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Jasco Semi-Preparative SFC

For larger scale purification and method development

For larger scale purification and method development

The semi-prep SFC has capacity for larger scale purification but can still be used for analytical scale method development.

Jasco Semi-Preparative SFC

The system is optimized for 10mm and 20mm ID columns. The open-bed fraction collector can be triggered on time, threshold or slope based on signals from up to 4 different detectors signals including UV, PDA, fluorescence, CD and/or MS. The macro cyclone separators provide simple gas-liquid separation for excellent fraction recoveries typically greater than 95%. Fractions can be collected using an open bed fraction collector or an 8-way valve.

  • ● Column ID 4,6 - 20 mm
  • ● CO2 Flow Rate 3 - 50 mL
  • ● The system is fully integrated with complete system monitoring
  • ● All user replaceable components are accessible through the front panel
  • ● Vertical leak/drain system to channel away solvent
  • ● Integrated earthquake securing option

Product Specialist

Mats Grapne Kovalent

Mats Grapne

"More than 30 years experience in the field of HPLC, Spectroscopy and other analytical equipments. Contact me if you have questions or need a quotation"
  • Semi-Preparative Flow Rates

    Using columns for 10 mm and 20mm ID, the semi-preparative SFC System can be used for separation and purification  of 10 to 100 grams of sample material.
  • Typical Purification Range

    Semi-preparative flow rates from 3mL/min to 50mL/min for purification of up to 100g of sample.
  • Column Switching

    Six or ten column switching for automatic selection.
  • Solvent Switching

    Six or ten modifier solvent selection for method development.
  • High-Capacity Column Oven

    High capacity column oven for up to three 20mm columns.
  • High Recovery Rate

    Patented individual MCS MicroCyclone fraction collection system for sample collection without cross contamination.
  • Powerful Software

    ChromNav for simple control with powerful fractionation algorithms.
  • Wide Range of Detectors

    Wide range of detectors including UV-Visible, PDA, Mass Spec, ELSD,  FID and CD (circular dichroism for chiral applications). For applications that require the utmost sensitivity, JASCO has designed the first high pressure flow cell designed for the FP-4020 fluorescence detector making it compatible with SFC.
  • High-Throughput Fraction Collection System

    Fraction collection with open bed fraction collector.
  • Dynamic Back Pressure Regulator

    Patented dynamic back pressure regulator for accurate control of pressure for accurate and reproducible separations.

SFC-4000 Series

Back Pressure Regulator
The BP-4380 precision back pressure regulator is the best solution for maintaining super critical conditions with pressure fluctuations as low as 1.5 psi peak-to-peak. Dynamic control allows modifier gradients without changes in the back pressure applied to the column. Response is fast and accurate ensuring stable baselines even for trace level analysis.
Modifier Pumps
The PU-4180 modifier pump with optional 6 or 10 solvent selection for method development.
Column Temperature Control
CO-4060 column oven for accurate control (from below ambient up to 80 degC) with large space to accommodate six 4.6mm or 10mm columns (up to 300mm length), with optional column switching. The system can be configured with up to 3 ovens for different temperature zones and for multiple column options for chiral and achiral screening. The larger CO-4065 with internal column switching can be used with analytical and prep columns up to 3cm ID.
The SFC-4000 system has the widest selection of detectors available for Analytical SFC. And for applications requiring the utmost sensitivity, JASCO has designed the first high pressure flow cell designed for our fluorescence detectors making them compatible with SFC.

JASCO has been developing packed column SFC and SFE systems for more than 30 years; this evolution has resulted in a user-friendly, robust and powerful SFC-4000 Series.