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Jasco Preparative SFC

For large scale purification

For large scale purification

The SFC-4000 Prep system is designed for large scale throughput with 21 mm or 30 mm columns to maximum sample purification. The system is versatile enough to be used for smaller scale prep using 10 mm columns. 

Brochure

SFC-4000 Prep system

Interchangeable modifier pumps can be configured to give highly accurate modifier compositions. Jasco SF-NAV provides complete integrated control for flow rate, temperature, sample injection and fractionation.
  • ● Column ID; 10, 20 or 30mm
  • ● CO2 Flow Rate 5.0 - 150mL
  • ● Each system component is completely stackable into a modest height
  • ● The system is fully integrated with complete system monitoring
  • ● All user replaceable components are accessible through the front panel
  • ● Vertical leak/drain system to channel away solvent
  • ● Integrated earthquake securing option

Product Specialist

Mats Grapne Kovalent

Mats Grapne

"More than 30 years experience in the field of HPLC, Spectroscopy and other analytical equipments. Contact me if you have questions or need a quotation"

mats.grapne@kovalent.se

08-473 33 40

  • Fast CO2 Delivery

    Preparative scale CO2 delivery of up to 150mL/min, or up to 200mL when combined with a modifier co-solvent.

  • Sample separation for Chiral & Achiral

    The SFC-4000 Prep system is excellent for both Chiral and Achiral sample preparation.

  • Powerful SFC Management Tool

    Using SF-Nav software the SFC-4000 Prep can be used with a wide variety of fraction collection methods, including time window, slope and/or threshold, to achieve high throughput stack injection.Using SF-Nav software the SFC-4000 Prep can be used with a wide variety of fraction collection methods, including time window, slope and/or threshold, to achieve high throughput stack injection.

  • Complete Audit trail to monitor campaigns

    SF-NAV controls your campaign; monitor the individual chromatograms, complete sets of stacked injections, pressure and temperature profiles throughout the system.SF-NAV controls your campaign; monitor the individual chromatograms, complete sets of stacked injections, pressure and temperature profiles throughout the system.

  • High-Throughput Sample

    Several fraction collection regimes for use with larger sample bottles for larger scale purification.

  • Accurate Chromatography with Large Volume Injections

    SFC-4000 uses the Patented DLI (Dual Line Injection) to ensure excellent chromatography when making large volume injections.SFC-4000 uses the Patented DLI (Dual Line Injection) to ensure excellent chromatography when making large volume injections.

  • 8 Fraction Sample Collection Unit

    The SFC-4000 fraction collection unit includes the patented dynamic back pressure regulator, 8 individual heated cyclone separators with a separate waste line. Fraction control allow sequential or stacked injection, with the option to collect the fractions between peaks to ensure there is no sample loss. Recoveries are typically in the region 95% or better with negligible cross contamination between fractions.

  • Widest Range of Detection Schemes

    The SFC-4000 Prep system can be used with a single detector or combination of detectors to control fractionation, including Mass Spec, UV-Vis, PDA and chiral (Circular Dichroism). And for applications requiring the utmost sensitivity, JASCO has designed the first high pressure flow cell designed for our fluorescence detectors making them compatible with SFC.The SFC-4000 Prep system can be used with a single detector or combination of detectors to control fractionation, including Mass Spec, UV-Vis, PDA and chiral (Circular Dichroism). And for applications requiring the utmost sensitivity, JASCO has designed the first high pressure flow cell designed for our fluorescence detectors making them compatible with SFC.

JASCO SFC System Advantage

Optimized
JASCO has been developing packed column SFC and SFE systems for more than 30 years; this evolution has resulted in a user-friendly, robust and powerful SFC-4000 Series.

Fast Response Back Pressure Regulator
The BP-4340 high-speed dynamic back-pressure regulator ensures an accurate and constant back pressure (typically within a few psi), regardless of flow rate and with virtually no hysteresis. The extremely low dead volume prevents fractions from remixing and precipitation build-up in the flow line.
Wide Range of Detectors
Fluorescence, UV-visible, Photometric Diode Array (PDA) and Chiral optical detectors. Non-optical detectors include FID, ELSD and single-quad mass-spec.
Flexible
All SF-4000 series SFC systems can be used for HPLC – simply switch off the cooling and BPR.
Integrated Modular System
A basic system for each scale can be adapted to suit any application. From modifier selection to column heater type to detector combinations.
Compatible
JASCO SFC systems are compatible with most Mass Spectrometers and offer integrated control with both Advion CMS and Sciex Analyst.
Flexible Configurations
The three individual platforms for analytical, semi-prep and preparative scales can be customized to suit all applications.