Unmatched flexibility when it comes to separation on several columns and detection techniques

Jasco Analytical SFC


Unmatched flexibility when it comes to separation on several columns and detection techniques

The SFC-4000 analytical SFC is extremely flexible, and with multiple solvent options enables rapid screening of a range of columns using different solvent conditions completely automatically.

Brochure

Jasco Analytical SFC

The SFC-4000 has an option for up to three column ovens each with ten full sized columns; each with separate temperature control, great for combining chiral and achiral SFC in a single system. Take advantage of a PDA detector combined with the CD-4095 chiral detector to work up fast analytical methods for direct scale-up to semi-prep and prep separations of chiral compounds.
  • ● Column ID 3 mm
  • ● CO2 Flow Rate 0,2 - 10 mL
  • ● Each system component is completely stackable into a modest height
  • ● The system is fully integrated with complete system monitoring
  • ● All user replaceable components are accessible through the front panel
  • ● Vertical leak/drain system to channel away solvent
  • ● Integrated earthquake securing option

Product Specialist

Mats Grapne

"More than 30 years experience in the field of HPLC, Spectroscopy and other analytical equipments. Contact me if you have questions or need a quotation"

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0709-119301

PU-4380 COPump

The PU-4380-CO2 Peltier temperature stabilized pump ensures the optimum conditions for pumping liquid CO2, there is no requirement for complicated pretreatment of CO2 and a chiller is not required for cooling the pump heads. Automatic stop valves control the input and output of CO2.
  • Modifier Pumps

    The PU-4180 modifier pump with optional 6 or 10 solvent selection for method development.
  • Column Temperature Control

    CO-4060 column oven for accurate control (from below ambient up to 80 degC) with large space to accommodate six 4.6mm or 10mm columns (up to 300mm length), with optional column switching. The system can be configured with up to 3 ovens for different temperature zones and for multiple column options for chiral and achiral screening. The larger CO-4065 with internal column switching can be used with analytical and prep columns up to 3cm ID.
  • Back Pressure Regulator

    The BP-4380 precision back pressure regulator is the best solution for maintaining super critical conditions with pressure fluctuations as low as 1.5 psi peak-to-peak. Dynamic control allows modifier gradients without changes in the back pressure applied to the column. Response is fast and accurate ensuring stable baselines even for trace level analysis.
  • Detection

    The SFC-4000 system has the widest selection of detectors available for Analytical SFC. And for applications requiring the utmost sensitivity, JASCO has designed the first high pressure flow cell designed for our fluorescence detectors making them compatible with SFC.
  • UV-Visible

    UV-4070/75 for dual wavelength 190 to 600nm (or 900nm).
  • Photometric Diode Array PDA

    MD-4010, a 1024-element diode array for high sensitivity, trace analysis and component identification.

  • Chiral

    The CD-4095 circular dichroism detector is the only chiral detector compatible with SFC and provides positive confirmation of enantiomeric separation. It can also be used to control chiral directed prep SFC.The CD-4095 circular dichroism detector is the only chiral detector compatible with SFC and provides positive confirmation of enantiomeric separation. It can also be used to control chiral directed prep SFC.

  • ELSD and FID

    ELSD and FID detection can be used by splitting a portion of flow to the inlet of the detector; these detectors are ideal for material that has no  chromophore such as in petrochemical or pharmaceutical analysis.ELSD and FID detection can be used by splitting a portion of flow to the inlet of the detector; these detectors are ideal for material that has no  chromophore such as in petrochemical or pharmaceutical analysis.

  • Single Quadrapole Mass Spectrometer Detection with SFC

    The SF-4000 analytical can be used with virtually any mass spectrometer working with ESI, APCI or APPI interface.The SF-4000 analytical can be used with virtually any mass spectrometer working with ESI, APCI or APPI interface.

  • Instrument Control and Data Acquisition

    The SFC-4000 system includes the ChromNAV data system – offering simple control for routine analytical separation through to complex method development with a range of enhanced reporting capabilities. Full GxP compliance and 21 CFR part 11.The SFC-4000 system includes the ChromNAV data system – offering simple control for routine analytical separation through to complex method development with a range of enhanced reporting capabilities. Full GxP compliance and 21 CFR part 11.

SFC-4000 Analytical SFC System Applications

Method Development
With up to 2 modifier pumps and 6 or 10 solvent selection units, modifier selection is very flexible and enables rapid screening of a range of columns using different solvent conditions completely automatically. The SFC-4000 has an option for up to 3 column ovens each with up to 10 full sized columns with separate temperature control, great for combining chiral and achiral SFC in a single system.

Take advantage of the MD-4010 PDA detector combined with the CD-4095 chiral detector to work up fast analytical methods for direct scale-up to semi-prep and prep separations.

Simple Analytical
SFC-4000 Analytical SFC system operates with flow rates between 0.5 to 7mL/min (Liquid CO2).

Small Scale Prep
Using 4.6mm columns with a choice of either 6 or 8 way fraction valves or the new open bed fraction collector with MCS 6 micro-cyclone collection system (patented), the SFC-4000 system is the ideal choice for small scale (sub mg) preparation using analytical SFC.

For larger scale purification and method development

Jasco Semi-Preparative SFC


For larger scale purification and method development

The semi-prep SFC has capacity for larger scale purification but can still be used for analytical scale method development.

Brochure

Jasco Semi-Preparative SFC

The system is optimized for 10mm and 20mm ID columns. The open-bed fraction collector can be triggered on time, threshold or slope based on signals from up to 4 different detectors signals including UV, PDA, fluorescence, CD and/or MS. The macro cyclone separators provide simple gas-liquid separation for excellent fraction recoveries typically greater than 95%. Fractions can be collected using an open bed fraction collector or an 8-way valve.
  • ● Column ID 4,6 - 20 mm
  • ● CO2 Flow Rate 3 - 50 mL
  • ● The system is fully integrated with complete system monitoring
  • ● All user replaceable components are accessible through the front panel
  • ● Vertical leak/drain system to channel away solvent
  • ● Integrated earthquake securing option

Product Specialist

Mats Grapne

"More than 30 years experience in the field of HPLC, Spectroscopy and other analytical equipments. Contact me if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
0709-119301
  • Semi-Preparative Flow Rates

    Using columns for 10 mm and 20mm ID, the semi-preparative SFC System can be used for separation and purification  of 10 to 100 grams of sample material.
  • Typical Purification Range

    Semi-preparative flow rates from 3mL/min to 50mL/min for purification of up to 100g of sample.
  • Column Switching

    Six or ten column switching for automatic selection.
  • Solvent Switching

    Six or ten modifier solvent selection for method development.
  • High-Capacity Column Oven

    High capacity column oven for up to three 20mm columns.
  • High Recovery Rate

    Patented individual MCS MicroCyclone fraction collection system for sample collection without cross contamination.
  • Powerful Software

    ChromNav for simple control with powerful fractionation algorithms.
  • Wide Range of Detectors

    Wide range of detectors including UV-Visible, PDA, Mass Spec, ELSD,  FID and CD (circular dichroism for chiral applications). For applications that require the utmost sensitivity, JASCO has designed the first high pressure flow cell designed for the FP-4020 fluorescence detector making it compatible with SFC.
  • High-Throughput Fraction Collection System

    Fraction collection with open bed fraction collector.
  • Dynamic Back Pressure Regulator

    Patented dynamic back pressure regulator for accurate control of pressure for accurate and reproducible separations.

SFC-4000 Series

Back Pressure Regulator
The BP-4380 precision back pressure regulator is the best solution for maintaining super critical conditions with pressure fluctuations as low as 1.5 psi peak-to-peak. Dynamic control allows modifier gradients without changes in the back pressure applied to the column. Response is fast and accurate ensuring stable baselines even for trace level analysis.
Modifier Pumps
The PU-4180 modifier pump with optional 6 or 10 solvent selection for method development.
Column Temperature Control
CO-4060 column oven for accurate control (from below ambient up to 80 degC) with large space to accommodate six 4.6mm or 10mm columns (up to 300mm length), with optional column switching. The system can be configured with up to 3 ovens for different temperature zones and for multiple column options for chiral and achiral screening. The larger CO-4065 with internal column switching can be used with analytical and prep columns up to 3cm ID.
Detection
The SFC-4000 system has the widest selection of detectors available for Analytical SFC. And for applications requiring the utmost sensitivity, JASCO has designed the first high pressure flow cell designed for our fluorescence detectors making them compatible with SFC.

Optimized
JASCO has been developing packed column SFC and SFE systems for more than 30 years; this evolution has resulted in a user-friendly, robust and powerful SFC-4000 Series.

For large scale purification

Jasco Preparative SFC


For large scale purification

The SFC-4000 Prep system is designed for large scale throughput with 21 mm or 30 mm columns to maximum sample purification. The system is versatile enough to be used for smaller scale prep using 10 mm columns. 

Brochure

SFC-4000 Prep system

Interchangeable modifier pumps can be configured to give highly accurate modifier compositions. Jasco SF-NAV provides complete integrated control for flow rate, temperature, sample injection and fractionation.
  • ● Column ID; 10, 20 or 30mm
  • ● CO2 Flow Rate 5.0 - 150mL
  • ● Each system component is completely stackable into a modest height
  • ● The system is fully integrated with complete system monitoring
  • ● All user replaceable components are accessible through the front panel
  • ● Vertical leak/drain system to channel away solvent
  • ● Integrated earthquake securing option

Product Specialist

Mats Grapne

"More than 30 years experience in the field of HPLC, Spectroscopy and other analytical equipments. Contact me if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
0709-119301
  • Fast CO2 Delivery

    Preparative scale CO2 delivery of up to 150mL/min, or up to 200mL when combined with a modifier co-solvent.
  • Sample separation for Chiral & Achiral

    The SFC-4000 Prep system is excellent for both Chiral and Achiral sample preparation.
  • Powerful SFC Management Tool

    Using SF-Nav software the SFC-4000 Prep can be used with a wide variety of fraction collection methods, including time window, slope and/or threshold, to achieve high throughput stack injection.Using SF-Nav software the SFC-4000 Prep can be used with a wide variety of fraction collection methods, including time window, slope and/or threshold, to achieve high throughput stack injection.
  • Complete Audit trail to monitor campaigns

    SF-NAV controls your campaign; monitor the individual chromatograms, complete sets of stacked injections, pressure and temperature profiles throughout the system.SF-NAV controls your campaign; monitor the individual chromatograms, complete sets of stacked injections, pressure and temperature profiles throughout the system.
  • High-Throughput Sample

    Several fraction collection regimes for use with larger sample bottles for larger scale purification.
  • Accurate Chromatography with Large Volume Injections

    SFC-4000 uses the Patented DLI (Dual Line Injection) to ensure excellent chromatography when making large volume injections.SFC-4000 uses the Patented DLI (Dual Line Injection) to ensure excellent chromatography when making large volume injections.
  • 8 Fraction Sample Collection Unit

    The SFC-4000 fraction collection unit includes the patented dynamic back pressure regulator, 8 individual heated cyclone separators with a separate waste line. Fraction control allow sequential or stacked injection, with the option to collect the fractions between peaks to ensure there is no sample loss. Recoveries are typically in the region 95% or better with negligible cross contamination between fractions.
  • Widest Range of Detection Schemes

    The SFC-4000 Prep system can be used with a single detector or combination of detectors to control fractionation, including Mass Spec, UV-Vis, PDA and chiral (Circular Dichroism). And for applications requiring the utmost sensitivity, JASCO has designed the first high pressure flow cell designed for our fluorescence detectors making them compatible with SFC.The SFC-4000 Prep system can be used with a single detector or combination of detectors to control fractionation, including Mass Spec, UV-Vis, PDA and chiral (Circular Dichroism). And for applications requiring the utmost sensitivity, JASCO has designed the first high pressure flow cell designed for our fluorescence detectors making them compatible with SFC.

JASCO SFC System Advantage

Optimized
JASCO has been developing packed column SFC and SFE systems for more than 30 years; this evolution has resulted in a user-friendly, robust and powerful SFC-4000 Series.

Fast Response Back Pressure Regulator
The BP-4340 high-speed dynamic back-pressure regulator ensures an accurate and constant back pressure (typically within a few psi), regardless of flow rate and with virtually no hysteresis. The extremely low dead volume prevents fractions from remixing and precipitation build-up in the flow line.
Wide Range of Detectors
Fluorescence, UV-visible, Photometric Diode Array (PDA) and Chiral optical detectors. Non-optical detectors include FID, ELSD and single-quad mass-spec.
Flexible
All SF-4000 series SFC systems can be used for HPLC – simply switch off the cooling and BPR.
Integrated Modular System
A basic system for each scale can be adapted to suit any application. From modifier selection to column heater type to detector combinations.
Compatible
JASCO SFC systems are compatible with most Mass Spectrometers and offer integrated control with both Advion CMS and Sciex Analyst.
Flexible Configurations
The three individual platforms for analytical, semi-prep and preparative scales can be customized to suit all applications.

Perfect combination of Analytical and Semi-preparative SFC

Jasco Hybrid SFC


Perfect combination of Analytical and Semi-preparative SFC

The SFC Hybrid system crosses the divide between analytical SFC and preparative SFC, offering the best of both techniques.

Brochure

Jasco Hybrid SFC

With flow rates from 1 mL/min up to 20mL/min this system can be used with 4.6mm columns for high quality analytical separations and with 10mm columns for excellent sample isolation and purification.
  • ● Column ID 4,6 mm
  • ● CO2 Flow Rate 0,5 - 20 mL
  • ● The system is fully integrated with complete system monitoring
  • ● All user replaceable components are accessible through the front panel
  • ● Vertical leak/drain system to channel away solvent
  • ● Integrated earthquake securing option

Product Specialist

Mats Grapne

"More than 30 years experience in the field of HPLC, Spectroscopy and other analytical equipments. Contact me if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
0709-119301
  • Analytical to Semi-Preparative Flow Rates

    Using columns from 4.6 to 10 mm ID, the Hybrid SFC System can be used for separation and purification  of up to several 100 mg of sample material.
  • Typical Purification Range

    Analytical and semi-preparative flow rates from 1mL/min to 20mL/min for purification of samples up to 100s of mg.
  • Column Switching

    Six or ten column switching for automatic selection for method development.
  • Solvent Switching

    Six or ten modifier solvent selection for method development.
  • High-Capacity Column Oven

    High capacity column oven for up to ten 10mm columns, with an option for use of up to 3 column ovens for even greater flexibility.
  • High Recovery Rate

    Patented individual MCS MicroCyclone fraction collection system for sample collection without cross contamination.
  • Powerful Software

    ChromNav for simple control with powerful fractionation algorithms.
  • Wide Range of Detectors

    Wide range of detectors including UV-Visible, PDA, Mass Spec, ELSD,  FID and CD (circular dichroism for chiral applications).  For applications that require the utmost sensitivity, JASCO has designed the first high pressure flow cell designed for the FP-4020 fluorescence detector making it compatible with SFC.
  • High-Throughput Fraction Collection System

    Fraction collection with open bed fraction collector.
  • Dynamic Back Pressure Regulator

    Patented dynamic back pressure regulator for accurate control of pressure for accurate and reproducible separations.

SFC-4000 Series

Back Pressure Regulator
The BP-4380 precision back pressure regulator is the best solution for maintaining super critical conditions with pressure fluctuations as low as 1.5 psi peak-to-peak. Dynamic control allows modifier gradients without changes in the back pressure applied to the column. Response is fast and accurate ensuring stable baselines even for trace level analysis.
Modifier Pumps
The PU-4180 modifier pump with optional 6 or 10 solvent selection for method development.
Column Temperature Control
CO-4060 column oven for accurate control (from below ambient up to 80 degC) with large space to accommodate six 4.6mm or 10mm columns (up to 300mm length), with optional column switching. The system can be configured with up to 3 ovens for different temperature zones and for multiple column options for chiral and achiral screening. The larger CO-4065 with internal column switching can be used with analytical and prep columns up to 3cm ID.
Detection
The SFC-4000 system has the widest selection of detectors available for Analytical SFC. And for applications requiring the utmost sensitivity, JASCO has designed the first high pressure flow cell designed for our fluorescence detectors making them compatible with SFC.

Optimized
JASCO has been developing packed column SFC and SFE systems for more than 30 years; this evolution has resulted in a user-friendly, robust and powerful SFC-4000 Series.

KOVALENTS PHILOSOPHY

At Kovalent we strive to establish and develop long-term partnerships with our customers. When we use the word “partnership” we mean that Kovalent becomes an integral part of our customers’ projects, where we are expected to fully understand their application needs. We aim to make Kovalent our customers’ first and natural choice, and this ambition permeates our entire organisation from initial contact to finished and delivered product.

CONTACTS:

Kovalent AB
Hulda Lindgrens gata 6A
421 31 VÄSTRA FRÖLUNDA
Sweden
Phone: +46(0)31-709 81 80
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Org.nr: 556417-2194

SKANDINAVISKA GENETEC AB

Genetec is a member of the same family of companies as Kovalent. Both companies share the same set of values and are in many ways integrated with each other. The main difference between the two companies are their products. Kovalent is involved in system solutions including instrumentation and Genetec is mainly working with consumables. The focus of Genetec is chromatography accessories. You are welcome to visit their state of the art web shop: genetec.se