoret, 0709-119301

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