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Classic Glassware

The flexiWAVE has been thought and engineered as a microwave platform where all types of commonly used glassware could be used. This clearly results in a very flexible system, with a wide range of applications capabilities. The Classic Glassware setup, for instance, provides the suitable apparatus for a full reaction optimization, for research or teaching purposes. It allows the chemists to perform synthetic reactions under reflux and, in this manner, any chemical reaction currently carried out with hot plates, heating mantles or oil baths, could be rapidly improved by adopting microwave technology.

Milestone flexiWAVE classic_glassware
Milestone FlexiWAVE formula_glassare

Rapid preparation of pyranoquinolines using microwave dielectric heating in combination with fractional product distillation
T Razzaq, C.O. Kappe, Tetrahedron Letters 2007, 48, 2513-2517


Stubborn reactions are typically carried out in refluxing conditions, using high boiling solvents such as xylenes, 1,2-dichlorobenzene and N-methyl pyrrolidone. High boiling solvents are then difficult to remove upon workup, especially as reaction scale increases. The High-Pressure setup is capable of replacing reflux devices, moving from high boiling solvents to low boiling solvents. Moreover, high temperature reactions (up to 300 °C) are allowed. The benefits are well known and documented in terms of easier work-up and products purity. Up to 15 high-pressure vessels may be used simultaneously for parallel synthesis.

Milestone flexiWAVE high_pressure

Milestone flexiWAVE formula_highpressure

Design and Synthesis of a g1b8-Cyclodextrin Oligomer: A New Platform with Potential Application as a Dendrimeric Multicarrier
A. Barge et al., Chem. Eur. J. 2013, 19, 12086-12092


Heating heterogeneous reaction mixtures, thick media or solid phase systems suffers of inhomogeneous temperature distribution and stirring difficulties using conventional microwave instruments. The innovative Solid-Phase setup offers the unique capability of physically rotate the reaction vessel, to achieve very homogenous bulk heating of slurries, viscous and solid reaction mixtures media. The reaction temperature is controlled by a contact-less infrared sensor. Furthermore, the Solid-Phase setup allows operations under normal atmosphere, inert gas, and vacuum. Functionalization and modifications of materials, polycondensation, coating, dehydration of natural oils are some of the most common area of application.

Milestone FlexiWAVE solid_phase
Milestone flexiWAVE formula_solidphase

Efficient Green Protocols for Preparation of Highly Functionalized B-Cyclodextrin-Grafted Silica
K. Martina et al., ACS Sustainable Chem. Eng. 2014, 2, 2595-2603

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