• Home
  • Sample preparation

ETHOS EASY is the most advanced yet easy to use microwave digestion platform we have ever manufactured

Ethos Easy


How EASY can microwave sample preparation become?

ETHOS EASY is the most advanced yet easy to use microwave digestion platform we have ever manufactured. It offers a perfect integration between microwave hardware, user interface, digestion sensors and pressure vessels.

Brochure

System description

The range of sample types requesting microwave digester and analysis for trace metals has grown significantly in recent years. At the same time, sample workloads have increased, and turnaround time reduced.
In addition, the development of collision cell ICP-MS has widened its applicability to more complex sample types placing additional demands on microwave acid digestion: its lower detection limits and fast analysis time require lower blank contribution and higher throughput in sample preparation techniques.
In response to these demands, Milestone has developed the new microwave digestion oven ETHOS EASY, specifically designed for closed vessel microwave acid digestion, with full control of all reaction parameters.

  • Safety and reliability: Best microwave hardware, temperature and pressure sensors
  • Performance and throughput:.EasyCONTROL operating software

  • ● Ease of use and control: easyTEMP temperature control and advanced rotor technology

  • ● Expertise and know-how: 30-years experience at your lab with the Milestone Connect
  • ● Flexibility: Rotor-based digestion system for hundreds of applications.

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Rugged, reliable microwave platform

While other manufacturers use molded plastic, Milestone uses 18/8 stainless steel construction throughout which creates the most durable, reliable, and safe microwave system available.

THE LARGEST STAINLESS-STEEL MICROWAVE CAVITY

The microwave cavity has a volume of over 70 liters, the largest currently available. Therefore, digestion rotors with more sample places can be accommodated, incresing both productivity and sample throughput. Secondly, it improves the inherently safety because a larger cavity contains gases escaping from vessels in a more efficient way, in case of a sudden over pressurization.

THE MOST POWERFUL MICROWAVE DIGESTER

The ETHOS UP is equipped with two 950 Watt magnetrons for a total of 1900 Watt. The system additionally employs a rotating diffuser that evenly distributes the microwaves throughout the cavity. High power coupled with this diffuser enable very fast heating of high throughput rotors and the complete digestion of the most difficult samples.

PRESSURE-RESPONSIVE DOOR FOR MAX SAFETY

For additional safety, the ETHOS UP features a full stainless steel door with an innovative opening and self-resealing mechanism. Should there be a sudden over pressurization of the cavity, the door slightly opens for rapid and safe pressure release and the microwave power is instantaneously cut off. Immediately afterwards, the door is pulled back, resealing the microwave cavity.

Sensors for unparalleled digestion control

In a digestion process, the temperature controls the sample decomposition and directly affects digestion quality. Milestone pioneered the use of infrared sensors combined with an in-situ temperature sensor. Today, Milestone innovates again by combining all the benefits of in-situ and infrared sensors into the Milestone easyTEMP, a direct contactless temperature sensor.

Temperature profile of a soil digestion in accordance with US EPA 3051 using the MAXI-44 rotor

Temperature control with easyTEMP

The easyTEMP contactless sensor directly controls the temperature of all samples and solutions, providing accurate temperature feedback to ensure complete digestion in all vessels with superior safety. This technology combines the fast and accurate reading of an in-situ temperature sensor with the flexibility of an infrared sensor.
The ETHOS UP software provides digestion history traceability and temperature measurement for every sample. Temperature diagrams and profiles are displayed in real-time, and can be saved on the ETHOS UP terminal.
In combination with our 'vent-and-reseal' vessel technology, these sensors ensure complete and safe digestions without any loss of volatile compounds.

  • ● Increased ease of use and productivity

  • ● Enhanced control in all vessels

  • ● Fast and accurate temperature measurements

  • ● Superior digestion quality

Smart software to save your time!

Hundreds of applications including all US EPA methods, are preloaded in the Ethos Easy terminal virtually eliminating any need for method development. To further simplify the workflow in the lab the Ethos Up is equipped with a backlit logo that indicate the actual status of the digestion process.

  • ● Hundreds of methods factory installed

  • ● Visual indication of temperature and pressure values

  • ● Methods and runs printed or stored as PDF files

  • ● Easy-to-read, bright, full-color, touchscreen display

  • ● Icon-driven, multi-language software

Rotors

ETHOS UP have all benefits from Ethos Easy plus more!.

Ethos Up


High Performance Microwave Digestion System

The new ETHOS UP is simply the most advanced yet easy to use system for microwave sample preparation we have ever manufactured. It offers a perfect integration between microwave hardware, user interface, digestion sensors and pressure vessels.

Video Presentation

Brochure

System description

The ETHOS UP fully embodies Milestone’s philosophy in microwave sample preparation. Specifically designed for closed vessel microwave acid digestion, it offers productivity, safety, ease of use, connectivity, expertise and application flexibility.The ETHOS UP fully embodies Milestone’s philosophy in microwave sample preparation. Specifically designed for closed vessel microwave acid digestion, it offers productivity, safety, ease of use, connectivity, expertise and application flexibility.Featuring a comprehensive choice of accessories, ETHOS UP microwave digestion system encompasses Milestone’s visionary concept of “Total Microwave Sample Preparation” offering a complete first-class solution for microwave solvent extraction, high-temperature fusion, vacuum evaporation and even organic and inorganic synthesis or protein hydrolysis.
  • Safety and reliability: Best microwave hardware, temperature and pressure sensors
  • Performance and throughput:. easyTEMP temperature control and advanced rotor technology
  • ● Ease of use and control: EasyCONTROL operating software
  • ● Expertise and know-how: 30-years experience at your lab with the Milestone Connect
  • ● Flexibility: Rotor-based digestion system for hundreds of applications.

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Rugged, reliable microwave platform

While other manufacturers use molded plastic, Milestone uses 18/8 stainless steel construction throughout which creates the most durable, reliable, and safe microwave system available.

THE LARGEST STAINLESS-STEEL MICROWAVE CAVITY

The microwave cavity has a volume of over 70 liters, the largest currently available. Therefore, digestion rotors with more sample places can be accommodated, incresing both productivity and sample throughput. Secondly, it improves the inherently safety because a larger cavity contains gases escaping from vessels in a more efficient way, in case of a sudden over pressurization.

THE MOST POWERFUL MICROWAVE DIGESTER

The ETHOS UP is equipped with two 950 Watt magnetrons for a total of 1900 Watt. The system additionally employs a rotating diffuser that evenly distributes the microwaves throughout the cavity. High power coupled with this diffuser enable very fast heating of high throughput rotors and the complete digestion of the most difficult samples.

PRESSURE-RESPONSIVE DOOR FOR MAX SAFETY

For additional safety, the ETHOS UP features a full stainless steel door with an innovative opening and self-resealing mechanism. Should there be a sudden over pressurization of the cavity, the door slightly opens for rapid and safe pressure release and the microwave power is instantaneously cut off. Immediately afterwards, the door is pulled back, resealing the microwave cavity.

LIVE MONITORING WITH MILESTONE SafeVIEW

The ETHOS UP integrates the Milestone safeVIEW, a high definition digital camera interfaced with the instrument terminal. It allows the chemist to monitor the progress of the digestion whilst being fully protected by the instrument's all-stainless steel door. A video of the entire run is shown in real time.

Sensors for unparalleled digestion control

In a digestion process, the temperature controls the sample decomposition and directly affects digestion quality. Milestone pioneered the use of infrared sensors combined with an in-situ temperature sensor. Today, Milestone innovates again by combining all the benefits of in-situ and infrared sensors into the Milestone easyTEMP, a direct contactless temperature sensor.

Temperature control with easyTEMP

The easyTEMP contactless sensor directly controls the temperature of all samples and solutions, providing accurate temperature feedback to ensure complete digestion in all vessels with superior safety. This technology combines the fast and accurate reading of an in-situ temperature sensor with the flexibility of an infrared sensor.
The ETHOS UP software provides digestion history traceability and temperature measurement for every sample. Temperature diagrams and profiles are displayed in real-time, and can be saved on the ETHOS UP terminal.
In combination with our 'vent-and-reseal' vessel technology, these sensors ensure complete and safe digestions without any loss of volatile compounds.

Smart software to save your time!

The Ethos Up comes with a touch screen terminal with easyCONTROL software which provides full control of all digestion parameters, complete documentation and improves the overall procedure. Hundreds of applications including all US EPA methods, are preloaded in the Ethos Up terminal virtually eliminating any need for method development. To further simplify the workflow in the lab the Ethos Up is equipped with a backlit logo that indicate the actual status of the digestion process.

  • ● Hundreds of methods factory installed

  • ● Visual indication of temperature and pressure values

  • ● Methods and runs printed or stored as PDF files

  • ● Instrument´s trail tracking (CFR-21 part 11 compliance)

  • ● Easy-to-read, bright, full-color, touchscreen display

  • ● Icon-driven, multi-language software

Rotors

The game changer in microwave digestion

ultraWAVE


The Game Changer in Microwave Digestion

The ultraWAVE fully endorses our vision in microwave sample preparation: it has already revolutionized and enhanced the way analytical chemists think to sample preparation for trace metal analysis in hundreds of laboratories all over the world.

Video Presentation

Brochure

SRC Technology

The ultraWAVE is based on the SRC (Single Reaction Chamber technology), invented by Milestone several years ago (Patents pending). SRC technology achieves extraordinary performance capabilities combining microwave heating with a high-pressure reactor which acts simultaneously as microwave cavity and vessel. The ultraWAVE chamber is sealed, pressurized, heated, cooled, vented, and opened via a dedicated touch-screen control terminal. Loading a rack of samples into the chamber is the only manual operation in an otherwise fully automated process of microwave-assisted sample preparation. The outer surfaces of the vessel remain at room temperature throughout the entire microwave heating cycle. As a result, the ultraWAVE is dramatically less labor intensive and easier to use compared to conventional microwave digestion systems.

  • High performance: The highest temperatures & pressure capabilities and the fastest cooling time

  • Increased throughput: Double throughput of traditional microwave acid digestion instruments.

  • No batching required: Simultaneous digestion of any sample type combination.

  • Ease of use: Cleaning of digestion vials is not necessary. No vessel assembly/disassembly.

  • Expertise and Support: 30-years experience at your lab with the Milestone Connect.

  • ● Compliance: USP 232/233 Chapters, ICH Q3D Guidelines and FDA regulation 21 CFR part 11.

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Easy-to-use technology

For optimized workflow

Operating Sequence

1. Loading

At the core of the ultraWAVE is a TFM-lined reaction vessel. Samples are weighed into vials, and suitable reagents are added. Rack with vials is automatically lowered into the reaction chamber.

2. Closing and pressurizing

The chamber is sealed and pressurized with inert gas, which physically acts as a cap for the vials, avoiding boiling of the solutions and preventing cross contamination.

2. Heating and cooling

Microwave energy is applied, with all samples at the same temperature and pressure conditions. At the end of the microwave run, a cooling device rapidly lowers the temperature of the solutions.

4. Pressure release and opening

The entire rack is automatically lifted up to facilitate the removal of the solution vials. As a visual aid for the user, the color of the backlit logo indicates the process status.

Digestion vials

 The ultraWAVE rack configurations include 4, 5, 8, 15, 19, 22 and 26 position and combinations thereof. Vials are available in TFM, quartz or disposable glass, and are fitted with loose TFM caps to ensure pressure equalization. Unlike conventional microwave digestion systems, no vessel assembly or disassembly is required. The use of disposable glass vials eliminates the cleaning step, further enhancing the lab’s workflow. The fast assembly of the vials, the automatic closing and opening cut the handling time, reducing the labour cost up to 50%.

Safety

Like all Milestone products, the ultraWAVE has been designed with operator safety of paramount importance: it has been developed for being used with any acid or combination thereof, and every single reactor is tested at a pressure up to 330 bar. A thick acrylic shield surrounds the working area, and runs cannot be started unless the chamber clamps are in correct position. Temperature and pressure are monitored 20 times/sec, automatically adjusting microwave power to control even highly exothermic reactions.

Find the suitable rack for your lab

Any sample, any time

The benefits of SRC technology

One method for all samples

Any combination of sample types (food, environmental, polymer, cosmetic, pharmaceutical, geological, chemical, and petrochemical) can be digested simultaneously; no need to batch samples into identical types. No method development is needed, as the same method can be used for nearly any sample. And for the first time, blanks and reference standards of any matrix can be digested alongside samples, enabling true in-run digestion quality control.

R=Standard Reference. B=Analytical Blank.
The UltraWAVE is capable of processing in a single run different unknown samples along with certified reference materials and analytical blanks.

Superior digestion quality

Operating up to 199 bar pressure and 300°C temperature, the ultraWAVE enables the complete digestion of extremely difficult samples and of large amounts of organics, outperforming any other microwave digestion system. Unlike conventional microwave digestion systems, every sample is under direct temperature and pressure control, so there is no need to rely on a reference vessel or to an indirect control such as infrared temperature sensors.
The ultraWAVE reaches high temperatures faster, cools faster (10 minutes from 200°C to room temperature), and is capable of higher pressure and temperature than any other system. The ultraWAVE does not suffer of any cross contamination among samples. Blanks are significantly lower than with conventional microwaves, since less acid is used and vials have a much less surface in contact with the analytical solution.

Efficient and Cost-Effective

High Productivity

Typical sample turnaround time (number of samples in 8 hours).

Compared to any other conventional microwave digestion systems, the ultraWAVE is significantly easier to use, thus dramatically improving the laboratory work flow. Up to 26 samples are processed in 45 minutes start to finish. Ease to say that the ultraWAVE sample throughput is far better than any other microwave systems.
All samples are processed in a single run at the same temperature and pressure, eliminating the need to run multiple digestion cycles for different samples or matrices. The use of disposable glass vials eliminates the cleaning step, further enhancing the ultraWAVE productivity.

Low Operation Cost

The ultraWAVE accommodates inexpensive disposable vials.

Opening and closing the vessels, assembly and disassembly of the rotors are not required in the ultraWAVE anymore. The handling of the system is dramatically reduced, and tedious and time-consuming procedures are eliminated.
The technology used in all conventional microwave lead to create stressful conditions in the TFM vessels, substantially reducing their lifetime. The design of SRC technology in the ultraWAVE strongly contributes to the reduction of the running costs by using inexpensive and handy vials suitable for any metals and trace metals determination.

Smart sofware designed around you

The ultraWAVE is controlled via a compact external terminal with an easy-to-read, bright, full-color, touchscreen display. Multiple USB and Ethernet ports are provided, for interfacing the instrument to external devices and to the local laboratory network. The terminal runs the Milestone easyWAVE, a completely new user-friendly, icon-driven, and multi-language software. Just recall a previously stored method or create a new one; press the Start icon and the system will automatically follow the user defined temperature profile using a sophisticated PID algorithm.
Hundreds of applications, including all US EPA methods, are preloaded, eliminating any need for method development.


Need to fulfill regulatory requirements?

The Milestone Validation Packages include several protocols in order to fulfill regulatory requirements, such as the Good Manufacturing Practice (GMP) guidelines that, along with our superior support and expertise, will be by your side throughout the whole process. Our experts will support you with the right confi guration, with a dedicated procedure for your samples, with a demonstration of the system’s capabilities and with a complete validation package that includes: DQ (Design Qualification), IQ (Installation Qualification), OQ (Operational Qualification), PQ (Performance Qualification) and the requalification. All the tests carried out by our service engineers are guaranteed by certified test equipment, providing high accuracy and meeting all the regulatory requirements. Our software is fully compliant with the FDA regulation 21 CFR part 11, with an exhaustive audit trail for complete traceability. The MVP is one of the multiple services offered by Milestone to ensure the highest industry standards in customer support.

Fully automated single reaction chamber microwave digestion system

ultraCLAVE


Fully automated single reaction chamber
microwave digestion system

The patented Milestone ultraCLAVE achieves extraordinary performance capabilities by combining SRC patented technology with the highest throughput available in the market.

Brochure

The technology that revolutionized sample preparation

The ultraCLAVE's utilization of SRC technology allows for the processing of mixed matrices in the same run with different chemistries and to use vials/racks instead of vessels/rotors, which essentially removes the handling step in sample preparation. The ultraCLAVE completely changes the rules in microwave sample preparation and sets new standards in digestion, enhancing the overall efficiency in elemental analysis. The ultraCLAVE is capable of running as many as 77 samples simultaneously at high temperature up to 300 °C and pressure up to 200 bar, thus enhancing lab efficiency.

  • Market-leading innovation

  •  Fully automated

  • Enhanced performance

  • Unsurprised throughput

  • Great return on investment

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

A step forward in sample preparation automation

The patented Milestone ultraCLAVE achieves extraordinary performance capabilities by combining direct microwave heating in a high pressure reactor, which acts simultaneously as microwave cavity and vessel. Microwave energy is introduced into the reactor through a unique microwave port. This focused-multimode cavity design ensures maximum sample heating efficiency. Heat generated in the reactor is removed by a re-circulating cooling system, and the stainless steel vessel remains at approximately room temperature throughout the entire heating cycle.
The ultraCLAVE is designed for simplicity of use. Loading a rack of samples into the chamber is the only manual operation required. The reaction chamber is sealed, pressurized, heated, cooled, vented, and opened all under computer control.
The system dramatically reduces the labor compared to conventional microwave systems.


The operating sequence with SRC technology

Sample preparation is the most labor-intensive step in elemental analysis, as it requires assembling, closing, opening and disassembling of the vessels. These operations involve a lot of handling, which is directly affected by the number of vessels used. The ultraCLAVE with SRC technology, uses vials and racks instead of rotors and vessels, completely removing laborious handling. SRC technology is based on a stainless-steel reactor with a volume in excess of 4 L, which act as both a microwave cavity and digestion vessel. A 3.5 L PTFE vessel with a base load is introduced into the stainless-steel reactor. The operator places the samples and acids into vials with loose-fitting caps, places the rack in the ultraCLAVE and the digestion process begins (Step 1). By pressing “START” on the dedicated large screen terminal, the system automatically closes the stainless-steel vessel and clamps, loads the nitrogen pressure and runs the pre-selected microwave program (Step 2). After completion the vials are cooled using a powerful external chiller, pressure is safely released, and the main reactor opens, delivering the digested solutions ready for dilution and analysis (Step 3).

1. Rack loading

 

2. MW heating

3. Opening

Gain efficiency without compromising performance

Performance

The combination of stainless-steel reactor with microwave technology results in a digestion system with superb performance and abilities. The temperature range up to 300 °C allows for the digestion of virtually any sample, while the maximum pressure of up to 200 bar allows for digesting very large sample amounts. Highly reactive samples such as large amounts of food, pharmaceuticals, polymers and petrochemicals can be completely digested. Furthermore, the platform's flexibility found a natural fit in other analytical testing labs such as environmental, clinical and biological. The ultraCLAVE allows for the simultaneous digestion of completely different matrices with different chemistries, as the set conditions in the stainless-steel cavity are applied to all vials, ensuring complete digestion of all samples in the reaction chamber.

Typical ultraCLAVE digestion cycle with the 40 position rack. 0.5 g of organic samples such as infant formula, butter an API and fish oil with 5 mL of HNO3

Greater productivity & ROI

SRC technology offers high throughput without compromising productivity. The ultraCLAVE greatly reduces handling and operator time, eliminates the need to batch the samples and to clean of vials, resulting in a more productive approach to digestion across multiple industries. Most samples will be digested using a single program, eliminating method development and simplifying the digestion procedure. The ultraCLAVE is an efficient tool for mixed or similar samples. Lab throughput is greatly enhanced, with a digestion cycle taking about 60 minutes for 40 or 77 samples. Lab efficiency is improved by removing the need to batch samples, speeding up the digestion cycle and using inexpensive consumables. The ultraCLAVE offers superior productivity, ease of use and performance far surpassing any conventional digestion system.

The above graph compares the efficiency ratio between a rotor-based system (f.e. 40 positions) and the ultraCLAVE (with 40 positions) with SRC technology, considering operator time, productivity and running costs

ultraCLAVE rack loaded with different matrices

Digestion vials

Racks and vials with loose-fitting caps greatly simplify daily operation and reduces running costs. The ultraCLAVE racks are available in several configurations, from 6 to 77 individual samples, to accommodate varying sample throughput needs as well as large sample masses. The selection of vials includes high-purity PTFE, quartz and disposable glass. The use of disposable glass vials eliminates the tedious and time-consuming cleaning step, improving lab workflow. Rack handling is as simple as hanging it in the system. Moreover, SRC technology allows for the use of a single method regardless of the sample type and amount, making it possible to digest different matrices together in the same run.

We Serve Pharmaceutical Labs

Discover our commitment new USP <232>/<233> and ICH Q3D
for Ensuring Safer Drugs for Providing High Quality API’s

Determining Elemental Impurities in Pharmaceutical Products

New methods and guidelines from United States Pharmacopeia (USP) Chapters USP <232>, <233> and <2232> as well as guidelines from International Conference on Harmonization (ICH observed by the European Medicines Agency (referred as ICH Q3D) set new standards in laboratory analysis and sample preparation for pharmaceutical samples. Determination of elemental impurities in pharmaceutical products can be made from the sources like catalysts, raw materials, production processes, and packaging materials.
The implementation of the new USP chapters <232> and <233> on elemental impurities in January 2018 redefined analysis and sample preparation in pharmaceutical industry.
Milestone offers chemists a practical guidance for determining elemental impurities in pharmaceutical products and dietary supplements.

Flexibility and performance that make the difference

Digestion Rotor Technology


Flexibility and performance that make the difference

The SK-15, MAXI-44 and MAXI-24 HP digestion rotors feature unique Milestone MDR technology to control the inner pressure of all vessels in complete safety. This 'vent and reseal' technology for pressure release is the foundation of Milestone's leadership in microwave digestion.

Brochure

System description

The SK-15, MAXI-44 and MAXI-24 HP offers, high quality digestion, high sample throughput and high performance. A large selection of high purity quartz and TFM inserts are available for these rotors to work with smaller sample amounts or to minimize the dilution factor of analytical solution.
Our microwave digestion systems can be used with a wide range of rotors and accessories providing a flexible, versatile and productive platform for digestion and extraction processes, microwave synthesis, protein hydrolysis and vacuum evaporation. For example, our selection of extraction rotor with flagship fastEX-24 with disposable vessels can extract up to 30 grams of sample with minimum solvent volume.

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

SK-15 - easyTEMP

HIGH-PRESSURE ROTOR

Regardless of the samples you’re trying to digest, the SK-15 High-pressure rotor is always an effective option to simplify your journey from sample to analysis, even with hard-to-digest samples, reactive samples or large sample masses. The SK-15 is a high-pressure and high-temperature rotor with a capacity of up to 15 PTFE-TFM vessels of 100 mL.

See SK-15 Rotor in Action

  • ● Unmatchable versatility

  • ● Large Sample Match

  • ● High Performance

MAXI-44 - easyTEMP

HIGH-TROUGHPUT ROTOR

Many laboratories routinely process high number of samples, such as soils, sediments and aqueous samples. The MAXI-44, featuring up to 44 PTFE-TFM vessels of 100 ml, perfectly matches these requirements, providing high productivity, reliability and superior ease of use. The MAXI-44 finds its natural fit in all laboratories requiring to process large samples batches.

See Maxi-44 Rotor in Action

  • ● Digest Large Batches

  • ● Easy Handling

  • ● High Productivity

MAXI-24 HP - easyTEMP

HIGH-PERFORMANCE TROUGHPUT ROTOR

The MAXI-24 High Performance (HP) and high throughput rotor was designed with double pressure limits and greater capacity than other high throughput rotors. It process increased volumes of sample and a wide variety of matrices within a single rotor-based platform. Quick-assembly vessels are closed with a simple hand-tightening, improving your daily productivity.

See Maxi-24 HP Rotor in Action

  • ● Greater Digestion Capacity

  • ● High Throughput for Several Applications

  • ● More Profitable Runs

Flexibility

With the comprehensive choice of rotors and accessories available, you can turn the ETHOS UP and ETHOS EASY into a versatile platform able to perform also solvent extraction, protein hydrolysis, vacuum evaporation and alkaline fusion.

fastEX-24

The fastEX-24 rotor extracts up to 30 grams of sample with minimal solvent volume. It uses disposable glass vials, eliminating the need for cleaning and the possibility of memory effect between different runs. The 100 mL vials can accommodate the extraction of a large sample amount.

SK-12

The high strength SK rotor body holds up to 12 digestion vessels made of high purity TFM. This rotor ensures complete digestion of any sample, including relatively difficult organic and inorganic refractory materials.

MAXI-14

14-position rotor with 100 ml TFM medium pressure vessels. Vent-and-reseal technology. Contact-less temperature control in all vessels.

MMR-15

The MMR-15 can be used for vacuum assisted sample drying prior digestion, and solution concentration at the end of the decomposition process. The MMR-15 accommodates up to 15 TFM vessels of 100 mL. They are the same vessels used in the SK-15 digestion rotor, so no transfer of the solution is required when performing drying and concentration. Microwave modular rotor that takes advantage of the US patent 5,447,077.

SK-10

The high strength SK rotor body holds up to 10 digestion vessels made of high purity TFM. This rotor ensures complete digestion of any sample, including relatively difficult organic and inorganic refractory materials.

Ultrafast

High-temperature muffle furnace suitable for fusions, up to 1200°C. A variety of difficult samples, such as cements, ores, slag, sediments, soils, rocks, ceramics, pigments, and glasses, can be successfully prepared for XRF, AA and ICP analysis.

Utratrace inserts

This configuration reduces the amount of acid required for digestion to near stoichiometric quantities, which reduces the dilution factor and improve the detection limit.

  • ● Less acid volume

  • ● Higher sample amount

  • ● Lower dilution factor

  • ● Increased method detection limit

  • ● Less surface contamination

  • ● Lower analytical blank

Vessel Venting Technology

Patented "Vent-and-Reseal" Technology

All Milestone rotors feature an enhanced 'vent-and-reseal' technology for controlling the inner pressure of all vessels with complete safety. This patented (US Patent 5,270,010) technology provides the operator with unsurpassed safety and performance capabilities: highest temperature and pressure, highest safety standards, ease of use, and very fast cooling (180°C to 40°C in 10 minutes). While other systems use membranes or burst disks that render a vessel useless after venting, the Milestone system releases only the excess pressure from the vessel. This ensures that there is no stress to the door of the microwave system and no loss of sample as could happen in the

 case of a membrane or disk bursting. The illustration shows 'vent-and-reseal' in action: the vessel cap is held in place by a dome-shaped spring (1). In the case of over pressure due to a highly exothermic reaction, the spring is flattened, allowing the cap to lift up slightly (2) releasing excess pressure. Immediately the excess pressure is released, the spring reseals the vessel (3), and the digestion continues. There is no loss of sample and no clean up needed. The microwave program continues to completion and no re-run is required. While there are other methods of venting, only Milestone has 'vent-and-reseal' technology.

  • ● Superior performance

  • ● Higher safety and reliability

  • ● Low running costs

Self-regulated venting

The final method of venting is "self-regulating" and is used in the MAXI-44 rotor, and high-throughput rotors supplied by other manufacturers. These extreme throughput rotors were developed to address the needs of labs that process larger sample volumes on a routine basis. Self-regulating vessels are very easy to assemble/disassemble and rely on the Teflon

sealing plug inside the cap deforming to release pressure. Their compact design results in more moderate temperature and pressure capabilities, but allows for a large number of vessels to fit onto the rotor. These characteristics make self-regulating rotors ideal for easy to moderate applications such as clinical, environmental, food, etc. Most recently, some manufacturers have

applied the self-regulating approach to high pressure rotors designed specifically for more challenging sample types. Since self-regulating vessels are designed to vent, incomplete or unsatisfactory digestions may be observed given that the pressure loss does not allow the mandatory temperatures necessary for complete digestion to be achieved.

Other method of venting

There is another approach to venting, but it implies limitations compared to Milestone's Vent-and-Reseal and Self-regulating technology.

Burst disk

This method employs a simple burst disk in the cap which is designed to fail in an over pressure situation, instantly releasing all pressure in the vessel. When this happens, instantaneous boiling occurs, the sample contents are lost and the run has to be manually stopped. Significant clean up of the cavity is required, and corrosion of the cavity and internal components will occur. The

illustration compares the burst disk approach with 'vent-and-reseal': the red line shows the complete loss of pressure when a burst disk fails, and the whole run is stopped. The blue line shows what happens with Milestone's 'vent-and-reseal' technology: excess pressure is gently released at just over 30 bar, and the digestion continues to completion, with no loss of sample.

Quartz sub-boiling distillation system

subPUR and duoPUR


Quartz sub-boiling distillation system

Milestone has developed the duoPUR and subPUR, sub-boiling distillation systems which allow laboratories to make their own high purity acids at dramatically reduced costs.

Make your own ultrapure acids

The chemical reagents used during the analysis are an important source of the analytical blank. Sub-boiling distillation has been demonstrated to be the best method of acid purification. Offering an optimal purification method for preparation of high purity reagents, this type of acid distillation uses contactless infrared lamps to vaporize the surface liquid at a temperature typically 20°C below the boiling point.
In contrast to conventional distillation systems, where strong boiling action generating aerosolized particles results in contamination of the original liquid with the distillate, the duoPUR acid purification system using sub-boiling technology provides gentle surface evaporation preventing the formation of spray or droplets and yields to ultrapure acids.
The duoPUR offers an alternative to the purchase of expensive high purity acids for trace elemental analyses.

  • Up to 90% cost saving of ultrapure acids

  • High productivity, up to 400 mL per hour with duoPUR

  • ‘On-demand’ acid purification

  • Re-purification of contaminated acids

  • Single or double distillation upon on requirements

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

“In the preparation of high purity reagents,
there is only one significant and practical choice
for the method of purification: sub-boiling distillation"
US EPA SW-846, Chapter 3, Update IVB.

Why sub-boiling technology?

 

The chemical reagents used during the analysis are an important source of the analytical blank. Sub-boiling distillation has been demonstrated to be the best method of acid purification. It uses contactless infrared lamps to vaporize the surface liquid at a temperature typically 20°C below the boiling point. In contrast to conventional distillation, where strong boiling action generating aerosolized particles results in contamination of the original liquid with the distillate, a gentle surface evaporation during sub-boiling distillation prevents the formation of spray or droplets and yields to a very high pure acid.

duoPUR Quartz sub-boiling system

The duoPUR consists of two quartz distillation units. Each unit contains two infrared heating elements (1), a water cooled condenser (2), a high-purity PFA collection bottle (3), and a fully automatic acid loading/discharge system. The vaporized liquid is collected on the inclined water-cooled condenser and drips into the collection bottle. The distillation process is microprocessor controlled, allowing the user to set the distillation time and power level by using a compact control terminal with easy-to-read, bright, full-color, touch-screen display. The distillation rate ranges from 50 to 400 mL per hour, depending on the power setting and the temperature of the cooling water.

Compare Sub-boiling and traditional distilaltion

Do you know how to reduce the sample prep blank?

Read our book! It explains how a laboratory can reach full control of analytical blanks and sample preparation for obtaining accurate results. The application of instruments and strategies to control sample prep blank is often called a “Clean Chemistry” technique. This book discusses the factors impacting blank quality, in particular when microwave digestion is used, and reviews some Clean Chemistry products and technologies designed to help the analyst generate superior analytical data on their ICP-OES or ICP-MS instrumentation.

This email address is being protected from spambots. You need JavaScript enabled to view it.

How Much Will Sub-Boiling Distillation Save You Each Month?

Calculate ROI with our Worksheet

PTFE sub-boiling distillation system

subCLEAN


PTFE sub-boiling distillation system

The Milestone subCLEAN is a compact and easy-to-use sub-boiling system suitable for the purification of HF, as well as for HNO3 and HCl.

Brochure

Make your own HF, HNO3 and HCl acids

The chemical reagents used during the analysis are an important source of the analytical blank. Sub-boiling distillation systems has been demonstrated to be the the leading method of acid purification.
In contrast to acid purification through conventional distillation, where strong boiling action generating aerosolized particles results in contamination of the original liquid with the distillate, acid distillation system using sub-boiling technology prevents the formation of spray or droplets and yields to a very high pure acid.
The Milestone subCLEAN is a compact and easy-to-use sub-boiling system, where all parts in contact with acids are made of high-purity fluoropolymers. Offering an optimal purification method for preparation of high purity reagents, our subCLEAN system is therefore suitable for HF, as well as for HNO3 and hydrochloric acid purification.

  • ● Up to 90% cost saving of ultrapure acids

  • ● High productivity

  • ● ‘On-demand’ acid purification

  • ● Re-purification of contaminated acids

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

“In the preparation of high purity reagents, there is only one significant and practical choice for the method of purification: sub-boiling distillation"
US EPA SW-846, Chapter 3, Update IVB.

Why sub-boiling technology?

With subCLEAN system, the acid is automatically loaded into the distillation container, where it is gently heated below its boiling temperature. All process is microprocessor controlled by using a compact control terminal with easy-to-read, bright, full-color, touch-screen display.
The subCLEAN does not require cooling water or a chiller, as acid vapors rapidly condense into a collection bottle

Compare Sub-boiling and traditional distillation

Compare acid steam cleaning to acid leaching

The container to be cleaned is placed over a PTFE coated glass rod. Acid in the lower reservoir is heated, and purified acid vapor travels up through the glass rod and condenses on the container, removing surface contamination. This method of cleaning is a preferred alternative to the soaking preconditioning methods for the following reasons:


1, The trace metal contamination found in the reagent grade acid remains in the lower reservoir and does not come in contact with the component to be cleaned.
2. The clean component does not remain in contact with the cleaning acid after the surface contamination is removed.
3. The critical surfaces of the clean component are dry when the cleaning process is complete. This eliminates the need for rinsing and air drying.
4. The cleaning process takes place in a sealed container which minimizes airborne contamination and provides a clean environment for the components to be stored until they are needed.

Compare techniques

How Much Will Sub-Boiling Distillation Save You Each Month? by forced air cooling.

Calculate ROI with our worksheet

Do you know how to reduce the sample prep blank?

Read our book! It explains how a laboratory can reach full control of analytical blanks and sample preparation for obtaining accurate results. The application of instruments and strategies to control sample prep blank is often called a “Clean Chemistry” technique. This book discusses the factors impacting blank quality, in particular when microwave digestion is used, and reviews some Clean Chemistry products and technologies designed to help the analyst generate superior analytical data on their ICP-OES or ICP-MS instrumentation.

This email address is being protected from spambots. You need JavaScript enabled to view it.

Acid steam cleaning system

traceCLEAN


Acid steam cleaning system

traceCLEAN assures best cleaning quality of your TFM, glass and quartz parts for ICP/ICP-MS accessories. Any trace metal contaminants that are present in the cleaning acid stay within the reservoir and do not come in contact with the cleaned trace accessories.

Brochure

Full contamination control from containers

Cleaning various items used in ultra-trace analysis work is a critically important laboratory routine. To minimize contamination, traditional cleaning methods require soaking items in hot acids, often for several hours. To be effective large volumes of acid are consumed and need to be changes regularly. There is also a substantial risk of exposure to hot acids and acid vapors using traditional soaking techniques. To address these issues, Milestone has developed the traceCLEAN, a fully automated, self-contained, acid steam cleaning system for trace metal analysis accessories.

  • Versatile

    Best cleaning quality of lab apparatus, either TFM, glass and quartz parts

  • Safe and Easy-to-use

    No operator exposure to acid vapors.

  • Highly Productive

    Fast, convenient, clean, and fully automated.

  • Cost-effective and productive

    No changing of acids or soaking required.

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

“In trace analysis the effects of contamination from laboratory air or furnishings, apparatus, containers, and reagents have become increasingly important, as the sensitivity of analytical methods has lowered detectable limits to the nanogram and picogram level”.
M. Zief, J. W. Mitchell, Contamination Control in Analytical Chemistry

How it works

Steam cleaning with nitric or hydrochloric acid vapors is a very effective cleaning method for preconditioning and routine cleaning of containers and apparatus. The container to be cleaned is placed over a PTFE coated glass rod. Acid in the lower reservoir is heated, and purified acid vapor travels up through the glass rod and condenses on the container, removing surface contamination.

Compare acid steam cleaning to acid leaching

The container to be cleaned is placed over a PTFE coated glass rod. Acid in the lower reservoir is heated, and purified acid vapor travels up through the glass rod and condenses on the container, removing surface contamination. This method of cleaning is a preferred alternative to the soaking preconditioning methods for the following reasons:


1, The trace metal contamination found in the reagent grade acid remains in the lower reservoir and does not come in contact with the component to be cleaned.
2. The clean component does not remain in contact with the cleaning acid after the surface contamination is removed.
3. The critical surfaces of the clean component are dry when the cleaning process is complete. This eliminates the need for rinsing and air drying.
4. The cleaning process takes place in a sealed container which minimizes airborne contamination and provides a clean environment for the components to be stored until they are needed.

Compare techniques

Do you know how to reduce the sample prep blank?

Read our book! It explains how a laboratory can reach full control of analytical blanks and sample preparation for obtaining accurate results. The application of instruments and strategies to control sample prep blank is often called a “Clean Chemistry” technique. This book discusses the factors impacting blank quality, in particular when microwave digestion is used, and reviews some Clean Chemistry products and technologies designed to help the analyst generate superior analytical data on their ICP-OES or ICP-MS instrumentation.

This email address is being protected from spambots. You need JavaScript enabled to view it.

Ultratrace Inserts for low blank levels

Vessel-Inside-Vessel Technology


Ultratrace Inserts for low blank levels

Setting new standards in vessel inside vessel technology  
We introduce the best of vessel-inside-vessel solutions to ensure lower analytical blank during microwave digestion in modern laboratory. This configuration reduces the amount of acid required for digestion to near stoichiometric quantities which provides lower dilution factor to increase detection limit

Brochure

Increase detection limit with lower dilution factor

Microwave digestion techniques typically require a minimum volume of reagents of about 5 mL to achieve accurate temperature monitoring of the reaction conditions and for low blank levels. However sometimes it is important to maintain an even lower dilution factor when working at concentrations near the method detection limit. These factors inspired us to use vessel-inside-vessel technology. It uses smaller secondary vessel (2) inside the primary microwave vessel (1). The secondary vessel contains sample and digestion reagents (3), while the primary vessel contains the solution in which temperature control takes place.
This setup reduces the amount of acid required for digestion, lowering dilution factor and increasing detection limit.
A variety of vessel inserts is available from Milestone in different materials (Quartz or TFM) provided in different sizes and shapes, to satisfy all application requirements.

  • ● Less acid volume

  • ● Higher sample amount

  • ● Lower dilution factor

  • ● Increased method detection limit

  • ● Less surface contamination

  • ● Lower analytical blank

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

“To keep blank levels as low as possible the analyst must exercise care in keeping the volume of reagents to a minimum”.
T. Murphy, The role of analytical blank in accurate trace analysis.

Why maintaining a very low dilution factor

Analytical chemists are being required to measure lower and lower levels of trace metals in samples. This frequently requires the analyst to make measurements near the method detection limit which usually result in decreased accuracy and precision. Closed-vessel microwave digestion techniques require a minimum volume of 10 mL to achieve accurate temperature monitoring of the reaction conditions. Ideally, modern spectroscopic techniques require samples submitted for analysis to have acid concentration of 1 to 5% v/v. This requires samples that were digested with 10 mL of acid to be diluted by a factor of 500 to achieve the 1 to 2% acid content necessary for ICP analysis. These large dilution factors often result in some of the analytes becoming non-detectable.
These large dilutions are often overcome by maximizing the sample size relative to the amount of digestion acid. This approach works well for samples that do not contain a large amount of organic material. For samples with high organic content this is usually not an option because the reaction gases (CO2 and NOx) produced during the digestion can cause the microwave vessel to vent when larger sample sizes (greater than 0.5 grams) are used. Recent advances in understanding of microwave-assisted sample preparation have led to the development of vessel inside vessel technology as a means to improving method detection limits for high organic samples.
The Vessel inside vessel technology provides better reaction control. Controlling reaction kinetics is especially important when trying to digest large quantities (0.5 to 1.0 g) of organic material because the potential for auto-catalytic decomposition increases. Moreover, it helps control these self-sustaining auto-catalytic reactions by providing a heat sink for the energy liberated during oxidization.

No cross contamintion

Three blanks were analyzed in run #1. The same blank was prepared along with two Animal Tissue samples, showing no cross contamination.

Blank 2 mL HNO3. Analysis by ICP-AES

Sample weight 100 mg. Blank 2 mL HNO3. Analysis by ICP-AES


Complete Recovery

Polyethylene EC680K Sample weight 200 mg. Blank 2 mL HNO3. Analysis by ICP-AES

Human Hair IAEA 085 Sample weight 100 mg. Blank 2 mL HNO3. Analysis by ICP-AES

Do you know how to reduce the sample prep blank?

Read our book! It explains how a laboratory can reach full control of analytical blanks and sample preparation for obtaining accurate results. The application of instruments and strategies to control sample prep blank is often called a “Clean Chemistry” technique. This book discusses the factors impacting blank quality, in particular when microwave digestion is used, and reviews some Clean Chemistry products and technologies designed to help the analyst generate superior analytical data on their ICP-OES or ICP-MS instrumentation.

This email address is being protected from spambots. You need JavaScript enabled to view it.

Fast ashing in minutes instead of hours!

PYRO High Thoughput


Advanced Microwave Muffle Furnace

The new Milestone PYRO is an advanced microwave ashing furnace perfectly suitable for sulphate ashing, loss on ignition (LOI), residue on ignition (ROI), fusion and all types of high-temperature reactions under controlled conditions.

Brochure

Fast ashing in minutes instead of hours!

Determination of ash content is an important test performed daily in thousands of laboratories worldwide whether for process control or for preparation of other analytical processes.
While ashing is a relatively simple process, conventional muffle furnaces are often inefficient, leading to tedious and time-consuming procedures. The invention of microwave furnace for dry ashing applications has represented a breakthrough in the process and quality control of samples like polymers, petroleum, food and feeds, pulp paper and pharmaceuticals. Unique design of PYRO microwave muffle furnace ashing system eliminates equipment corrosion and acid fume pollution, greatly reducing analyst exposure to acid fumes. PYRO ashing furnace ensures usage of all available crucibles including metal, porcelain and quartz fiber. In particular, the unique Milestone UltraFAST quartz fiber crucibles are perfectly suitable for microwave diffuser and further acceleration of suphate ashing process.

  • Enhanced performance. Advanced microwave heating in just 8 minutes instead of hours!

  • ● Three interchangeable configurations. Choose your preferred set-up and crucible types

  • Operator's safety. No exposure to heat and fumes

  • Standard method compliance. ASTM, USP, SEMI and ISO compliance

  • Rugged and durable construction. Standard 1 year warranty!

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Rugged and durable construction
STANDARD 1 YEAR WARRANTY!

While ashing is a relatively simple process, conventional muffle furnaces are often inefficient, leading to tedious and time-consuming procedures. The advent of microwave technology for dry ashing applications has represented a breakthrough in the process and quality control of samples like polymers, petroleum, food and feeds, pulp paper and pharmaceuticals.

LARGEST MICROWAVE CAVITY

Equipped with a full stainless steel door, the new Milestone PYRO microwave cavity has a volume in excess of 70 liters, thus allowing the use of a large muffle which in turn enhances the sample throughput. Additionally, a large cavity ensures that the outer temperature of the PYRO remains very low, even when the inner temperature of the furnace is in excess of 1.000°C.

TEMPERATURE CONTROL

The new Milestone PYRO is equipped with the most advanced yet easy to use temperature sensors for complete control of the ashing conditions. These NIST-traceable sensors allow rapid verification and calibration of the furnace temperature for ISO and GLP procedures.

HIGHEST POWER

The PYRO is equipped with two 950 Watt magnetrons for a total of 1900 Watt making it the most powerful microwave muffle furnace system available in the market. The system additionally employs a rotating diffuser that evenly distributes the microwaves throughout the cavity, assuring a uniform temperature is achieved inside the furnace

METHOD COMPLIANCE

The PYRO meets or exceeds the equipment requirements for electrically heated furnaces in the following methods: ASTM, USP ROI 281 and LOI 733, AOAC, FDA, ISO and DIN. It also meets or exceeds the requirements for applications listing a microwave heated furnace in the following methods: ASTM D5630-94 and ASTM D1506-94b.

A dedicated configuration for every need

The PYRO is available in 3 different and interchangeable configurations: ultrafast heating setup, high sample throughput setup and sulfated ashing setup; it is therefore the most flexible and adaptable microwave muffle furnace available in the market.

High Sample Throughput

The PYRO with High-Throughput Setup accommodates up to 24 Milestone quartz fiber crucibles. A unique, rugged, solid, microwave–transparent, ceramic muffle allows microwave radiation to pass through and rapidly raise the temperature of a silicon carbide plate. Sample crucibles are placed on a large clean quartz plate and an airflow is induced by a built-in exhaust system. A porous ceramic honeycomb frit built into the wall of the muffle furnace allows a constant stream of air to pass over the sample crucibles. The combination of microwave “superheating” and induced airflow results in a dramatic reduction of the ashing time. Furthermore, a large quartz tube located above the muffle conveys gases and vapors generated by the ashing process to the exhaust pipe.
A very accurate and precise thermocouple monitors and controls the temperature inside the furnace. The sensor signal serves as a feedback control mechanism to regulate microwave power output and to maintain the desired temperature profile.
Any type of crucible (metal, porcelain, quartz, etc.) can be used.

UltraFAST Heating

As the name implies, the PYRO with UltraFAST Setup has an extremely fast heating rate. A typical ashing temperature of 800°C can be reached in just 5 minutes, starting from room temperature! This eliminates the need of running the system overnight, and avoids the lengthy heat up time associated with electrical resistance furnaces, dramatically lowering the power consumption and cost.
A circular heating element assures a perfect temperature uniformity throughout the cavity, largely exceeding requirements of ASTM, USP, SEMI and ISO standard methods. Temperature is monitored and controlled via a contact-less infrared sensor. Up to 5 crucibles are located on a ceramic tray, which can be easily removed from the muffle at the completion of the microwave run.
The incredibly fast heating rate of this PYRO setup, combined with the properties of the Milestone UltraFAST crucibles, makes this configuration the best choice for all high-temperature applications requiring no heating/cooling inertia.

Sulphated Ashing

Ashing of pharmaceutical, polymers, and food samples often involves the use of sulfuric acid. Hot sulfuric acid vapors are hazardous to analysts and corrosive to equipment. Additionally, sulfate ashing methods are labor-intensive and time-consuming, requiring manual fuming of the acid and 8-12 hours to be completed. To overcome these issues, Milestone has developed the Sulfated Ashing Setup.
This PYRO configuration enables the analysts to add sulfuric acid to the samples and directly place crucibles into the microwave muffle furnace, without a preliminary charring step. Tedious handling of samples and operator exposure to acid fumes are totally eliminated.
The system is designed for complete operator safety, and performs the complete sulfate ashing procedure in just 1 hour. Sulfuric acid fumes released from crucibles are continuously exhausted passing through a quartz tube and an air-cooled quartz collection vessel outside the unit. The fumes are finally contained and neutralized in a dedicated acid scrubber module.

easyCONTROL Operating Software

The PYRO is controlled via a compact terminal with an easy-to-read, bright, full-colour, touchscreen display. The terminal is provided with multiple USB and Ethernet ports for interfacing the instrument to external devices and to the local laboratory network. The terminal runs a completely new user-friendly, icon-driven, multi-language software to provide easy control of the microwave run. Simply recall a previously stored method or create a new one, press ‘START’ and the system will automatically follow the user defined temperature utilizing a sophisticated PID algorithm.
Several applications, including all ASTM, USP, SEMI and ISO methods, are preloaded in the PYRO terminal. There is no need to input the number of crucibles or sample weights, as the software will automatically regulate the microwave power according to the temperature profile desired.
This assures a consistent quality of the results and simplifies the use of the instrument.

Reduce your ashing time with the right choice of Crucibles

The type and the size of the sample crucibles have a great influence over the ashing process, both in terms of time and quality of results.

ultraFAST Crucibles

The UltraFAST crucibles allow the PYRO user to dramatically reduce the overall ashing time, from start to end. They are made of an innovative material that, although chemically and thermally resistant, allows the samples to be surrounded by a constant airflow which, in turn, accelerates the ashing process. Furthermore, the cooling time is so short that there is no need to use a dessicator prior samples weighing. Just 30 seconds are enough to go from 1000°C to room temperature. The UltraFAST crucibles are suitable for the ashing of any solid sample, such as polymers, pharmaceuticals, food and feed, cokes, coals etc.

  • Shorter ashing time

  • Fast heating and cooling

  • High chemical and thermal stability

  • Constant weight

  • Long lifetime

Download ultraFAST leaflet

Self-closing Quartz Crucibles

The self-closing quartz crucibles and dedicated rack ensures fast Carbon Black Determination In Olefin Plastic and high reproducibility compared with the reference method ASTM D1603, thus avoiding the use of nitrogen. The vacuum generated during the release of combustion fumes ensures perfect sealing and an inert athmosphere the quartz crucibles, allowing for complete determination of the carbon black. The self-closing quartz crucibles and microwave heating allow for carbon black determination in only a few minutes, obtaining superior data reliability and reproducibility.

  • Shorter ashing time

  • Fast heating and cooling

  • High chemical and thermal stability

  • Constant weight

  • Long lifetime

Over 90% Time Saving

SAMPLE TEMPERATURE (°C) TIME (MINUTES)
Pet Food 575 20
Milk Powder 550 20
Milk Poder 550 20
Wheat Flour 900 50
Polypropylene 650 20
PVC 900 15
Coal 750 20
Heavy Oil 550 45
Rubber Tyre 550 45

 

Over 90% Time Saving for Microwave Ashing

PYRO Sulphate Ashing


Advanced Microwave Muffle Furnace

The new Milestone PYRO is an advanced microwave ashing furnace perfectly suitable for sulphate ashing, loss on ignition (LOI), residue on ignition (ROI), fusion and all types of high-temperature reactions under controlled conditions.

Brochure

Over 90% Time Saving for Microwave Ashing

Determination of ash content is an important test performed daily in thousands of laboratories worldwide whether for process control or for preparation of other analytical processes.
While ashing is a relatively simple process, conventional muffle furnaces are often inefficient, leading to tedious and time-consuming procedures. The invention of microwave furnace for dry ashing applications has represented a breakthrough in the process and quality control of samples like polymers, petroleum, food and feeds, pulp paper and pharmaceuticals. Unique design of PYRO microwave muffle furnace ashing system eliminates equipment corrosion and acid fume pollution, greatly reducing analyst exposure to acid fumes. PYRO ashing furnace ensures usage of all available crucibles including metal, porcelain and quartz fiber. In particular, the unique Milestone UltraFAST quartz fiber crucibles are perfectly suitable for microwave diffuser and further acceleration of suphate ashing process.

  • Safety and reliability: Best microwave hardware, temperature and pressure sensors
  • Performance and throughput:. easyTEMP temperature control and advanced rotor technology
  • ● Ease of use and control: EasyCONTROL operating software
  • ● Expertise and know-how: 30-years experience at your lab with the Milestone Connect
  • ● Flexibility: Rotor-based digestion system for hundreds of applications.

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Rugged and durable construction
STANDARD 1 YEAR WARRANTY!

While ashing is a relatively simple process, conventional muffle furnaces are often inefficient, leading to tedious and time-consuming procedures. The advent of microwave technology for dry ashing applications has represented a breakthrough in the process and quality control of samples like polymers, petroleum, food and feeds, pulp paper and pharmaceuticals.

LARGEST MICROWAVE CAVITY

Equipped with a full stainless steel door, the new Milestone PYRO microwave cavity has a volume in excess of 70 liters, thus allowing the use of a large muffle which in turn enhances the sample throughput. Additionally, a large cavity ensures that the outer temperature of the PYRO remains very low, even when the inner temperature of the furnace is in excess of 1.000°C.

TEMPERATURE CONTROL

The new Milestone PYRO is equipped with the most advanced yet easy to use temperature sensors for complete control of the ashing conditions. These NIST-traceable sensors allow rapid verification and calibration of the furnace temperature for ISO and GLP procedures.

HIGHEST POWER

The PYRO is equipped with two 950 Watt magnetrons for a total of 1900 Watt making it the most powerful microwave muffle furnace system available in the market. The system additionally employs a rotating diffuser that evenly distributes the microwaves throughout the cavity, assuring a uniform temperature is achieved inside the furnace

METHOD COMPLIANCE

The PYRO meets or exceeds the equipment requirements for electrically heated furnaces in the following methods: ASTM, USP ROI 281 and LOI 733, AOAC, FDA, ISO and DIN. It also meets or exceeds the requirements for applications listing a microwave heated furnace in the following methods: ASTM D5630-94 and ASTM D1506-94b.

A dedicated configuration for every need

The PYRO is available in 3 different and interchangeable configurations: ultrafast heating setup, high sample throughput setup and sulfated ashing setup; it is therefore the most flexible and adaptable microwave muffle furnace available in the market.

Sample

Charring step

Sample with sulfuric acid

At the completion of the ashing process

Sulphated Ashing Set-up

Ashing of pharmaceutical, polymers, and food samples often involves the use of sulfuric acid. Hot sulfuric acid vapors are hazardous to analysts and corrosive to equipment. Additionally, sulfate ashing methods are labor-intensive and time-consuming, requiring manual fuming of the acid and 8-12 hours to be completed. To overcome these issues, Milestone has developed the Sulfated Ashing Setup.
This PYRO configuration enables the analysts to add sulfuric acid to the samples and directly place crucibles into the microwave muffle furnace, without a preliminary charring step. Tedious handling of samples and operator exposure to acid fumes are totally eliminated. The system is designed for complete operator safety, and performs the complete sulfate ashing procedure in just 1 hour. Sulfuric acid fumes released from crucibles are continuously exhausted passing through a quartz tube and an air-cooled quartz collection vessel outside the unit. The fumes are finally contained and neutralized in a dedicated acid scrubber module.

easyCONTROL Operating Software

The PYRO is controlled via a compact terminal with an easy-to-read, bright, full-colour, touchscreen display. The terminal is provided with multiple USB and Ethernet ports for interfacing the instrument to external devices and to the local laboratory network. The terminal runs a completely new user-friendly, icon-driven, multi-language software to provide easy control of the microwave run. Simply recall a previously stored method or create a new one, press ‘START’ and the system will automatically follow the user defined temperature utilizing a sophisticated PID algorithm.
Several applications, including all ASTM, USP, SEMI and ISO methods, are preloaded in the PYRO terminal. There is no need to input the number of crucibles or sample weights, as the software will automatically regulate the microwave power according to the temperature profile desired.
This assures a consistent quality of the results and simplifies the use of the instrument.

Over 90% Time Saving

SAMPLE TEMPERATURE (°C) TIME (MINUTES)
Pet Food 575 20
Milk Powder 550 20
Milk Poder 550 20
Wheat Flour 900 50
Polypropylene 650 20
PVC 900 15
Coal 750 20
Heavy Oil 550 45
Rubber Tyre 550 45

 

Advanced Flexible Microwave Synthesis Platform

flexiWAVE


Advanced Flexible Microwave Synthesis Platform

Milestone has developed the duoPUR and subPUR, sub-boiling distillation systems which allow laboratories to make their own high purity acids at dramatically reduced costs.

Brochure

Complete your reactions
in minutes instead of hours!

The new Milestone flexiWAVE overcomes the limitation of conventional microwave synthesis reactors, as it consists of a single microwave platform that, in combination with specific accessories, allows the chemists to perform classic glassware and high pressure synthesis, as well as solid-phase reactions.

  • Enhanced selectivity

  • Improved yields

  • Lower by-products formation and sample contamination

  • Reduced energy consumption

  • Reduced quantity of sample/chemicals (“atom economy”)

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Last generation, dedicated microwave platform

While other manufacturers use molded plastic, Milestone uses 18/8 stainless steel construction throughout which creates the most durable, reliable, and safe microwave system available.

Largest Microwave Cavity

The flexiWAVE's microwave cavity has a volume in excess of 70 litres, by far the largest currently available. A large cavity allows the chemist to easily configure many different reactions setup in a very flexible environment. Starting from the classic synthesis glassware moving to high-pressure vessels working -alone or in parallel configuration, a large cavity is also fundamental to perform solid phase synthesis tasks.

Highest Microwave Power

The flexiWAVE is equipped with two 950 Watt magnetrons for a total of 1900 Watt making it the most powerful microwave platform system available for organic and inorganic synthesis.

Build-in Exhaust System

The flexiWAVE actually acts as a relatively small fume hood, as it incorporates a powerful exhaust system, which cools the outer surface of the reactors and provides a safe and efficient removal of vapors from the microwave cavity.

Best Reaction Control

The most advanced yet easy to use reaction sensors enable the complete control of the reaction process. Temperature can be monitored by fiber optic and infrared sensors. When performing parallel reactions, a contact-less sensor is used to control each and every vessel, and the actual temperature values are shown on the instrument control terminal, allowing an instant visual check of the reaction conditions.

MW Field Homogeneity

The system employs a rotating diffuser that evenly distributes the microwaves throughout the cavity. High power coupled with the diffuser enables very fast and homogeneous heating of samples.

Magnetic Stirring

A magnetic stirrer is built-in in the flexiWAVE system. It is designed to ensure vigorous stirring of the solutions in all vessels, independently on their position in the cavity, thus assuring reliable and consistent results.

The Best Things Comes In Three

Classic Glassware

The flexiWAVE has been designed and engineered as a ‘microwave platform’, where all types of commonly used glassware can be used.
This clearly results in a very flexible system, with a wide range of applications capabilities. The Classic Glassware setup, for instance, provides the suitable apparatus for a full reaction optimization, for research or teaching purposes.
It allows the chemists to perform synthetic reactions under reflux and subsequently, any chemical reaction currently carried out with hot plates, heating mantles or oil baths, could be rapidly improved by adopting microwave technology.

  • Conventional Synthesis in Microwave Cavity

  • Destillation

  • Reflux

  • Reagent Addition

  • Easy Sampling

  • Adapter

     

  • Fiber optic temperature sensor
  • Infrared temperature sensor
  • 500 mL glass flask
  • Weflon support
  • Magnetic stirrer

High-Pressure

Stubborn reactions are typically carried out in refluxing conditions, using high boiling solvents such as xylenes, 1,2-dichlorobenzene and N-methyl pyrrolidone.
High boiling solvents are then difficult to remove upon workup, especially as reaction scale increases.
The High-Pressure setup is capable of replacing reflux devices, moving from high boiling solvents to low boiling solvents. Moreover, high temperature reactions (up to 300 °C) can be used. The benefits are well known and documented in terms of easier work-up and products purity.
Up to 15 high-pressure vessels may be used simultaneously for parallel synthesis.

  • High Pressure and Temperature

  • Faster Reaction Rate

  • Switching from High Boiling Point Solvent to Lower One

  • Single-Vessel or Parallell Synthesis

  • Adapter

     

  • Rotating high-pressure carousel
  • High-pressure 100 ml vessel
  • Infrared Temperature sensor
  • Magnetic stirrer

Solid-Phase

Heating heterogeneous reaction mixtures, thick media or solid phase systems suffers of inhomogeneous temperature distribution and stirring difficulties using conventional microwave instruments. The innovative Solid-Phase setup offers the unique capability of physically rotating the reaction vessel, to achieve very homogenous bulk heating of slurries, viscous and solid reaction mixtures media. The reaction temperature is controlled by a contact-less infrared sensor. Furthermore, the Solid-Phase setup allows operations under normal atmosphere, inert gas, and vacuum. Functionalization and modifications of materials, polycondensation, coating, and dehydration of natural oils are some of the most common applications.

  • Homogeneous Heating of Solid Mixture

  • No Wall Effect

  • Easy Removal of Volatile By-Products

  • Solution Concentration During the Reaction Process

  • Vacuum port

     

  • 45° tilted rotating glass reactor (2,5 L or 300 mL)
  • Infrared Temperature sensor

EasyCONTROL
Operating Software

The flexiWAVE is controlled via a compact terminal with an easy-to-read, bright, fullcolour, touchscreen display. The terminal is provided with multiple USB and Ethernet ports for interfacing the instrument to external devices and to the local laboratory network. The terminal runs a completely new user-friendly, icon-driven, multi-language software to provide easy control of the microwave run. Simply recall a previously stored method or create a new one, press ‘START’ and the system will automatically follow the user defined temperature utilizing a sophisticated PID algorithm. Furthermore, all reaction parameters can be modify “on-the-fly”, thus assuring the highest flexibility of operation..

SafeVIEW System

The flexiWAVE SafeVIEW is a high definition digital camera interfaced with the instrument terminal. It allows the chemist to monitor the progress of the chemical reaction whilst fully protected by the all-stainless steel door of the instrument. A video of the entire run is shown in real time allowing to follow the reaction and the additions of reagents to be followed.

The Game Changer in Microwave Assisted Synthesis

synthWAVE


The Game Changer in Microwave Assisted Synthesis

The Milestone synthWAVE is designed for safe, reliable and reproducible scale-up of microwave enhanced chemical reactions. The synthWAVE is capable of higher temperature and pressure than any other microwave reactors.

Play Video

Brochure

Unique technology
for high pressure capabilities

Milestone synthWAVE features the unmatched Single Reaction Chamber (SRC) patented technology that ensures scale, reaction screening, highest temperature and pressure. It is able to handle single or multiple reactions at temperatures up to 300 °C and pressures up to 199 bar.
Incredibly easy to use, the synthWAVE with SRC technology allows the chemist to run large-scale batch and parallel reactions like never before. Small-scale synthesis methods are easily transferred to the SynthWAVE.

  • Minutes, not hours

  • Improved yields

  • Enhanced selectivity

  • Low energy consumption

  • Sustainable approach

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

New horizons in microwave chemical synthesis

  • Stirrer

  • Reaction Chamber

  • Waveguide

  • Magnetron

SRC Technology

Milestone’s unique Single Reaction Chamber (SRC) technology overcomes the limitations of current microwave synthesis instrumentation. A PTFE lined, 1 L stainless steel reaction chamber serves also as microwave cavity. The design of the microwave source perfectly match the cavity shape for optimum microwave distribution and fast, even heating. The chamber is prepressurized with gas to prevent boiling of the solution, and is equipped with mechanical and magnetic stirrers. The microwave cavity is water cooled, which greatly reduces reaction cooling time and increases productivity.

Safety

Like all Milestone products, the synthWAVE has been designed with operator safety of paramount importance. A thick acrylic shield surrounds the work area, and it lowers into position automatically as the chamber is closed. A microwave run cannot be started unless the chamber clamp is in position, and the clamp cannot be released until the chamber is cool, and pressure has been released. The PID controller continuously monitors temperature and pressure, instantaneously adjusting microwave power to control even highly exothermic reactions.

Software-Controlled Stirrer

The synthWAVE features a powerful stirrer, which ensures vigorous stirring in the 1L PTFE vessel, or in all vials whenever a rack is used, thus assuring reliable and consistent results.

How the syntWAVE works

  • Acrylic Safety Shield

     

  • Overhead Stirrer
  • Gas Outlet
  • Gas Inlet
  • In-situ sampling easily and conveniently sample reaction products at any time during the experiment.
  • Analog pressure gauge
  • 15-place rack
  • Temperature sensor
  • PTFE 1 L vessel
  • Exhaust system
  • Clamps
  • Dawar flasks
  • Control terminal

Rack and Vials

Reactions can be carried out directly in the 1L PTFE vessel, or in multiple vials. Vials are available in glass (disposable), quartz or PTFE, fitted with loose PTFE caps to ensure pressure equalization. Available rack configurations include 4, 5, 15 and 22 positions. The synthWAVE sample racks fit easily on a balance, so reagents can be weighed directly into vials already loaded into a rack. No vessel assembly or disassembly is required, and with the disposable glass vials, no cleaning step is needed, greatly increasing work efficiency

Faster Screening

Multiple reactions are carried out simultaneously under exactly the same temperature and pressure conditions - even using different solvents. Quickly and easily evaluation of different catalysts, solvents and reaction conditions.

Operate in Modified Conditions

Simply add an inert gas to achieve an inert environment. Add hydrogen or oxygen to produce a reducing or oxidizing atmosphere respectively. Speed up reactions with gas molecule insertion using gases such as CO or CO2.


EasyCONTROL Operating Software

synthWAVE is controlled via a compact terminal with an easy-to-read, bright, fullcolour, touchscreen display. The terminal is provided with multiple USB and Ethernet ports for interfacing the instrument to external devices and to the local laboratory network.
The terminal runs a completely new user-friendly, icon-driven, multi-language software to provide easy control of the microwave run. Simply recall a previously stored method or create a new one, press ‘START’ and the system will automatically follow the user defined temperature utilizing a sophisticated PID algorithm. Furthermore, all reaction parameters can be modify “on-the-fly”, thus assuring the highest flexibility of operation.

Total Fat Determination in Foodstuffs

Ethos X for Fat Determination


Total Fat Determination in Foodstuffs

Traditional fat extraction methods are very labor intensive and time-consuming. Our ETHOS X performs determination of fat content in milk products simultaneously in just 90 minutes, having equivalent results with those obtained by reference fat determination methods.

Brochure

Total Determination of fat content in just 90 minutes!

Traditional methods lead to the use of large amounts of solvents to remove fat from a sample matrix, resulting in low cost-effectiveness.
As an example, conventional fat extraction of pretreated cheese usually requires 3 hours and over 100 mL of solvent per sample. The standard fat extraction methods are not efficient in matter of cost and time, also exposing laboratory technicians to dangerous solvents.
To overcome these limitations, Milestone has developed a fast yet accurate microwave-based technology, which allows the chemist to carry out the simultaneous determination of fat content in 12 milk and milk products samples in just 90 minutes, with equivalent results of those obtained with reference techniques like Rose-Gottlieb method, Weibull-Stoldt or Schmid-Bondzynski-Ratzlaff method. The main advantages of this technology include:

The analytical procedure for The analytical procedure for flavors and fragrances extraction from plants or spices comprises two steps: extraction by steam distillation or hydro-distillation, and analysis by GC or GC-MS. While the analysis step requires just few minutes, extraction takes several hours, using a standard procedure based on the Clevenger (1928 year!).
To address these limitations, Milestone has developed the new ETHOS X for the solvent-less extraction of natural products. It takes advantage of the unique microwave selective heating mechanism. The internal heating of the water within the sample distends its cells and leads to rupture of the glands and oleiferous receptacles. This process thus frees essential oil, and the flavors extracts is evaporated by the in-situ water of the plant material.

  • 12 samples simultaneously

  • 75% solvent reduction

  • Up to 10 gram of sample amount

  • Combined hydrolysis and extraction

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Perfomances Comparison

The traditional fat extraction methods are very labour intensive and time-consuming.
Compare the performances of the ETHOS X microwave-based technology to those of the Reference Method

A New Method

The ETHOS X determines total fat in milk and milk products as a result of two working steps. In the first step sample hydrolysis and extraction take place simultaneously at relatively elevated temperature and pressure conditions. In the second step a known aliquot of the solvent with the extracted fat is evaporated allowing the chemist to weigh and measure the fat content.

Hydrolysis & Extraction

Up to 12 samples can be analyzed simultaneously, with a typical sample amount up to 10 gram. 10 mL of diluted acid and 25 mL of solvent are used for most matrices. The combined hydrolysis and extraction process takes place at 125°C and requires approximately 50 minutes or less.
Temperature is monitored and controlled in each and every vessel by using a unique combination of fiber optic and infrared temperature sensors. The ETHOS X built-in magnetic stirrer assures an even heating and temperature uniformity in all vessels, as well as intensive mixing between the aqueous and the solvent phases.

Typical combined hydrolysis and extraction temperature profile. Acid: diluted sulfuric acid or diluted hydrochloric acid. Solvent: cycle-hexane or petroleum ether.

Solvent Evaporation

A measured aliquot of the solvent with the extracted fat is evaporated in disposable cups, located in a dedicated rotor, in just 15 minutes.
The evaporation process takes place under controlled temperature and vacuum conditions, to avoid the thermal degradation of the fat content. At the completion of the evaporation, the fat content is immediately weighed on a balance which is directly interfaced with the ETHOS X, taking advantage of the extremely short cooling time of the disposable cups. The instrument operating software automatically calculates the fat content and all the statistics associated with the analysis of the 12 samples analyzed

Typical evaporation temperature profile.

High Technical Performance

Microwave hardware

The ETHOS X microwave cavity has a volume in excess of 70 liters, by far the largest currently available. With an installed power of 1900 Watt, the ETHOS X is the most powerful microwave platform system available for extraction. A rotating diffuser evenly distributes the microwaves throughout the cavity. A magnetic stirrer is built-in in the ETHOS X system. It is designed to ensure vigorous stirring of the solutions in all vessels. Finally, the ETHOS X actually acts as a fume hood, as it incorporates a powerful exhaust system.

User Interface

The new Milestone ETHOS X is equipped with the most advanced yet easy to use reaction temperature and pressure sensors for complete quality control of the extraction conditions. It is controlled via a compact terminal with an easy-to-read, bright, full-color, touchscreen display. The terminal runs a completely new user-friendly, icon-driven, multi-language software to provide easy control of the microwave run.

Microwave Green Extraction of Natural Products

Ethos X for Natural Products


Microwave Green Extraction of Natural Products

Available in two different and interchangeable configurations, for fragrances and for flavors, the ETHOS X takes advantage of the unique microwave microwave hydrodiffusion and gravity technique for high-quality essential oils extraction.

Brochure

Wish to get high-quality essential oils?

The analytical procedure for The analytical procedure for flavors and fragrances extraction from plants or spices comprises two steps: extraction by steam distillation or hydro-distillation, and analysis by GC or GC-MS. While the analysis step requires just few minutes, extraction takes several hours, using a standard procedure based on the Clevenger (1928 year!).
To address these limitations, Milestone has developed the new ETHOS X for the solvent-less extraction of natural products. It takes advantage of the unique microwave selective heating mechanism. The internal heating of the water within the sample distends its cells and leads to rupture of the glands and oleiferous receptacles. This process thus frees essential oil, and the flavors extracts is evaporated by the in-situ water of the plant material.

  • Fast, Solvent-less extraction

  • No work-up

  • High extracts purity

  • No thermal degradation

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Testimonal

INRA AGROSCIENCE NATIONAL RESEARCH INSTITUTE

Prof. Farid Chemat, University of Avignon, France

Prof. Farid Chemat is full professor of chemistry and director of Green Extraction Laboratory where 200 international scientists deal with innovative techniques.


Choose your preferred setup

Two Different Configurations

Fragrances Extraction

The Fragrances configuration for ETHOS X is based on the solvent-free microwave extraction (SFME) technology for the rapid extraction of essential oils from aromatic herbs, spices and dry seeds, developed at the Laboratory of Chemistry of Natural Substances and Food Sciences at the Université de la Réunion, France (European patents EP 1 439 218, EP 1 618 798 and EP 1 629 725). The ETHOS X performs solvent-free microwave extraction at atmospheric pressure of fragrances, such as essential oils, in plant material. The method involves placing the sample in the microwave reactor, without any added solvent or water. A cooling system outside the microwave continuously condenses the vapors which are collected in a dedicated fragrances glassware. The excess of water is refluxed back to the extraction vessel to restore the in-situ water of the sample.
Once the essential oils have been extracted, they can be analyzed directly by GC-MS without any preliminary clean-up or solvent exchange steps. High quality fragrances are obtained without residual solvents, contaminants and artifacts.

Discover yields

Flavors Extraction

The Flavors configuration is based on the microwave hydro-diffusion and gravity technology (MHG), a new and green method of essential oils extracted from different kinds of aromatic plants, which led to the grant of the European patent EP 1 955 749. The microwave hydro-diffusion and gravity technology (MHG) is an original “upside down” microwave alembic, combining microwave heating and earth gravity at atmospheric pressure. This technology allows the flavors to diffuse outside the plant material, dropping by earth gravity out of the microwave reactor. A cooling system outside the microwave oven continuously condenses the extract. The extraction process takes place without the need of distillation and evaporation, some of the most energy demanding operations commonly required. Whereas traditional processes are carried out in 3 hours or more, solvent-free microwaves hydro-diffusion plus gravity requires less than 30 minutes.
Once the essential oils have been extracted, they can be analyzed directly by GC-MS without any preliminary clean-up or solvent exchange steps. The ETHOS X in the Flavors configuration allows the microwave extraction of natural flavoring substances and non-volatile compounds such as pigments, flavonoids and carotenoids.

Discover yields

Unique Microwave Platform

The new Milestone ETHOS X microwave cavity has a volume of 70 liters, by far the largest currently available, allowing the user to configure glass reactors from 2 up to 12 liters of volume.

2, 5 and 12 liters glass reactors for fragrances and flavors

Highest Microwave Power

The ETHOS X is equipped with two 950 Watt magnetrons for a total of 1900 Watt making it the most powerful microwave platform system available for extraction.

Best Extraction Control

 The ETHOS X is equipped with the most advanced yet easy to use contact-less temperature sensor for a complete control of the extraction process.

Build-In Exhaust System

The ETHOS X acts as a fume hood, as it incorporates a powerful exhaust system, which cools the reactors.

New User-friendly Software

Compact terminal with an easy-to-read, bright, full-color, touchscreen display. The terminal runs a completely new icon-driven, multi-language software.

Advanced Microwave Extraction System for Environmental Laboratories

Ethos X Enviromental


Advanced Microwave Extraction System for Environmental Laboratories

Microwave-assisted solvent extraction offers superior lab efficiency in the determination of organic pollutants with microwave green extraction technique. Typical applications include chlorinated pesticides, semi-volatile organics, PAHs, PCBs, chlorinated herbicides, phenols, organophosphorus pesticides, dioxins and furans

Brochure

Designed by you.
Developed for you.

Determination of organic pollutants in environmental matrices is a common task for thousands of laboratories worldwide, as it leads to controlling and protecting our environment from high levels of contaminants. This analysis is often done to evaluate the effectiveness of a remediation process, to assess the contamination in waste, in waste landfills and for general environmental monitoring. Therefore, every day environmental laboratories deal with several challenges to ensure high quality data and fast turnaround time while maintaining their competitiveness.
Extraction of pollutants from solid matrices is often performed with techniques that limit the productivity and have high running costs. Many laboratories still use the Soxhlet method that was developed in 1879!
Milestone listened to the needs of environmental laboratory professionals by developing the ETHOS X with the fastEX-24 rotor, which allows for simultaneous extraction of 24 samples in 40 minutes with minimal solvent usage. By using large volume disposable glass vials, the fastEX-24 rotor simplifies handling and allows to achieve lower detection limits.

  • High throughput. - 24 samples in 40 minutes. 

  • Superior return of investment - Substantial reduction in solvent. 

  • Simple handling - Disposable glass vials. 

  • Consintency & Reproducibility - Consistent and reproducible results. 

  • Safety & Reliability

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Achieving lower detection limits
with higher sample amount

The ETHOS X with fastEX-24 rotor extracts up to 30 grams of sample with minimal solvent volume, helping analysts to accomplish their tasks.
The Milestone fastEX-24 rotor uses disposable glass vials, eliminating the need for cleaning and the possibility of memory effect between different runs. The 100 mL vials can accommodate the extraction of a large sample amount. The easy to handle and affordable cost of the vials leads to high productivity at a very low running cost.

24 samples in < 1 hour!

Easy of use with disposable glass vials

The ETHOS X operation is simple: samples are loaded into large volume disposable glass vials with appropriate solvent mixture, placed into the Weflon vessel and sealed. The unique Weflon material ensures homogeneous heating in all vessels, therefore increasing extraction efficiency even when different matrices are processed simultaneously, which enhances the lab's workflow. The accurate contactless temperature sensor ensures full control of the extraction cycle in all positions and displays realtime the temperature of all samples on the dedicated user interface. The 100-mL glass disposable vials accommodate large sample amounts of up to 30 g, enabling lower detection limits with minimal solvent volume. In addition, the memory effects often observed with polymer vessels or with other technologies are eliminated. This is a valuable feature for trace analysis of challenging species such as dioxins.

Producivity

Although new extraction technologies have been developed in recent years, they have fallen short on addressing the needs of environmental labs. The ETHOS X with fastEX-24 overcomes productivity limitations of other conventional approaches by enabling the extraction of a large number of samples in a single workday. Other technologies process one sample at a time sequentially, requiring long extraction cycles. The ETHOS X simultaneously processes 24 samples in only 40 minutes and eliminates cleaning steps by using disposable glass vials. The graphic below compares the typical daily productivity using the Milestone ETHOS X, Sequential Pressurized Liquid Extraction and Soxhlet.

Productivity based on 8 hours working shift. 24 samples requiring 40 minutes with the ETHOS X, 240 minutes with Sequential Pressurized Liquid Extraction and multiple hours with Soxhlet.


Consistency

Data quality and reliability are key features for environmental labs. The ETHOS X with the fastEX-24 rotor provides fast, accurate and precise analysis. Weflon vessels allow to simultaneously process various matrices ensuring optimal extraction efficiency. In addition, the unique design of the fastEX-24 rotor with its large volume disposable glass vials (100 mL) eliminates cross contamination and memory effect, providing reproducible results.

Milestone ETHOS X recovery study and comparison vs Soxhlet for various organic compounds.

Compliance

Several official methods describe the use of microwave closed-vessel technology to enhance the extraction efficiency of organic pollutants, such as US EPA 3546, ASTM and other national methods. The top-right table reports the typical conditions used in US EPA 3546. The ETHOS X with fastEX-24 further enhances the performance of microwave technology for the extraction of water-insoluble or slightly water-soluble organic compounds from soils, clays, sediments, sludges, and solid wastes. In fact, the ETHOS X with fastEX-24 can be used for solvent extraction of chlorinated pesticides, semi-volatile organics, PAHs, PCBs, chlorinated herbicides, phenols, organophosphorus pesticides, dioxins and furans.


Greater return on investment

The competitive nature of the environmental analysis market requires today's laboratories to have innovative solutions that provide faster turnaround times. With throughput capabilities of 24 samples in only 40 minutes, the ETHOS X with fastEX-24 reduces overall analysis costs by increasing productivity. The combination of lower solvent volumes, less maintenance needs, and the use of inexpensive disposable glass vials decreases the cost per sample to enhance your lab's competitiveness and profitability.

Flexibility

Elemental analysis by atomic spectroscopy is a standard analysis in environmental laboratories. The ETHOS X enables digestion of environmental matrices such as soils, sediments, wastewater in full compliance with official methods like US EPA. Several options are available to match the laboratory requirements.

Samples submitted for GC and HPLC analysis require pre-treatment

Ethos X for GC and HPLC Analysis


Samples submitted for GC and HPLC analysis require pre-treatment

The fundamental step in sample pretreatment is compound extraction from the sample matrix. This is the least evolved -many people still use the Soxhlet extraction method invented in 1879-, most error-prone step in the overall analytical procedure.

Brochure

Several configurations
to accomplish a wide range of applications

The use of microwave energy to accelerate solvent extraction procedures was first described by Ganzler et al. in 1984. These researchers used polar, microwave absorbing solvents or mixtures to extract crude fat from food and pesticides from soil matrices. Microwave extraction rates were found to be significantly faster, with recoveries comparable or superior to traditional Soxhlet extraction, and with a substantial reduction of the amount of solvent required.
New Milestone ETHOS X is an advanced microwave extraction system offering the best technology currently available for GC or GC-MS and HPLC analysis

  • Reliable GC or GC-MS analysis

  • High sample throughput

  • Low running costs

  • ● Efficiency and consistency

  • Simplicity

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

The New Milestone Ethos X

Fast

Microwave extraction is completed in just few minutes. The Milestone ETHOS X can simultaneously process multiple samples in a matter of minutes. Microwave assisted extraction uses closed vessels to heat the extraction solvent above its atmospheric boiling point. The elevated temperature increases the solubility of the analytes of interest and lowers the viscosity of the solvent, allowing it to better penetrate the matrix. This reduced extraction times.

Easy

An important feature of the ETHOS X system is that it easily adapts to existing extraction chemistry. This is accomplished through the use of a unique, patented material, called Weflon. Without Weflon, extractions could only be performed with polar solvents (Acetone, Methanol, etc.) or mixtures of polar and non-polar solvents, because non-polar solvents are not heated by microwaves. Weflon eliminates this problem by acting as a coupling agent. Weflon stir bars are heated by microwaves and they subsequently transfer this heat to the non-polar solvent.

Effective and Consistent

Microwave extraction produces equal or higher analyte recoveries than older methods. Thanks to a combination of higher extraction temperatures, closed vessels, magnetic stirring, and precisely controllable temperature conditions, users of microwave extraction can expect a better quality of the results. The homogeneity of the microwave field and the precision of the temperature control are key elements in microwave extraction.

Economical

Lower solvent usage reduces the costs of solvent purchase and disposal. Microwave extractions are carried out in closed, sealed vessels. The matrix is constantly bathed with hot solvent in a self-promoting reflux action with no loss of volatile analytes or solvent. The use of closed vessels, with the speed and efficiency of microwave heating, allows extractions to be performed with significantly less solvent, without sacrificing accuracy or precision. The simplicity of the microwave technique reduces the attended labor time and increases overall productivity.

  • FastEX-24 configuration for extracting water insoluble or slightly water soluble organic compounds from soils, clays, sediments, sludges, and solid wastes.

  • SR-12 for hydrolysis and extraction for milk and milk products applications

  • RAR-12 for solvent evaporation for fat content determination.

  • SK-12 rotor for microwave solvent extraction.

Higher microwave power for faster vessel heating

Pressure-responsive door schematics.

Direct and contact-less temperature control in all vessels.

Largest Microwave Cavity

The ETHOS X microwave cavity has a volume in excess of 70 liters, by far the largest currently available. Why is this important? Firstly, extraction rotors with more sample positions can be accommodated, improving productivity. Secondly, the microwave unit is inherently much safer, because a larger cavity better contains gases escaping from vessels, should there be a sudden over pressurization.

Highest Microwave Power

Equipped with two 950 Watt magnetrons for a total of 1900 Watt, ETHOS X is the most powerful microwave extraction system available in the market today. The system additionally employs a rotating diffuser that evenly distributes the microwaves throughout the cavity. High power coupled with the diffuser enables very fast heating of high throughp

Pressure-Responsive Door

The ETHOS X's stainless steel door features an innovative opening and self-resealing mechanism. In case of a sudden over-pressurization of the cavity, the door slightly opens for rapid pressure release and the microwave power is instantaneously cut off. Immediately afterward, the door is pulled back, resealing the cavity. An automatic door locking system does not allow the user to open the ETHOS X door during the run.

Temperature and Pressure Sensors

The most advanced yet easy to use reaction sensors are installed for complete quality control of the extraction conditions. Direct temperature and pressure control are used in a single reference vessel. In all vessels, contact-less temperature is used combined with a contact-less pressure sensor that monitors and controls all vessels simultaneously, preventing any leakage or venting.

EasyCONTROL
Operating Software

The ETHOS X is controlled via a compact terminal with an easy-to-read, bright, full-color, touchscreen display. The terminal is provided with multiple USB and Ethernet ports for interfacing the instrument to external devices and to the local laboratory network. The terminal runs a completely new user-friendly, icondriven, multi-language software to provide easy control of the microwave run. Simply recall a previously stored method or create a new one, press ‘START’ and the system will automatically follow the user defined temperature utilising a sophisticated PID algorithm. Several applications, including all US EPA and ASTM methods available, are preloaded in the ETHOS X terminal. There is no need to input the number of samples or weights being extracted, as the software will automatically regulate the microwave power accordingly. This assures a consistent quality of extraction and simplifies the use of the instrument.

Environmentally clean extraction technique

Jasco SFE - Supercritical Fluid Extraction


Environmentally clean extraction technique

Supercritical fluid extraction (SFE) uses a supercritical fluid as an extraction solvent. Selective extraction can be made by exploiting the properties of differential solubility of target analytes in a wide variety of matrices.

Brochure

Jasco SFE

Supercritical Fluid Extraction employs a supercritical fluid, most commonly CO2, as the A mobile phase solvent for the extraction. The intrinsic low viscosity and high diffusivity of supercritical CO2 has rendered SFE a faster extraction and higher efficiency technique when compared to traditional liquid extraction. This provides faster flow rates and thus faster extraction times without the requirement for a higher pressure system. The addition of a co-solvent to the CO2 flow can help tune the strength further. The extraction oven can offer temperatures up to 100°C. Lastly after the extraction vessel is the back pressure regulator, which provides the back pressure requirement to keep the CO2 supercritical, and is an integral part of the performance of the extraction.

SFE Benefits

  • 1. Selectivity

    CO2 polarity varies greatly depending upon the pressure it is exposed to. This makes CO2 a tunable solvent which allows the user to find the precise conditions for extraction of the compounds of interest while leaving unwanted compounds behind. This inherent trait of CO2 greatly reduces the need for post extraction cleanup that would be necessary with most solvent extractions.

  • 2. No residual solvents

    Given the gaseous state of CO2 at atmospheric conditions, the resulting extract does not require the long rotovap time needed to dry solvent extracted analytes.

  • 3. Faster

    Given the high diffusivity and low viscosity of CO2 in its supercritical state the extractions typically take a fraction of the time compared to solvent extractions.

  • 4. Higher Yield

    Due to increased temperature and pressure, supercritical CO2 can penetrate many matrices that solvents cannot thereby allowing for greater surface area contact which in turn increases yield.

  • 5. Low Operating Cost

    Cost per extraction is significantly lower as the cost of CO2 is much lower than the equivalent amount of solvent.

  • 6. Environmentally Friendly

    Cost per extraction is significantly lower as the cost of CO2 is much lower than the equivalent amount of solvent.

  • When compared to Soxhlet extractions, supercritical fluid extractions have proven to be capable of providing extractions up to 25 times faster with equivalent recovery while using up to 30 times less solvent.

Product Specialist

Mats Grapne

"More than 30 years experience in the field of HPLC, Spectroscopy and other analytical equipments. Contact me if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
0709-119301

Analytical SFE

  • ●  The analytical CO2 pump offers built-in peltier cooling to maintain a stable CO2 flow yielding excellent extraction time reproducibility. Automatic, built-in shut-off valves close the CO2 inlet and outlet and isolate the pumps for quick and simple priming when not pumping.

  • ●  The system can be configured for CO2 only or 1-10 co-solvents, 1-10 extraction vessels for the vessel volumes listed above and 1, 6, 12 or 54 fractions.

System             Extractions vessel            CO2 Flowrate

Analytical         1 ml, 5 ml, 10 ml               0,2-10 ml

Hybrid SFE

  • ●  The hybrid CO2 pump offers a flow range from 0.5 to 20 mL/min covering both analytical 10mL vessels up to semi-prep 100 mL vessels. Automatic, built-in shut-off valves close the CO2 inlet and outlet and isolate the pumps for quick and simple priming when not pumping.

  • ●  The system can be configured for CO2 only or 1-10 co-solvents, 1-10 extraction vessels for the vessel volumes listed above and 1, 6, 12 or 54 fractions.

System             Extractions vessel            CO2 Flowrate

Hybrid             10 ml, 50 ml, 100 ml         0,5-20 ml

Semi-Prep SFE

  • ●  The semi-prep CO2 pump offers a flow range from 3 to 50 mL/min covering 50 mL vessels up to 200 mL vessels (largest vessels not availible yet). Automatic, built-in shut-off valves close the CO2 inlet and outlet and isolate the pumps for quick and simple priming when not pumping.

  • ●  The system can be configured for CO2 only or 1-10 co-solvents, 1-10 extraction vessels for the vessel volumes listed above and 1, 6, 12 or 54 fractions.

System           Extractions vessel            CO2 Flowrate

Semi-Prep      50 ml, 100 ml, (200 ml)    3-50 ml

Preparative SFE

  • ●  The Prep CO2 pump offers a flow range from 5 to 150 mL/min covering 500 mL vessels up to 2L vessels (largest vessels not availible yet). Automatic, built-in shut-off valves close the CO2 inlet and outlet and isolate the pumps for quick and simple priming when not pumping.

  • ●  The system can be configured for CO2 only or 1-10 co-solvents, 1-10 extraction vessels for the vessel volumes listed above and 1, 6, 12 or 54 fractions.

System           Extractions vessel            CO2 Flowrate

Prep               (500 ml, 1 L, 2 L)               5-150 ml

The basic model of CDS's 6th generation Pyroprobes

CDS Pyroprobe 6150


The basic model of CDS's 6th generation Pyroprobes

The 6150 is equipped with Drop-In-Sample-Chamber (DISC) technology with easy sample loading and 1.5% RSD. 

Brochure

System description

Pyrolysis is a thermal decomposition process of organic material at elevated temperatures in an anaerobic environment. It involves the cleavage of large complex molecules into smaller, more analytically useful fragments by the thermal energy.

CDS Analytical released the first commercial analytical pyrolyzer (Model 100) in late 60s, and has been proudly making world's best pyrolyzers for over 50 years. Our products have evolved through 6 generations and represent the industries highest standard.

  • Newly Designed Oven with High Temperature Valve - The newly designed valve oven guarantees the sample path is evenly heated without cold spots. A heating temperature of 350 °C assures minimal carry over.

  • Windows 10 Compatible Software - The 6th generation CDS Pyroprobe has completely redesigned software for modern PC systems. It is also backward compatible with Windows XP, Windows 7 and Windows 8.

  • Built-In Leak Check - This feature allows you to carry out pyrolysis studies with peace of mind. The self diagnosis capabilities can identify the leaking zones when attempting to trouble shoot the system.

  • Easy Maintenance - The 6200 is designed with quick access panels for easy diagnosis and quick exchange of parts to minimize instrument downtime.

  • Touch Screen Interface - The CDS 6200 Pyroprobe has the industry leading user interface through a high resolution 4.5" touch screen. 

  • Versatile Accesories - The 6200 comes with a Multi-Purpose Rail Mount (MPRM) to allow easy mounting of optional accessory modules, such as the Autosampler, 1/2" manual probe and 1//4" ribbon probe.

  • Powerful Library - The CDS library has 500+ industry standard polymers and 500+ polymer additives. This powerful library helps to address the need to identify unknown compounds from pyrolysis.

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Main Features

CDS DISC System

The 6200 is equipped with the revolutionary Drop In Sample Chamber (DISC) sample loading system. This system makes the loading of pyrolysis tubes a quick and trouble-free operation.

Easy Sample Prep

The DISC system is using a novel DISC tube to simplify the sample preparation process. No quartz wool is needed and the sample filling is as easy as dropping a straw into a drink.

Unparalleled Reproducibility

The DISC system brings an amazing 1.5% RSD for 5 run pyrolysis of Polystyrene at 600 °C by holding 0.1 °C temperature accuracy and calibrated temperature precision.

Superior Resolution

The 6000 series Pyroprobe adopts the computer aided Finite Element Analysis in the sample pathway development. The system could reach C55 for pyrolyzing Polyethylene through GC with a single quad mass-spec.

Model 6200 Pyroprobe adds in an analytical trap to enable collecting analytes using slow rate pyrolysis

CDS Pyroprobe 6200


Model 6200 Pyroprobe adds in an analytical trap to enable collecting analytes using slow rate pyrolysis

The built-in trap also expands the capability to use a reactant gas (like oxygen and air), and perform thermal desorption on sorbent tubes or larger samples. The 6200 also permits direct pyrolysis to the GC in GC carrier gas. The 6200 is equipped with Drop-In-Sample-Chamber (DISC) technology with easy sample loading and 1.5% RSD.

Brochure

System description

Pyrolysis is a thermal decomposition process of organic material at elevated temperatures in an anaerobic environment. It involves the cleavage of large complex molecules into smaller, more analytically useful fragments by the thermal energy.

CDS Analytical released the first commercial analytical pyrolyzer (Model 100) in late 60s, and has been proudly making world's best pyrolyzers for over 50 years. Our products have evolved through 6 generations and represent the industries highest standard.

  • Newly Designed Oven with High Temperature Valve - The newly designed valve oven guarantees the sample path is evenly heated without cold spots. A heating temperature of 350 °C assures minimal carry over.

  • Windows 10 Compatible Software - The 6th generation CDS Pyroprobe has completely redesigned software for modern PC systems. It is also backward compatible with Windows XP, Windows 7 and Windows 8.

  • Built-In Leak Check - This feature allows you to carry out pyrolysis studies with peace of mind. The self diagnosis capabilities can identify the leaking zones when attempting to trouble shoot the system.

  • Easy Maintenance - The 6200 is designed with quick access panels for easy diagnosis and quick exchange of parts to minimize instrument downtime.

  • Touch Screen Interface - The CDS 6200 Pyroprobe has the industry leading user interface through a high resolution 4.5" touch screen. 

  • Versatile Accesories - The 6200 comes with a Multi-Purpose Rail Mount (MPRM) to allow easy mounting of optional accessory modules, such as the Autosampler, 1/2" manual probe and 1//4" ribbon probe.

  • Powerful Library - The CDS library has 500+ industry standard polymers and 500+ polymer additives. This powerful library helps to address the need to identify unknown compounds from pyrolysis.

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Main Features

CDS DISC System

The 6200 is equipped with the revolutionary Drop In Sample Chamber (DISC) sample loading system. This system makes the loading of pyrolysis tubes a quick and trouble-free operation.

Easy Sample Prep

The DISC system is using a novel DISC tube to simplify the sample preparation process. No quartz wool is needed and the sample filling is as easy as dropping a straw into a drink.

Unparalleled Reproducibility

The DISC system brings an amazing 1.5% RSD for 5 run pyrolysis of Polystyrene at 600 °C by holding 0.1 °C temperature accuracy and calibrated temperature precision.

Superior Resolution

The 6000 series Pyroprobe adopts the computer aided Finite Element Analysis in the sample pathway development. The system could reach C55 for pyrolyzing Polyethylene through GC with a single quad mass-spec.

The Drop-In-Sample-Chamber (DISC) is a novel accessory module for the 6000 series Pyroprobes

Pyroprobe Disc Module


The Drop-In-Sample-Chamber (DISC) is a novel accessory module for the 6000 series Pyroprobes

It transforms the horizontal sample loading probe used in traditional manual pyrolysis system to a convenient vertical loading system. 

Brochure

System description

The DISC saves your precious time by reducing the sample tube loading process. When used with the filler rod, the DISC helps to reduce sample preparation time by skipping the quartz wool insertion.

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Main Features

Most Convenient Way to Load Pyrolysis Samples

It has never been easier before to load a pyrolysis tube when using the DISC chamber, thanks to the novel design of the vertical loading method.

CDS Resistively Heated Filament

The DISC chamber adopts the same legendary CDS resistive heating coil to pyrolyze your sample with the lowest thermal mass and quickest temperature ramp up rate.

Minimum Effort in Routine Maintenance

The DISC chamber is designed with the user in mind, and requires minimum maintenance. An occasional septum change is all that is needed to keep it operating properly.

Upgrade to Autosmapler

The DISC chamber is the core component of the autosampler module, and could be easily upgraded on site.

Optical Window

The DISC chamber provides an optical window for easy sample observation.

Software Compatible

The 6000 series software has embeded the DISC control option for both 6150 and 6200.

TThe 6000 series autosampler module provides hands-free and worry-free analysis for an infinite number of samples

Pyroprobe Autosampler Module


The 6000 series autosampler module provides hands-free and worry-free analysis for an infinite number of samples

The autosampler has 48 positions with capability to add samples on the go. 

Brochure

System description

The autosampler is driven by a novel hybrid mechanism, combining the reliability from the state-of-art air actuators and the precision from electronic step motors. DISC option is required to be installed with the autosampler module

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Main Features

Dynamic Loading Sequence Table (DLST)

The DLST feature allows users to dynamically add or adjust new samples to the sequence.

Heavy Duty Sample Loading Mechanism

The sample loading mechanism is made of 316 Stainless Steel, which will maximize the life span of the system.

Jam-free Vertical Loading

The autosampler module is an add-on option to the DISC. The sample is gravity fed seamlessly into the DISC chamber.

Hybrid Driving Mechanism

The autosampler module adopts a unique hybrid driving mechanism, which include two high torque air actuator and one high precision stepper motor.

Easy Maintenance

With a screw driver, the autosampler could be completely unmounted and serviced within minutes.

Great Transparency

With the transparent case, you can run the sample with confidence by observing through the autosampler in action.

A stand-alone 72 position Thermal Desorption Autosampler and sample concentrator

CDS 7550S TD


A stand-alone 72 position Thermal Desorption Autosampler and sample concentrator

Built on the 2nd generation autosampler platform, the CDS 7550S is capable of 3D positioning within 1 mm, and thanks to its unique custom calibration

Brochure

System description

It could handle 3.5" standard Thermal Desorption tube from any manufacturer. These features make CDS 7550 the most reliable Thermal Desorption autosampler available to the market. The 7550S adopts two focus modes as Pre-desorb and Pre-heat function for high humidity sample, and optional Peltier module for lighter compounds, to improve the resolution of early eluting peaks.
  • 72 Position Autosampler

  • Cryogen Free with Pre-Desorb and Pre-Heat

  • Stand-Alone Automsampler

  • High Temperature Valve Oven at max 350°C

  • Excellent TD Tube Compatibility

  • Powerful Windows Based Software

  • ● Built-in Leak Check

  • ● Optical Sensor

  • ● Precision Robotic Arm

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Main Features

72 Position Autosampler

CDS adopts a novel way to protect the TD tube by sealing in a reusable gas tight metal chamber, while waiting for the autosampler to pick up

Cryogen Free with Pre-Desorb and Pre-Heat

To improve the resolution of early eluting molecules, CDS uses a pre-desorb and pre-heat technique to mechanically confine analytes in a tiny space to improve focusing, which is more reliable than Peltier assisted focusing.

Stand-Alone Automsampler

The 7550S Thermal Desorption Autosampler has a built in focus trap and does not require a separate sample concentrator.

High Temperature Valve Oven at max 350°C

The high temperature oven (350°C) significantly extends the analyte range from VOCs to sVOCs.

Excellent TD Tube Compatibility

The autosampler can be configured to accommodate standard 1/4" x 3.5" TD tube from various manufacturers from its custom calibration interface

Powerful Windows Based Software

The software is Windows 10 compatible to give user full access to method editor and sequence table.

Built-in Leak Check

The automated leak check assures the system is air-tight before proceeding with the desorption of your sample.

Optical Sensor

The optical sensor detects the status of the TD tube on every step, both transporting to and from the heater oven.

Precision Robotic Arm

The robotic arm holds 1 mm X,Y,Z accuracy. The reliable gripping mechanism has the capability to handle both Pyrex glass and stainless steel tubes.

It features a hand-held controller for system maintenance and direct communication

CDS 9300 TD


It features a hand-held controller for system maintenance and direct communication.

It features a hand-held controller for system maintenance and direct communication.

Brochure

System description

With the highest programmable valve temperature on the market (350°C), the 9300 can venture into applications where other systems can not perform, including VOCs, sVOCs, polar and nonpolar compounds. The two stage trapping and desorption process with Pre-desorb and Pre-heat feature eliminate the need of any Peltier cooling or liquid cryogen to improve the resolution for early eluting molecules.ial analytical pyrolyzer (Model 100) in late 60s, and has been proudly making world's best pyrolyzers for over 50 years. Our products have evolved through 6 generations and represent the industries highest standard.

  • Versatile Configurations to Mainstream TD Tubes

  • Cryogen Free with Pre-Desorb and Pre-Heat

  • Hand-Held Plug-in Control Interface

  • High Temperature Valve Oven at max 350°C

  • Built Tough with Easy Maintenance

  • Powerful Windows Based Software

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Main Features

Cryogen Free with Pre-Desorb and Pre-Heat

To improve the resolution of early eluting molecules, CDS uses pre-desorb and pre-heat technique to mechanically confine analytes in the focus tube until the desorption temperature is reached.

Versatile Configurations to Mainstream TD Tubes

The CDS 9300 families could be configured to adopt 6m x 4.5" CDS TD tube, 10mm x 4.5" CDS TD tube, 1/4" x 3.5" PE and Markes TD tube, Tekmar 1/4" x 7" tube and VOST 16mm X 5" TD tube

Hand-Held Plug-in Control Interface

This hand-held interface gives you easy access to the Thermal Desorption system without using a PC. This is an essential feature for mobile labs in field sampling and analysis.

High Temperature Valve Oven at max 350°C

The high temperature oven (350°C) significantly extends the analyte range from VOCs to sVOCs.

Built Tough with Easy Maintenance

The CDS 9300 is built tough on military standard. Routine maintenance only requires basic tools in accessing the components.

Powerful Windows Based Software

The software is Windows 10 compatible to give user full access to method editor and sequence table

Adds a Mass Flow Controller (MFC) for near-real time sampling

CDS 9305 TD


Adds a Mass Flow Controller (MFC) for near-real time sampling

It features a hand-held controller for system maintenance and direct communication.

Brochure

System description

With the highest programmable valve temperature on the market (350°C), the 9300 can venture into applications where other systems can not perform, including VOCs, sVOCs, polar and nonpolar compounds. The two stage trapping and desorption process with Pre-desorb and Pre-heat feature eliminate the need of any Peltier cooling or liquid cryogen to improve the resolution for early eluting molecules.ial analytical pyrolyzer (Model 100) in late 60s, and has been proudly making world's best pyrolyzers for over 50 years. Our products have evolved through 6 generations and represent the industries highest standard.

  • Versatile Configurations to Mainstream TD Tubes

  • Cryogen Free with Pre-Desorb and Pre-Heat

  • Hand-Held Plug-in Control Interface

  • High Temperature Valve Oven at max 350°C

  • Built Tough with Easy Maintenance

  • Powerful Windows Based Software

  • ● Built-in MFC

  • ● Quick Connect to Vacuum

  • ● Compatible to Summa Canister

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Main Features

Cryogen Free with Pre-Desorb and Pre-Heat

To improve the resolution of early eluting molecules, CDS uses pre-desorb and pre-heat technique to mechanically confine analytes in the focus tube until the desorption temperature is reached.

Versatile Configurations to Mainstream TD Tubes

The CDS 9300 families could be configured to adopt 6m x 4.5" CDS TD tube, 10mm x 4.5" CDS TD tube, 1/4" x 3.5" PE and Markes TD tube, Tekmar 1/4" x 7" tube and VOST 16mm X 5" TD tube

Hand-Held Plug-in Control Interface

This hand-held interface gives you easy access to the Thermal Desorption system without using a PC. This is an essential feature for mobile labs in field sampling and analysis.

High Temperature Valve Oven at max 350°C

The high temperature oven (350°C) significantly extends the analyte range from VOCs to sVOCs.

Built Tough with Easy Maintenance

The CDS 9300 is built tough on military standard. Routine maintenance only requires basic tools in accessing the components.

Built-in MFC

With the built-in Mass Flow Controller, you could accurately control the sampling volume through the method editor

For continuous real time air monitoring

CDS 9350 TD


For continuous real time air monitoring

With a dual thermal desorption tube setup

Brochure

System description

With the highest programmable valve temperature on the market (350°C), the 9350 can venture into applications where other systems can not perform, including VOCs, sVOCs, polar and nonpolar compounds. The two stage trapping and desorption process with Pre-desorb and Pre-heat feature eliminate the need of any Peltier cooling or liquid cryogen to improve the resolution for early eluting molecules. An optional heated sampling line is available.

  • Versatile Configurations to Mainstream TD Tubes

  • Cryogen Free with Pre-Desorb and Pre-Heat

  • Hand-Held Plug-in Control Interface

  • High Temperature Valve Oven at max 350°C

  • Built Tough with Easy Maintenance

  • Powerful Windows Based Software

  • ● Dual TD Tubes

  • ● Low Thermal Mass Trap

  • ● Optional Heated Sampling Line

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Main Features

Cryogen Free with Pre-Desorb and Pre-Heat

To improve the resolution of early eluting molecules, CDS uses pre-desorb and pre-heat technique to mechanically confine analytes in the focus tube until the desorption temperature is reached.

Versatile Configurations to Mainstream TD Tubes

The CDS 9300 families could be configured to adopt 6m x 4.5" CDS TD tube, 10mm x 4.5" CDS TD tube, 1/4" x 3.5" PE and Markes TD tube, Tekmar 1/4" x 7" tube and VOST 16mm X 5" TD tube

Hand-Held Plug-in Control Interface

This hand-held interface gives you easy access to the Thermal Desorption system without using a PC. This is an essential feature for mobile labs in field sampling and analysis.

High Temperature Valve Oven at max 350°C

The high temperature oven (350°C) significantly extends the analyte range from VOCs to sVOCs.

Built Tough with Easy Maintenance

The CDS 9300 is built tough on military standard. Routine maintenance only requires basic tools in accessing the components.

Built-in MFC

With the built-in Mass Flow Controller, you could accurately control the sampling volume through the method editor

Dual TD Tubes

The 9350's thermal desorption chamber supports dual TD tubes for continuous sampling when one of the TD tube is desorbing.

Low Thermal Mass Trap

The 9350 features a standard 1/8" low thermal mass focus trap in its own desorption chamber for fast heating and cooling.

Optional Heated Sampling Line

This optional heated sampling line is handy when doing remote sampling.

The PAL RTC with Robotic Tool Change is the logical (r)evolution of the successful PAL-xt product line.

PAL RTC


Highest productivity

The PAL RTC with Robotic Tool Change is the logical (r)evolution of the successful PAL-xt product line.

Brochure

System description

Sample prep for chromatography is no longer  the bottleneck – automate your sample prep and sample injection - all on the PAL RTC.

The robotic change of tools enables unattended 24/7 operation, even for multistep workflows and thereby greatly increases the productivity of labs. At the same time process safety is optimized since all operations become traceable.

Automation is the way to increase productivity and (process) safety in the laboratory. Transferring repetitive or dangerous manual tasks to a robot improves safety. The possibility to run the instrument 24h/day increases throughput, especially for long sample preparations.

The PAL RTC was developed to maximize productivity in analytical and clinical labs. Robotic Tool Change (RTC) brings sample preparation to a higher level. Every process requires a number of different tools for best performance, e.g. a 10µL syringe for the accurate addition of small volumes followed by the dilution with a 1mL syringe. Robotic Tool Change allows to switch between different tools automatically.

This additional versatility in combination with the large number of available tools enable the design of tailored automation processes.

Learn more about the PAL RTC Benefits

  • ● Robotic Tool Change
  • ● Increased Vial Capacity
  • ● Minimized carryover
  • ● Process Safety
  • ● Discrimination free GC Injection
  • ● Efficient Mixing

Product Specialist

Dag Dacke

"Our expert in CTC PAL know-how and programming, and more than 20 years experience in the field of chromatography. Contact me if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
070-7319009

PAL RTC/RSI Benefits

Robotic Tool Change for productivity (PAL RTC only)

  • ● Automatic selection of the syringe with optimal accuracy for adding standards or preparing serial dilutions
  • ● On the fly switching between a syringe tool for the addition of an internal standard and the LC-MS Tool for subsequent Analysis
  • ● Possibility to permanently configure several workflows on one system for a walk-up prep station, e.g. Liquid/Liquid Extraction and Solid Phase Extraction (SPE)
  • ● Automated optimization of methods e.g. by selecting the most suitable Solid Phase Micro Extraction (SPME) fiber from an array of 4 different ones
  • ● Derivatization reactions performed without manual intervention for productivity, protection against hazardous chemicals and process safety
  • ● Automation of labor intensive manual workflows like protein digestion

Tool change

Increased Vial Capacity

  • ● 162 x 2mL or 60 x 10mL or 20mL vials/tray holder, other vial types and microtiter plates can be handled
  • ● With temperature controlled stacks a maximum of 9216 samples out of 24 MTP's can be handled
  • ● Cooled Stack with position control

Tool change

Minimized carryover and reproducible injection of minute sample volumes

Bottom sensing makes sure that small volumes can be injected out of a few µL of sample (e.g. 3 x 1 µL out of 5 µL).
With Constant Force Technology the PAL detects the correct position of the needle in the specially designed needle seal. Potential carryover is avoided.

Process Safety

Position detection means process safety. Missing vials or the correct position of the injector are detected and traced.Position detection means process safety. Missing vials or the correct position of the injector are detected and traced.
 

Position detection for the temperature controlled stack ensures that the drawer is in the correct position (open / closed) and the temperature is monitored.

Tool change

Discrimination free GC Injection

Ultrafast injections down to 100ms reduce discrimination in GC down to C40/C20 > 0.98.

Tool change

Efficient Mixing

For the efficient mixing during liquid homogenization and extraction steps
  • Magnetic transport of vials
  • Standard vial sizes: 2mL / 10mL / 20mL
  • One additional slot for custom vials
  • Provides efficient 2-phase mixing

Tool change

The PAL RSI is the robust workhorse for analytical labs.

PAL RSI


Workhorse for analytical labs

The PAL RSI is the robust workhorse for analytical labs. It is the cost effective solution for labs in need of robustness and uncompromising performance.

Brochure

System description

Scientists and technicians work under time pressure and often with a tremendous workload. The reliability of hardware and software should not be something the user has to worry about. Reliability is just expected from every tool.
That is exactly what the PAL RSI is designed for. It is a tool that you can rely on. More than 40.000 PAL systems worldwide are proof of this. Every PAL RSI leaving our factory has passed a thorough robustness test.
The PAL RSI is a flexible tool. Its open and modular architecture makes it the most versatile system on the market. Tools can be exchanged readily within minutes.
PAL customers working with GC love the possibility to use liquid, headspace or SPME sampling on the same system. LC customers appreciate the PAL because of its huge sample capacity, the range of syringes and valves available.
The PAL RSI is a safe investment: if your requirements grow additions of modules or even an upgrade to the full RTC functionality are possible at any time and give access to complete workflow automation.
  • ● Manual Tool Change
  • ● Increased Vial Capacity
  • ● Minimized carryover
  • ● Process Safety
  • ● Discrimination free GC Injection
  • ● Efficient Mixing

Product Specialist

Dag Dacke

"Our expert in CTC PAL know-how and programming, and more than 20 years experience in the field of chromatography. Contact me if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
070-7319009

PAL RTC/RSI Benefits

Tool change can be made manually on RSI

Increased Vial Capacity

  • ● 162 x 2mL or 60 x 10mL or 20mL vials/tray holder, other vial types and microtiter plates can be handled
  • ● With temperature controlled stacks a maximum of 9216 samples out of 24 MTP's can be handled
  • ● Cooled Stack with position control

Tool change

Minimized carryover and reproducible injection of minute sample volumes

Bottom sensing makes sure that small volumes can be injected out of a few µL of sample (e.g. 3 x 1 µL out of 5 µL).
With Constant Force Technology the PAL detects the correct position of the needle in the specially designed needle seal. Potential carryover is avoided.

Process Safety

Position detection means process safety. Missing vials or the correct position of the injector are detected and traced.Position detection means process safety. Missing vials or the correct position of the injector are detected and traced.
 

Position detection for the temperature controlled stack ensures that the drawer is in the correct position (open / closed) and the temperature is monitored.

Tool change

Discrimination free GC Injection

Ultrafast injections down to 100ms reduce discrimination in GC down to C40/C20 > 0.98.

Tool change

Efficient Mixing

For the efficient mixing during liquid homogenization and extraction steps
  • Magnetic transport of vials
  • Standard vial sizes: 2mL / 10mL / 20mL
  • One additional slot for custom vials
  • Provides efficient 2-phase mixing

Tool change

Robust and reliable sample handling.

PAL LSI


Robust and reliable sample handling

Reproducible results thanks to optimized injection handling

Brochure

System description

Only perfect injection handling gives reproducible results. The PAL LSI is designed for the precise and accurate handling of liquid samples of up to 100 μL in volume. In combination with the PAL Sample Control software all parameters of aspirating and dispensing of liquid samples can be fully controlled. This is crucial for perfect injections. A range of syringes from 1.2 μL to 100 μL is available. In the example highlighted beside an aliquot of an internal standard is sandwiched between transport solvent and the sample. Air gaps in between the liquids preclude mixing of the different liquids. The accurate control of these steps is the basis of reproducible methods.

The PAL LSI is a robot that can reach any three dimensional position within its working space and is ideally suited to pick and place objects like vials. It can inject from several sample containers into different detectors or transport vials from a tray to a temperature controlled stack.
  • ● Large Sample Capacity
  • ● Process Safety
  • ● Ultrafast Injections

Product Specialist

Dag Dacke

"Our expert in CTC PAL know-how and programming, and more than 20 years experience in the field of chromatography. Contact me if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
070-7319009

PAL LSI Benefits

Large Sample Capacity

The PAL LSI is a robot that can reach any three dimensional position within its working space and is ideally suited to pick and place objects like vials. It can inject from several sample containers into different detectors or transport vials from a tray to a temperature controlled stack.

Tool change

Process Safety

Proprietary drive technology enables the detection of missing vials and the correct position of the syringe needle in the injector port. Bending of syringe needles is excluded.

Tool change

Ultrafast injections

Injections down to 100 ms reduce discrimination in GC down to C40/C20 > 0.98.

Tool change

To maximize productivity the PAL DHR performs tasks with two heads in parallel.

PAL DHR Dual Head


Productivity x 2

Time is money. To maximize productivity the PAL DHR performs tasks with two heads in parallel

Brochure

System description

Two heads can move independently.

The heads can execute two independent workflows:
- Headspace with sample preparation, e.g. standard addition or derivatization
- High throughput parallel injections into two GC- or LC-systems

- The software optimizes the timetable to maximize productivity
-Automatic collision control ensures process safety and easy programming
-120 or 160 cm wide working area
-Combinations of RTC/RSI heads
-With an RTC head toolchange expands the options further
  • ● Robotic Tool Change
  • ● Increased Vial Capacity
  • ● Minimized carryover
  • ● Process Safety
  • ● Discrimination free GC Injection
  • ● Efficient Mixing

Product Specialist

Dag Dacke

"Our expert in CTC PAL know-how and programming, and more than 20 years experience in the field of chromatography. Contact me if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
070-7319009

PAL RTC/RSI Benefits

Robotic Tool Change for productivity (PAL RTC only)

  • ● Automatic selection of the syringe with optimal accuracy for adding standards or preparing serial dilutions
  • ● On the fly switching between a syringe tool for the addition of an internal standard and the LC-MS Tool for subsequent Analysis
  • ● Possibility to permanently configure several workflows on one system for a walk-up prep station, e.g. Liquid/Liquid Extraction and Solid Phase Extraction (SPE)
  • ● Automated optimization of methods e.g. by selecting the most suitable Solid Phase Micro Extraction (SPME) fiber from an array of 4 different ones
  • ● Derivatization reactions performed without manual intervention for productivity, protection against hazardous chemicals and process safety
  • ● Automation of labor intensive manual workflows like protein digestion

Tool change

Increased Vial Capacity

  • ● 162 x 2mL or 60 x 10mL or 20mL vials/tray holder, other vial types and microtiter plates can be handled
  • ● With temperature controlled stacks a maximum of 9216 samples out of 24 MTP's can be handled
  • ● Cooled Stack with position control

Tool change

Minimized carryover and reproducible injection of minute sample volumes

Bottom sensing makes sure that small volumes can be injected out of a few µL of sample (e.g. 3 x 1 µL out of 5 µL).
With Constant Force Technology the PAL detects the correct position of the needle in the specially designed needle seal. Potential carryover is avoided.

Process Safety

Position detection means process safety. Missing vials or the correct position of the injector are detected and traced.Position detection means process safety. Missing vials or the correct position of the injector are detected and traced.
 

Position detection for the temperature controlled stack ensures that the drawer is in the correct position (open / closed) and the temperature is monitored.

Tool change

Discrimination free GC Injection

Ultrafast injections down to 100ms reduce discrimination in GC down to C40/C20 > 0.98.

Tool change

Efficient Mixing

For the efficient mixing during liquid homogenization and extraction steps
  • Magnetic transport of vials
  • Standard vial sizes: 2mL / 10mL / 20mL
  • One additional slot for custom vials
  • Provides efficient 2-phase mixing

Tool change

Addittional modules for automation of different tasks.

PAL RTC/RSI/LSI Modules


Addittional modules for automation of different tasks

Product Specialist

Dag Dacke

"Our expert in CTC PAL know-how and programming, and more than 20 years experience in the field of chromatography. Contact me if you have questions or need a quotation"

070-7319009
This email address is being protected from spambots. You need JavaScript enabled to view it.

Agitator Module


Barcode Reader Module

This Barcode Reader Module reads the barcode labels on 2mL, 10mL and 20mL vials regardless of the orientation on the vials. Therefore it ensures highest process safety and traceability


Reads horizontal 1 D barcodes


Two scanners allow identification of vials irrespective of position of the barcode


Works with 2mL, 10mL and 20mL vials


Centrifuges

For the efficient centrifugation in automated workflows (e.g. protein precipitation, phase separation)


Relative centrifugal force: 

2000 x g with Centrifuge Combi 
5000 x g with Centrifuge 2 mL


Vial format:

Centrifuge Combi: 2 mL (6 vials) + 
                          10 mL / 20 mL (2 vials)
Centrifuge:           2 mL (8 vials)


See the Centrifuges Module brochure 


Decapper

Opens/closes 2, 10, 20 mL screw cap vials without any change of hardware (no adapters required)


A defined torque guarantees the reproducible and leak-tight closing of headspace vials


PAL Re-Cap vials ensure consistent performance for multiple open/close cycles


See the DeCapper Module brochure 


Dilutor

For efficient and accurate addition of larger amounts of liquids

100µL, 1mL (standard), 5mL & 10mL dispensing syringes available


Optional selector valves allow dispensing of up to 5 different liquids


 Application notes availible


Fast Wash Module

Cleans syringes of  gauges  19 to 26


Integrated pumps for active wash solvent delivery


Supports two different wash solvents (e.g. aqueous and organic)


Reduced wash solvent consumption by automatic flow adjustments


Can be mounted underneath Valve Drives to minimize required space


Large Wash and Solvent Module

Wash Module for large volume injections


2x 100mL solvent vials


Waste port with connector for waste bottle


Heatex Stirrer Module

For powerful mixing and heating in sample prep and SPME Arrow


Temperature range 30° - 150°C


Stirring speed up to 1600 rpm (200 cycloidal loops)


Optimized for 20mL vials (for 10 mL vials special adapters are required)


SPME Arrow Fiber Conditioning

For the conditioning of SPME Arrow and SPME fibers prior to sample enrichment, max. 350°C


Position for automated conditioning


Position for manual pre-conditioning


Automated purge gas valve


Manual gas valve for pre-conditioning


Replacement liners for easy maintenance


Standard Wash Station

Wash Module for low volume injections


4x 10mL wash solvent vials


1x 10mL waste vial


Optional waste port  to connect a waste bottle


Peltier Stack 2DW Module

For the storage of two racks or plates under defined temperature conditions between 4°C and 40°C. Allows to use transparent standard vials with light sensitive compounds. A maximum of four Peltier Stacks can be configured on a PAL with extended x-axis length.

Capacity:

  • 2x MTP (Multi Titer Plate)
  • or 2x DW (Deep Well Plate)
  • or 2x VT15 (15 x 10mL)
  • or 2x VT54 (54 x 2mL) 
  • or 2x VT70 (70 x 1mL) 
  • or combinations

Peltier Stack 6DW Module

For the storage of six racks or plates under defined temperature conditions between 4°C and 40°C. Allows to use transparent standard vials with light sensitive compounds. A maximum of four Peltier Stacks can be configured on a PAL with extended x-axis length.

Capacity:

  • 6x MTP (Multi Titer Plate)
  • or 6x DW (Deep Well Plate)
  • or 6x VT15 (15 x 10mL)
  • or 6x VT54 (54 x 2mL)
  • or 6x VT70 (70 x 1mL)
  • or combinations

Stack 6DW /12MT Module

For the storage of racks or plates at room temperature. Allows to store samples with light sensitive compounds. A maximum of four Stacks can be configured on a PAL with extended x-axis length.

Capacity 6DW:

  • 6x MTP (Multi Titer Plate)
  • or 6x DW (Deep Well Plate)
  • or 6x VT15 (15 x 10mL)
  • or 6x VT54 (54 x 2mL)
  • or 6x VT70 (70 x 1mL)
  • or combinations

Capacity 12MT:

  • 12x MTP (Multi Titer Plate, shallow well)

Trayholder

The Trayholder offers sample storage at room temperature. A PAL with extended x-axis length can hold up to 7 Trayholders.

Capacity:

  • 3x MTP (Multi Titer Plate)
  • or 3x DW (Deep Well Plate)
  • or 3x VT15 (15 x 10/20mL
  • or 3x VT54 (54 x 2mL)
  • or 3x VT70 (70 x 1mL)
  • or combinations
  • or 60x 10/20mL (with one R60 tray)

Valve Drive Module

Universal Valve Drive Module for sample injection, column switiching for online LC-LC-MS or online SPE-LC-MS, multiplexing, column selection and many more.

The Valve Drive Module supports VICI/Valco and Rheodyne valve types.


Injection port bottom sensing minimizing carryover


Constant Force Technology to reduce dead volume during injection process


UHPLC/HPLC: up to 50% faster switching times for optimum system performance and prolonged column life time


Stackable design to reduce the space demand and allow any flexible configuration


Huge flexibility to arrange multiple valve solutions


The Fast Wash Module is also stackable below a Valve Drive


Vortex Mixer Module

For efficient mixing during liquid homogenization and extraction steps.

Magnetic transportation


Standard vial sizes: 2mL / 10mL / 20mL


One additional slot for custom size vials


Provides very efficient mixing

Tools that can be automatically changed during run on RTC and manually on RSI

PAL RTC/RSI Tools


Tools that can be automatically changed during run on RTC and manually on RSI

Product Specialist

Dag Dacke

"Our expert in CTC PAL know-how and programming, and more than 20 years experience in the field of chromatography. Contact me if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
070-7319009

Liquid Syringe Tools

The right syringe for every application

Supports 57mm or 85mm syringe needle lengths


Syringes available: 1.2µL / 5µL / 10µL /100µL / 250µL / 500µL / 1'000µL / 10'000µL


For a detailed overview click on RTC Syringe Tools


Headspace Tools

Three different syringe volumes: 1'000µL / 2'500µL / 5'000µL


Syringe temp. 40°C up to 150°C in 1°C steps


Syringe flush with inert gas flow through X-Y-Z rail


Magnetic vial transport for 2mL, 10mL and 20mL vials


For a detailed overview click on RTC Syringe Tools


SPME Arrow Tool

The tool to increase productivity in SPME

 
Holder for all PAL SPME Arrows 1.1 or 1.5mm


Max. penetration depth 70mm


Easy exchange of SPME Arrow by hand


Best conditioning is achieved with the SPME Arrow Conditioning Module


Application notes: Determination of iodoform in drinking water by SPME and GC-MS   and Determination of C2-C12 aldehydes by SPME on-fiber derivatization and GC-MS


SPME Tool

The tool for fully automatic SPME sampling

New SPME holder for increased fiber protection


Compatible with a variety of SPME fibers


Easy fiber exchange by hand


For 10mm or 20mm fiber length


ITEX Dynamic Headspace Tool

Powerful sample enrichment for GC

Rapid and sensitive enrichment of volatile and semi-volatile compounds from solid, liquid and gaseous samples


A choice of different adsorbents for best sensitivities


No sample loops, transfer lines or valves, no contamination issues


PAL Robotic Tool Changes enables head space, SPME and ITEX-sampling within one sequence


Watch ITEX Dynamic Tool Videoor see ITEX brochure

ITEX method development: an open access articlefrom Laaks et al. is available.


LC-MS Tool

Rapid injection cycles with minimized carryover 



The special design minimizes carryover even for the most sensitive detectors


Enables special injection techniques like sandwiching a sample between air gaps for accurate small volume injections


Flow control guarantees bubble-free solvent delivery


Position detection for zero dead volume positioning of syringe needle in the injector port


Watch LC-MS Tool Video


Dilutor Tool

For efficient and accurate addition of larger amounts of liquids

100µL, 1mL (standard), 5mL & 10mL dispensing syringes available


Optional selector valves allow dispensing of up to 5 different liquids


 Application notes availible


Pipette Tool

Essential for Life Science, Clinical  & Chemical Applications

Tool for 200 µL & Tool for 1000 µL tips


Single or Multi Dispense


Only the PAL RTC can combine Pipette Tools and glass syringes on one System


PAL Pipette Tips and Racks ensure consistent Performance


See the Pipette Tool brochure

Smart Syringes, SPME-fibers and more

PAL Consumables


Smart Syringes

Stay in contact with your Smart Syringes!

Brochure

SPME Arrow

Higher productivity and longer lifetime for SPME

SPME Fibers

Optimized for automation

Vials and Caps

PAL System approved

Stay in contact with your Smart Syringes

AL Smart Syringe features electronic data storage for highest precision and process safety. Each Smart Syringe is equipped with its own read/write chip with preset parameters, ranges and usage tracking. 
The PAL Smart Syringe is an integral part of the superior quality of every PAL System.
  • Guaranteed Quality: The consistent Quality of each syringe is guaranteed by CTC Analytics.
  • Increased Process Safety: The syringe design is tailor-made for use with the PAL System - approved and validated by CTC Analytics.
  • Ease of Use: The syringe is automatically recognized by the PAL System and all important parameters are automatically loaded - for a simple, fast, and errorfree setup.
  • ● Identification/Recognition: Every syringe can be traced over its complete lifetime by means of its  own specific ID.
  • ● Traceable Syringe History: The total number of strokes, temperatures, date of first use and other information can be stored on the chip of every PAL Smart Syringe. Warnings for preventive maintenance can be configured.
  • ●  Color Code for Easy Identification of the Syringe Type: Each syringe head is colored according to the color code printed on every CTC syringe package.

Product Specialist

Dag Dacke

"Our expert in CTC PAL know-how and programming, and more than 20 years experience in the field of chromatography. Contact me if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
070-7319009

PAL SPME Arrows: Higher productivity and longer lifetime for SPME

SPME has become one of the most widely used extraction technologies for environmental, food and clinical analyses. It is well suited for automated sample preparation resulting in reduced time per sample, less sample manipulation and solvent consumption. However, the technology remained almost unchanged with some significant drawbacks, such as the limited mechanical stability and small phase volumes of the fibers.

The PAL SPME Arrow (patent pending) is a new technology for microextraction, combining trace level sensitivity (up to 10x higher) with high mechanical robustness (at least 2x longer lifetime). The PAL SPME Arrow has an outer diameter of 1.1 or 1.5mm, resulting in large sorption phase surfaces and volumes. The arrow-shaped tip allows smooth penetration of vial and injector septa. In contrast to traditional SPME fibers, the Arrow design fully protects the sorptive material, minimizing adverse influences and loss of analytes during transfer processes. With the PAL RTC and RSI the SPME Arrow sampling is fully automated leading to high productivity. The PAL Heatex Mixer Module optimizes performance for headspace and especially immersion extraction.

SPME Arrow Datasheet

PAL SPME Fibers: Optimized for automation

Since its introduction by Pawliszyn et al. (ref. 1) Solid Phase Micro Extraction (SPME) has seen a tremendous development. SPME is a very effective way of automated sample preparation. It is used for extracting organics from a matrix (solid, liquid or gaseous) into a stationary phase immobilized on a fiber. The analytes are thermally desorbed directly in the injector of a gas chromatograph. Originally mostly used for extracting solvents with excellent sensitivities from aqueous matrices the range of applications today spans from chemical and environmental to medical applications.

PAL SPME Fibers have been developed and optimized for the most successful SPME sampler, the PAL System Autosampler. The fibers are offered with different coatings and film thicknesses (PAL SPME Fiber brochure). Their excellent extraction properties have been demonstrated for important applications and are compared to fibers available in the market (PAL SPME Fiber Comparison).

PAL SPME Broschure

PAL System Vials & Vial Caps

  • Designed for our new PAL3-Decapper Tool
  • Designed for our new PAL3-Decapper Tool
  • Better sealing due to flat finish of contact surface to septum
  • Easy access to last drops due to slightly curved inner bottom shape
  • PAL System tested and approved 


for more detailed Information see our PAL Systems Vials & Vial Caps Flyer

Vials & Vial Caps Flyer

Easy to use routine software

PAL Sample Control (PAL RTC/RSI /LSI and DHR)


Easy to use routine software

PAL Sample Control software is the user-friendly tool for the daily routine jobs. With a few clicks sample lists are generated or imported. Now PAL Sample Control starts the operation and the data acquisition. Since PAL Sample Control Interfaces seamlessly with most of the major chromatographic or MS data systems only one sample list has to be handled. Different user levels ensure process safety.
Creation or import of sample lists is done with a few clicks. With one more click sample preparation and data acquisition are started.

Productivity

PAL Sample Control allows overlapping of time consuming steps. It optimizes automatically the timing of various steps in a sample preparation process and generates a schedule that minimizes the runtimes of sequences. This increases sample throughput greatly and boosts productivity.

PAL Sample Control optimizes productivity by overlapping individual steps. In many cases runtimes of sequences can be cut to 1/3 or less compared to a sequential procedure.

Powerful Method Editor

While PAL Sample Control is straightforward to use in the daily operations it is also a powerful tool for the generation of tailored methods. A set of tested methods that come with every system (e.g. headspace injection, partial loop liquid injection etc.) can be used as templates and optimized or tailored for specific workflows. Furthermore a large number of building blocks (tasks) for method development are part of the software. These building blocks make it easy to generate new methods, even for complex workflows.

A powerful yet easy to use tool to generate custom methods is included.

Supported CDS and MS-Data Systems

  • Analyst
  • ChemStation LC/GC/MSD
  • Chromcard
  • ChromPerfect
  • ChromQuest
  • Clarity
  • Empower 2EZ
  • ChromMassHunter for GC/MS & LC/MS
  • Master Lab
  • MassLynx
  • MS Workstation
  • QuanLab
  • Xcalibur

Fully Automated Sample Preparation instrument for rapid extraction of solid dose forms, gels, and liquids.

The CambTEK Rapid Extraction System (RES)


RES-CG and RES-Sonics: Fully Automated Sample Preparation instrument for rapid extraction of solid dose forms, gels, and liquids.

The RES uses patented turbulent flow technology, with optional ultasonication or crush and grind mechanical force to accelerate sample preparation extractions.

Video Presentation

Brochure

Fully automated and aqurate sample preparation

Samples are quickly extracted, filtered, and diluted, ahead of analysis. The RES is suitable for testing content uniformity (CU), impurity (imps), composite and bulk assay, ICH stability assay, blend and granulation uniformity, and other applications requiring a liquid extracted sample preparation. From analytical R&D through to QA/QC laboratories, the RES improves quality of data, productivity, compliance, process standardization, and simplicity, whilst also delivering health & safety, environmental, and economic benefits.
  • ● Full automation of all steps from formulation to diluted and filtered samples in 2 ml vials
  • ● Gravemetric confirmation of all solvent dispensed volumes by build in balances
  • ● Full tracability via barcode on all used consumables
  • ● Unbeatable reproducability independent of system user

Product Specialist

Mats Grapne

"More than 30 years experience in the field of HPLC, Spectroscopy and other analytical equipments. Contact me if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
08-473 3340

Ease of use

Step one:
Load the sample into the FlowCell

Step four:
Load the puck onto the Carosel

 

Step two:
Load the FlowCell into the Puck

Step five:
Process the sample

 

Step three:
Scan the barcode and input the data

Step six:
Result out

res on1

RES Technology

The selected extraction eluent is dispensed to ASTM Class A dispensing accuracy, with gravimetric verification of solvent arrival. The extraction eluent is then circulated around the closed loop system, the turbulent flow quickly extracting the sample contained within the FlowCell.The selected extraction eluent is dispensed to ASTM Class A dispensing accuracy, with gravimetric verification of solvent arrival. The extraction eluent is then circulated around the closed loop system, the turbulent flow quickly extracting the sample contained within the FlowCell.


An aliquot of solute is filtered and dispensed into a septa-sealed 22 mL primary vial. If required, the filtrate is then automatically diluted to ASTM Class A dispensing accuracy, to achieve the required concentration from 1:1 to 1:100000 dilution range.


After mixing to achieve homogeneity, a volume can be automatically dispensed into a septa-sealed 2 mL HPLC vial, or directly injected into your analyser.

 

  • Quality control

    Designed to highest standards to ensure regulatory and quality compliance of data integrity, validity, and repeatability.
  • Productivity

    The unique SPEx technologies, Forced Jet Mixing and High Frequency Pulverizing, in conjunction with the extraction pouch, simplify and speedup laboratory productivity
  • Reproducible Processes

    Semi automated sample preparation for improved repeatability over traditional manual techniques
  • Health & Safety

    Semi automated sample preparation and enclosed system reduces user exposure to harmful substances
  • Process Standardization

    Platform technology aids compliance and consistent results independent of user proficiency or laboratory location
  • Versatility

    Processes a wide range of sample types in both single sample and bulk assay, including more challenging formulations such HPMC, PEG, PEO and laser-drilled.
  • Flexibility

    provides sample preparation front-end to any dosage form analytical workflow
  • Economic

    Increased productivity, no washing, no glassware, affordable technology, significantly reduce sample preparation costs
  • Ease of Use

    Intuitive instrument and software use, and error prevention with barcoded consumables
  • Reliability

    Robust design and high component specification delivers minimal downtime and maximum reliability.

RES Consumables

The patented technology and features of the FlowCell aid rapid extraction. The labyrinth acts as an effective powder trap, allowing powders, gels and semi-solids to be constrained without loss prior to testing. The optional RES ‘Flowtainer’ insert allows liquids and low-viscosity gels to be processed within the same workflow.

The consumable workflow and sanitary design minimizes cleaning requirements.

11 types of Millipore filters are available, with an extensive selection of pre-filters, pore sizes, and membrane materials, suitable for a wide range of applications.
Included are two borosilicate Chromacol vials, manufactured to meet international standards.

All components carry a barcode to uniquely identify the consumable ‘family’, which allows for sample tracking, instrument method and safety error-checking, and ultimately greater compliance. After the sample has been prepared, any of the barcodes from that particular family can be scanned to access the related post-extraction sample report.

Consumable pack contents

● 1 × FlowCell: Barcoded 9 cm3 or 14 cm3 sample capacity. Patented technology for accelerated extraction.

● 1 × 20 mL vial: Barcoded primary sample vial for collection of filtrate and dilution. Screw cap & septa.

● 1 × 2 mL vial: Barcoded amber HPLC vial, crimp top & septa.

● 1 × Filter: Choice of barcoded filter - see below for the full selection.

The miVac DNA is an ideal small vacuum concentrator for the molecular biology laboratory.

miVac DNA


All included in a compact format

The miVac DNA is an ideal small vacuum concentrator for the molecular biology laboratory.

Racks and Accessories

Brochure

System description

The miVac DNA is capable of removing low volumes of water and organic solvents from a variety of sample formats including tubes, microplates, vials and round bottom flasks. Making it an ideal concentrator for the busy molecular biology laboratory.

Key Features:

Built in high performance vacuum pump, Concentration chamber with electro-magnetic drive for quiet, maintenance free operation, Fixed angle aluminium rotor for 1.5 ml or 2 ml micro-centrifuge tubes, High displacement vacuum pump, Clear, acrylic lid to monitor progress
  • Simply position the system on the bench, connect the power lead and exhaust tube and look forward to faster, trouble-free concentration!
  • ● Concentration time and temperature are readily monitored on the large clear display
  • ● Parameter scan be easily set and selected using the friendly dial
  • ● Optimise concentration time
  • ● Faster than any other system in its class.

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Application Examples

Clinical and Diagnostic Testing

Evaporative sample preparation for forensic and diagnostic clinical tests must be performed scrupulously. Genevac systems are used by clinical biochemists and forensic scientists for a number of testing methodologies, such as vitamin D or K analysis, neonatal screening and forensic toxicology.

Mass Spectrometry (MS) is replacing radio-immunoassay (RIA) in Clinical biochemistry analysis, removing the need to use radioactive reagents. One of the Steroid assays performed by hospital clinical labs is for Vitamin D analysis where there is a need to identify the relative abundance of vitamin D2 and D3. Samples are typically extracted into Hexane, concentrated (e.g. using a miVac) and analysed by MS (avoiding ion suppression problems often seen with RIA).

Clinical and forensic toxicology investigations also utilise MS methodology, typically with solid phase extraction and evaporation as part of the sample preparation process. Blood and urine analysis can be utilised as part of a medico-legal investigation into drug-related deaths and drug-facilitated crimes and in the clinical assessment of alcohol/drug consumption. Hair analysis can also provide evidence over time of drug or alcohol abuse, as part of programme compliance for those participating in drug or alcohol dependency treatment or for workplace or health insurance screening. The EZ-2 has been used to streamline the sample preparation process whilst maintaining sample integrity and improving sensitivity.

Tandem MS is also used to identify metabolic disorders which include aminoacidemias, urea cycle disorders, organic acidurias, and fatty acid oxidation disorders. Samples can be presented as plasma, urine, and blood spots or urine on filter paper. Sample preparation techniques can include solvent extraction, acid derivitisation and evaporation prior to reconstitution in a suitable medium for injection to MS. Evaporation of butanolic HCl used for derivatisation using blowdown techniques results in corrosion of the system especially pins/needles/jets which can lead to contamination of samples and erroneous results. The EZ-2 with HCI resistance commonly used for these sample preparation stages. One example would be the test for CAT (carnitine acyl carnitine translocase deficiency) in neonates, an inborn error of metabolism. Lack of this enzyme prevents the body from converting fats into energy. Labs do the initial test on Guthrie cards (dried blood spots). The cards are punched and extracted with 200ul of Methanol. The supernatant is placed into microtitre plates and dried. Samples are then derivatised using approx 100ul 3N HCl in anhydrous Butanol and dried again. Finally, samples are re-suspended in Water & acetonitrile for analysis by MS.

miVac concentrators have been used by the Australian Sports Drug Testing Laboratory to improve the testing for synthetic insulin analogues in athletes' blood samples. Using the miVac's ability to control conditions during the concentration step the analyst has more confidence that they are seeing the true blood concentration of potential drugs of abuse in the athlete's sample.


Useful Papers:

  • Evaluation of the EZ-2 for Forensic Toxicology - Dr Eleanor Miller & Dr Simon Elliott, ROAR Forensics, UK. Evaluated the EZ-2 for use concentrating extracts from hair samples to detect alcohol and drugs of abuse metabolites entrained in the samples
  • Evaluation of Evaporative Sample Preparation Techniques for the Extraction of Drugs of Abuse from Urine. Describes the development of a new method for the pre- analytical extraction of drugs of abuse from urine samples pertaining to drug facilitated sexual assault cases. By Forensic Science Ireland (FSI).
  • Better Detection of Insulin Analogues - Great care is required when preparing the samples for analysis, this paper evaluates two possible methods (nitrogen blow down & vacuum concentration) and highlights the pitfalls. Study by Australian Sports Drug Testing Laboratory.

Contact us if you are interested in any of the above papers

DNA & Oligonucleotides

Genevac systems facilitate a wide range of DNA sample preparation and processing activities, ranging from straightforward small volume concentration of DNA pellets prior to PCR, through to high throughput processing of many purified DNA or oligonucleotide samples.  Where a dry sample of DNA is required, concentration to dryness in a centrifugal evaporator is the ideal method, presenting the DNA as a dry film in the tube of plate well.  Freeze drying of DNA samples is not recommended because the resultant DNA powder is easily blown about or moved by electrostatic charges.

DNA Concentration
Concentration of DNA from samples containing water or a mixture of water and alcohols is a simple process, which for most researchers requires the miVac DNA concentrator.  Concentration to remove a few hundred microlitres of alcohol from a DNA pellet takes approximately 10 minutes, or less.   This is one of the simplest applications of a Genevac system – in a miVac DNA concentrator, set the temperature, select the method for alcohols or water, and press start. 

Oligonucleotides & DNA Purification
The manufacture of oligonucleotides commonly has two steps where evaporation is required, evaporation of ammonia solutions following synthesis, and then subsequent evaporation of purified samples.   Protection of oligonucleotides from damage during drying is critical, especially where a tag or label has been attached to the DNA.  Two studies by Genevac users show that this can safely be achieved in a Genevac evaporator: 
  • Comparing Evaporators for Drying Oligonucleotides - Catherine McKeen, Eurogentec SA A Rapid,
  • Safe Technique for Drying Oligonucleotides - Dr Tim Watts, Wellcome Trust Human Genome Centre
Samples containing ammonia solution should be evaporated using Dri-Pure® (500g) to prevent sample loss and cross contamination.  When ammonia solution is subjected to a vacuum the ammonia degasses.  Degassing must be controlled or the resultant foam overflows the tube causing sample loss and cross contamination.  In the same way that you control degassing of a bottle of soda by opening it slowly, gentle application of vacuum is required, this coupled with the high rotors speeds of Dri-Pure keep every sample where it should be.  The latest versions of the EZ-2 come with such a method pre-programmed, and the method is simple to program on the HT-Series.
  
Where samples have been purified by reverse phase HPLC samples are presented in a mixture of water and methanol or acetonitrile.  The methods laid out in the Post Purification Sample Handling section should be followed.  The imbalance tolerance built into Genevac systems gives researchers confidence that eluates at different ends of the gradient will still dry down, and if there is too much imbalance the system will automatically shut down and tell the user.

Preparation of DNA Microarrays
For certain microarraying techniques concentrated samples of DNA are required.  To maintain such a concentration is difficult due to the volatile nature of the buffers holding the DNA, therefore samples should be made up to the required volume immediately prior to analysis.  A study by the Wellcome Trust Centre for Human Genetics in Oxford has shown that when an EZ-2 is used in this process the data quality returned by the system is significantly better, reducing the no call rate by 80% or more.

Modular range of centrifugal vacuum concentrators.

miVac Sample Concentrators


Modular range of centrifugal vacuum concentrators

miVac is a modular range of centrifugal vacuum concentrators and freeze driers capable of removing water and organic solvents from a variety of sample formats including tubes, microplates, and vials.

Racks and Accessories

Brochure

System description

Choose from the Duo Concentrator for low sample numbers or the Quattro Sample Concentrator for larger numbers. Combine with a Duo, Quattro or Scroll vacuum pump depending on the solvents being concentrated and add further options such as the unique SpeedTrap cold trap and vacuum controller.

Unique solid aluminium JetRotors and built-in special methods optimise the concentration of water and water mixtures, improving performance and reducing time.

The miVac SpeedTrap™ may also be used for freeze drying low volumes of water, and can be operated as a stand alone small volume freeze drier, or configured as a combined concentration / freeze drying workstation
  • ● Compact modular units
  • ● Easy to use
  • ● Precise temperature control
  • ● Heat & run timers
  • ● Novel frost free SpeedTrap
  • ● Unique solid aluminium rotors
  • ● Fast evaporation
  • ● Environmentally friendly

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Application Examples

Clinical and Diagnostic Testing

Evaporative sample preparation for forensic and diagnostic clinical tests must be performed scrupulously. Genevac systems are used by clinical biochemists and forensic scientists for a number of testing methodologies, such as vitamin D or K analysis, neonatal screening and forensic toxicology.

Mass Spectrometry (MS) is replacing radio-immunoassay (RIA) in Clinical biochemistry analysis, removing the need to use radioactive reagents. One of the Steroid assays performed by hospital clinical labs is for Vitamin D analysis where there is a need to identify the relative abundance of vitamin D2 and D3. Samples are typically extracted into Hexane, concentrated (e.g. using a miVac) and analysed by MS (avoiding ion suppression problems often seen with RIA).

Clinical and forensic toxicology investigations also utilise MS methodology, typically with solid phase extraction and evaporation as part of the sample preparation process. Blood and urine analysis can be utilised as part of a medico-legal investigation into drug-related deaths and drug-facilitated crimes and in the clinical assessment of alcohol/drug consumption. Hair analysis can also provide evidence over time of drug or alcohol abuse, as part of programme compliance for those participating in drug or alcohol dependency treatment or for workplace or health insurance screening. The EZ-2 has been used to streamline the sample preparation process whilst maintaining sample integrity and improving sensitivity.

Tandem MS is also used to identify metabolic disorders which include aminoacidemias, urea cycle disorders, organic acidurias, and fatty acid oxidation disorders. Samples can be presented as plasma, urine, and blood spots or urine on filter paper. Sample preparation techniques can include solvent extraction, acid derivitisation and evaporation prior to reconstitution in a suitable medium for injection to MS. Evaporation of butanolic HCl used for derivatisation using blowdown techniques results in corrosion of the system especially pins/needles/jets which can lead to contamination of samples and erroneous results. The EZ-2 with HCI resistance commonly used for these sample preparation stages. One example would be the test for CAT (carnitine acyl carnitine translocase deficiency) in neonates, an inborn error of metabolism. Lack of this enzyme prevents the body from converting fats into energy. Labs do the initial test on Guthrie cards (dried blood spots). The cards are punched and extracted with 200ul of Methanol. The supernatant is placed into microtitre plates and dried. Samples are then derivatised using approx 100ul 3N HCl in anhydrous Butanol and dried again. Finally, samples are re-suspended in Water & acetonitrile for analysis by MS.

miVac concentrators have been used by the Australian Sports Drug Testing Laboratory to improve the testing for synthetic insulin analogues in athletes' blood samples. Using the miVac's ability to control conditions during the concentration step the analyst has more confidence that they are seeing the true blood concentration of potential drugs of abuse in the athlete's sample.


Useful Papers:

  • Evaluation of the EZ-2 for Forensic Toxicology - Dr Eleanor Miller & Dr Simon Elliott, ROAR Forensics, UK. Evaluated the EZ-2 for use concentrating extracts from hair samples to detect alcohol and drugs of abuse metabolites entrained in the samples
  • Evaluation of Evaporative Sample Preparation Techniques for the Extraction of Drugs of Abuse from Urine. Describes the development of a new method for the pre- analytical extraction of drugs of abuse from urine samples pertaining to drug facilitated sexual assault cases. By Forensic Science Ireland (FSI).
  • Better Detection of Insulin Analogues - Great care is required when preparing the samples for analysis, this paper evaluates two possible methods (nitrogen blow down & vacuum concentration) and highlights the pitfalls. Study by Australian Sports Drug Testing Laboratory.

Contact us if you are interested in any of the above papers

DNA & Oligonucleotides

Genevac systems facilitate a wide range of DNA sample preparation and processing activities, ranging from straightforward small volume concentration of DNA pellets prior to PCR, through to high throughput processing of many purified DNA or oligonucleotide samples.  Where a dry sample of DNA is required, concentration to dryness in a centrifugal evaporator is the ideal method, presenting the DNA as a dry film in the tube of plate well.  Freeze drying of DNA samples is not recommended because the resultant DNA powder is easily blown about or moved by electrostatic charges.

DNA Concentration
Concentration of DNA from samples containing water or a mixture of water and alcohols is a simple process, which for most researchers requires the miVac DNA concentrator.  Concentration to remove a few hundred microlitres of alcohol from a DNA pellet takes approximately 10 minutes, or less.   This is one of the simplest applications of a Genevac system – in a miVac DNA concentrator, set the temperature, select the method for alcohols or water, and press start. 

Oligonucleotides & DNA Purification
The manufacture of oligonucleotides commonly has two steps where evaporation is required, evaporation of ammonia solutions following synthesis, and then subsequent evaporation of purified samples.   Protection of oligonucleotides from damage during drying is critical, especially where a tag or label has been attached to the DNA.  Two studies by Genevac users show that this can safely be achieved in a Genevac evaporator: 
  • Comparing Evaporators for Drying Oligonucleotides - Catherine McKeen, Eurogentec SA A Rapid,
  • Safe Technique for Drying Oligonucleotides - Dr Tim Watts, Wellcome Trust Human Genome Centre
Samples containing ammonia solution should be evaporated using Dri-Pure® (500g) to prevent sample loss and cross contamination.  When ammonia solution is subjected to a vacuum the ammonia degasses.  Degassing must be controlled or the resultant foam overflows the tube causing sample loss and cross contamination.  In the same way that you control degassing of a bottle of soda by opening it slowly, gentle application of vacuum is required, this coupled with the high rotors speeds of Dri-Pure keep every sample where it should be.  The latest versions of the EZ-2 come with such a method pre-programmed, and the method is simple to program on the HT-Series.
  
Where samples have been purified by reverse phase HPLC samples are presented in a mixture of water and methanol or acetonitrile.  The methods laid out in the Post Purification Sample Handling section should be followed.  The imbalance tolerance built into Genevac systems gives researchers confidence that eluates at different ends of the gradient will still dry down, and if there is too much imbalance the system will automatically shut down and tell the user.

Preparation of DNA Microarrays
For certain microarraying techniques concentrated samples of DNA are required.  To maintain such a concentration is difficult due to the volatile nature of the buffers holding the DNA, therefore samples should be made up to the required volume immediately prior to analysis.  A study by the Wellcome Trust Centre for Human Genetics in Oxford has shown that when an EZ-2 is used in this process the data quality returned by the system is significantly better, reducing the no call rate by 80% or more.

Environmental Analysis

Monitoring of the environment for substances potentially harmful to health is a core activity not just for government departments but for many organisations who wish to ensure that they are not harming their staff or the environment.  Samples of air, water, soil or plant matter are routinely monitored for the presence of potentially harmful substances – for example, pesticides in river water or the soil. Foodstuffs are similarly monitored.

When testing the water quality of a river, a point sample only provides a snap-shot of the situation, where as monitoring over a period of time will help present a better overall picture and can indicate where there is chronic build-up of a potentially harmful substance(s).  Samples of tissue are often taken from fish living in the river are examined to determine the nature of any chemicals in the water.  Another more recent approach is to use a virtual fish, a semi-permeable membrane device (SPMD) developed by the US Geological Survey.  This is placed in the river for a period of time, and then any organic chemicals are extracted with solvent, concentrated and analysed as they would be from a fish.

Air quality can be monitored similarly by filtering air for a period of time, extracting the filter, and then concentrating and analysing whatever organic molecules may be trapped on the filter.  This is a key activity in industrial environments where PAHs may be a risk factor for workers.

When concentrating samples the EZ-2 (small volumes) and Rocket (large volumes) are ideal tools for concentrating in the analytical laboratory.  Coupled with SampleGenie they enhance analyte recovery, reduce inter-sample variability and free workers to do more productive tasks than monitoring a concentration system. SampleGenie enables large volume samples to be concentrated directly into an autosampler vial, eliminating the need to transfer the sample. 

Useful Papers:
Improving Analysis of Airborne PAHs
Detectionand Quantification of Algal Toxins in Surface Water
Analysis of Glyphosate and its degradation Products in Surface Water


Food & Beverage

Quality and safety testing of food and beverages is an area of growing importance, be that for exporters, importers or government bodies, accurate analytical results are critical.  In common with many other applications, careful sample preparation is critical, especially when the analyte of interest is volatile.

Genevac systems find application in a number of areas, from testing constituents of beverages such as Cognac or gluten levels in Whisky, to pesticide analysis of fruit and vegetables, antibiotic residues in meats or vitamin levels in cereals.  The research and development of Functional Foods where high quality scientific research is carried out also benefits from the speed and quality of a Genevac system.  The EZ-2 or Rocket are commonly used, often in conjunction with SampleGenie™, because this delivers automation of sample transfer and gives unparalleled sample recovery and inter-test reproducibility with very low standard deviations, as the studies from the Laboratoire départemental d'analyses de la Drôme clearly establish.
Concentration technology in Genevac systems has been developed with leading analytical laboratories.  This, with key technologies like Dri-Pure, ensure that samples are concentrated safely and rapidly. SampleGenie™ is a great aid to concentration because the evaporator only evaporates the solvent contained in the large flask, and not the solvent in the vial.  The system detects the end point of evaporation being when the solvent level enters the vial and, once validated, the method will concentrate the sample to the required level.  If a precise volume is required in the vial, then the sample must be over concentrated and then made up to the desired level with pure solvent.

For protein analysis, e.g. for nutritional studies, the EZ-2 with HCI resistance option is ideal.  Protein digests often require digestion with 6N HCl which is highly corrosive to traditional evaporation systems, however, HCl resistant Genevac systems are designed to withstand daily use of concentrated HCl.  

The Rocket has also found an interest application in some of the worlds best restaurants, those that specialise in molecular cuisine, where it is used to concentrate sauces, juices and other natural flavours for the chef to use.  Details of how the Rocket is used can be found in a new book; Modernist Cuisine - the Art and Science of Cooking. The Studio Kitchen blog has some interesting receipe ideas, and some of these are also on Kitchen Theory. 

Useful Papers:

  • An Improved Evaporative Sample Preparation Methodology for Determining Nitrofuran Antibiotic Residues in FoodstuffsKantonales Labor Zurich (KLZH), Zurich, Switzerland 
  • Analysis for pesticides: Method development to increase the recovery of volatile compounds by using EZ-2, a new generation of centrifugal evaporatorEnvironmental Protection Agency of Tuscany (ARPAT), Florence,  Italy        
  • Evaluation of the EZ-2 for Pesticide Analysis Laboratoire départemental d'analyses de la Drôme, Valence, France  
  • Evaluation of SampleGenie™ for Environmental AnalysisLeochimica Laboratories, Zoppola, Italy 
  • Evaluation of the Rocket and SampleGenie for Pesticide AnalysisLaboratoire départemental d'analyses de la Drôme, Valence, France

Proteins & Peptides

Protein concentration is an issue that the biological sciences have been dealing with for years. Many aspects of the study of proteins and exploitation of their therapeutic value requires concentration before and after processing. Each process step can range in scale from setting up a sitting drop of 100nl in microtitre plate based crystallization study to purification of the product from 10,000L fermentation. All of the currently available tools have their draw-backs whether it is from yield loss on membranes to dilution from capture columns.

One of the most commonly used techniques at all scales is membrane concentration. At the small scale this is usually based on concentrators that fit in a centrifuge or small pressure based filers both of which rely on dead-end filtration to push the supernatant through a membrane and retain the protein. The small scale methods used suffer badly from concentration polarization a phenomenon observed in membrane concentrations where the protein concentration at the membrane increases due to the removal of liquid, this is analogous to the cake formed in conventional filtration. In larger applications a cross flow membrane is commonly used where the pressure potential for filtration is provided by a tangential flow to the membrane surface.This cross flow helps to reduce the effect of concentration polarization by sweeping the membrane to clear the retained protein; however, due to constant solvent removal within the system there is still a polarization gradient setup at steady state. When a protein reaches ultra-high concentration at the membrane interface then gel formation is likely this can reduce the activity of the protein and, if the regime for re-suspension is not effective, lead to loss of yield. When we couple this to the non-specific binding effects of most membrane systems it makes this a technique that the industry is using for necessity rather than optimized performance.

One alternative for laboratory scale concentration is to use Centrifugal Vacuum concentration where the solvent is boiled from the supernatant under vacuum so that the temperature of boiling is below the denaturation threshold of the protein. This can dramatically improve both the yield after concentration and also the activity of the protein.This technique would not be used on the large scale but finds a niche in the small scale laboratory work, for example preparation of sample prior to screening against a panel of precipitants to determine the optimum conditions for crystallisation prior to XRD. For hanging and sitting drop experiments concentrations greater than 10 to 20 mg/ml are often required, this is very difficult to achieve in membrane based concentrators due to the limiting factors that have been highlighted above. Where the sample has been purified using reverse phase chromatography (typically peptides), leaving the sample in water and organic solvent, this cannot be concentrated using a membrane because the organic solvents damage the membrane. In a vacuum concentrator the sample remains in a micro-centrifuge tube and the volume remaining can be accurately determined by the time of concentration. One potential limitation of this technique is that the salt and buffer components of the solution will also be concentrated, hence this is ideally suited to be a polishing step that is used after a capture column or membrane concentration step and therefore allows the sample to reach the very high concentrations needed for crystallization. The most commonly used systems for these applications are the miVac range of biological concentrators or the EZ-2.

Peptide Synthesis
Peptide synthesis is normally performed using solid phase supported stub with the sequential addition of protected amino acids. Between each addition step, the protected terminal needs to be deprotected so that the next acid can react and join.  When the desired peptide sequence is complete, it is cleaved from the solid support, usually using a strong acid such as TFA.  The peptide in cleavage cocktail is then dried and purified. Following purification the peptide can be fast lyophilised in a Genevac HT series evaporator or dried using a traditional freeze drier.

Useful Papers:

  • Better Analysis of Insulin Analogues - Dr Catrin Goebel, Australian Sports Drug Testing Lab Examining the effects of sample preparation on data qualityControlled
  • Concentration for MALDI-TOF MS - Steve Knight, GenevacLooking at the effects of sample preparation on MALDI targets in cancer research
Contact us if you are interested in any of the above papers

Using the most advanced proven technology in evaporation science.

EZ-2 series evaporators


Using the most advanced proven technology in evaporation science

The third generation of the EZ-2 Series is the pinnacle of parallel evaporation that draws on the expertise of Genevac engineers and the experiences of many scientists in the laboratory

Racks and Accessories

Brochure

System description

Using the most advanced proven technology in evaporation science, the EZ-2 Series has been designed specifically for solvent removal in many areas of scientific research, whether concentration of samples or complete drying is required.

There are three models in the EZ-2 Series: Standard, Plus & Elite 

• The Standard (EZ-2) is suitable for water and volatile solvents
• The Plus (EZ-2 Plus) is recommended for solvents with boiling points up to 165°C 
• The Elite (EZ-2 Elite) is recommended for solvents with boiling points up to 220°C

Key features: Autostop, Pre-programmed methods, Revolutionary SpeedTrap™ (with autodrain on Elite), DriPure anti-bumping, High boiling point solvents (Elite, )Lyospeed, Fast lyophilisation (Elite)

  • ● Easier to use than a rotary evaporator
  • ● Smart evaporation gives great results every time
  • ● Advanced technology offers total sample protection
  • ● Versatile design accommodates a wide choice of sample types
  • ● All-in-one compact design saves valuable bench space
  • ● Easy maintenance contributes to low cost of ownership

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Application Examples

Clinical and Diagnostic Testing

Evaporative sample preparation for forensic and diagnostic clinical tests must be performed scrupulously. Genevac systems are used by clinical biochemists and forensic scientists for a number of testing methodologies, such as vitamin D or K analysis, neonatal screening and forensic toxicology.

Mass Spectrometry (MS) is replacing radio-immunoassay (RIA) in Clinical biochemistry analysis, removing the need to use radioactive reagents. One of the Steroid assays performed by hospital clinical labs is for Vitamin D analysis where there is a need to identify the relative abundance of vitamin D2 and D3. Samples are typically extracted into Hexane, concentrated (e.g. using a miVac) and analysed by MS (avoiding ion suppression problems often seen with RIA).

Clinical and forensic toxicology investigations also utilise MS methodology, typically with solid phase extraction and evaporation as part of the sample preparation process. Blood and urine analysis can be utilised as part of a medico-legal investigation into drug-related deaths and drug-facilitated crimes and in the clinical assessment of alcohol/drug consumption. Hair analysis can also provide evidence over time of drug or alcohol abuse, as part of programme compliance for those participating in drug or alcohol dependency treatment or for workplace or health insurance screening. The EZ-2 has been used to streamline the sample preparation process whilst maintaining sample integrity and improving sensitivity.

Tandem MS is also used to identify metabolic disorders which include aminoacidemias, urea cycle disorders, organic acidurias, and fatty acid oxidation disorders. Samples can be presented as plasma, urine, and blood spots or urine on filter paper. Sample preparation techniques can include solvent extraction, acid derivitisation and evaporation prior to reconstitution in a suitable medium for injection to MS. Evaporation of butanolic HCl used for derivatisation using blowdown techniques results in corrosion of the system especially pins/needles/jets which can lead to contamination of samples and erroneous results. The EZ-2 with HCI resistance commonly used for these sample preparation stages. One example would be the test for CAT (carnitine acyl carnitine translocase deficiency) in neonates, an inborn error of metabolism. Lack of this enzyme prevents the body from converting fats into energy. Labs do the initial test on Guthrie cards (dried blood spots). The cards are punched and extracted with 200ul of Methanol. The supernatant is placed into microtitre plates and dried. Samples are then derivatised using approx 100ul 3N HCl in anhydrous Butanol and dried again. Finally, samples are re-suspended in Water & acetonitrile for analysis by MS.

miVac concentrators have been used by the Australian Sports Drug Testing Laboratory to improve the testing for synthetic insulin analogues in athletes' blood samples. Using the miVac's ability to control conditions during the concentration step the analyst has more confidence that they are seeing the true blood concentration of potential drugs of abuse in the athlete's sample.


Useful Papers:

  • Evaluation of the EZ-2 for Forensic Toxicology - Dr Eleanor Miller & Dr Simon Elliott, ROAR Forensics, UK. Evaluated the EZ-2 for use concentrating extracts from hair samples to detect alcohol and drugs of abuse metabolites entrained in the samples
  • Evaluation of Evaporative Sample Preparation Techniques for the Extraction of Drugs of Abuse from Urine. Describes the development of a new method for the pre- analytical extraction of drugs of abuse from urine samples pertaining to drug facilitated sexual assault cases. By Forensic Science Ireland (FSI).
  • Better Detection of Insulin Analogues - Great care is required when preparing the samples for analysis, this paper evaluates two possible methods (nitrogen blow down & vacuum concentration) and highlights the pitfalls. Study by Australian Sports Drug Testing Laboratory.

Contact us if you are interested in any of the above papers

DNA & Oligonucleotides

Genevac systems facilitate a wide range of DNA sample preparation and processing activities, ranging from straightforward small volume concentration of DNA pellets prior to PCR, through to high throughput processing of many purified DNA or oligonucleotide samples.  Where a dry sample of DNA is required, concentration to dryness in a centrifugal evaporator is the ideal method, presenting the DNA as a dry film in the tube of plate well.  Freeze drying of DNA samples is not recommended because the resultant DNA powder is easily blown about or moved by electrostatic charges.

DNA Concentration
Concentration of DNA from samples containing water or a mixture of water and alcohols is a simple process, which for most researchers requires the miVac DNA concentrator.  Concentration to remove a few hundred microlitres of alcohol from a DNA pellet takes approximately 10 minutes, or less.   This is one of the simplest applications of a Genevac system – in a miVac DNA concentrator, set the temperature, select the method for alcohols or water, and press start. 

Oligonucleotides & DNA Purification
The manufacture of oligonucleotides commonly has two steps where evaporation is required, evaporation of ammonia solutions following synthesis, and then subsequent evaporation of purified samples.   Protection of oligonucleotides from damage during drying is critical, especially where a tag or label has been attached to the DNA.  Two studies by Genevac users show that this can safely be achieved in a Genevac evaporator: 
  • Comparing Evaporators for Drying Oligonucleotides - Catherine McKeen, Eurogentec SA A Rapid,
  • Safe Technique for Drying Oligonucleotides - Dr Tim Watts, Wellcome Trust Human Genome Centre
Samples containing ammonia solution should be evaporated using Dri-Pure® (500g) to prevent sample loss and cross contamination.  When ammonia solution is subjected to a vacuum the ammonia degasses.  Degassing must be controlled or the resultant foam overflows the tube causing sample loss and cross contamination.  In the same way that you control degassing of a bottle of soda by opening it slowly, gentle application of vacuum is required, this coupled with the high rotors speeds of Dri-Pure keep every sample where it should be.  The latest versions of the EZ-2 come with such a method pre-programmed, and the method is simple to program on the HT-Series.
  
Where samples have been purified by reverse phase HPLC samples are presented in a mixture of water and methanol or acetonitrile.  The methods laid out in the Post Purification Sample Handling section should be followed.  The imbalance tolerance built into Genevac systems gives researchers confidence that eluates at different ends of the gradient will still dry down, and if there is too much imbalance the system will automatically shut down and tell the user.

Preparation of DNA Microarrays
For certain microarraying techniques concentrated samples of DNA are required.  To maintain such a concentration is difficult due to the volatile nature of the buffers holding the DNA, therefore samples should be made up to the required volume immediately prior to analysis.  A study by the Wellcome Trust Centre for Human Genetics in Oxford has shown that when an EZ-2 is used in this process the data quality returned by the system is significantly better, reducing the no call rate by 80% or more.

Environmental Analysis

Monitoring of the environment for substances potentially harmful to health is a core activity not just for government departments but for many organisations who wish to ensure that they are not harming their staff or the environment.  Samples of air, water, soil or plant matter are routinely monitored for the presence of potentially harmful substances – for example, pesticides in river water or the soil. Foodstuffs are similarly monitored.

When testing the water quality of a river, a point sample only provides a snap-shot of the situation, where as monitoring over a period of time will help present a better overall picture and can indicate where there is chronic build-up of a potentially harmful substance(s).  Samples of tissue are often taken from fish living in the river are examined to determine the nature of any chemicals in the water.  Another more recent approach is to use a virtual fish, a semi-permeable membrane device (SPMD) developed by the US Geological Survey.  This is placed in the river for a period of time, and then any organic chemicals are extracted with solvent, concentrated and analysed as they would be from a fish.

Air quality can be monitored similarly by filtering air for a period of time, extracting the filter, and then concentrating and analysing whatever organic molecules may be trapped on the filter.  This is a key activity in industrial environments where PAHs may be a risk factor for workers.

When concentrating samples the EZ-2 (small volumes) and Rocket (large volumes) are ideal tools for concentrating in the analytical laboratory.  Coupled with SampleGenie they enhance analyte recovery, reduce inter-sample variability and free workers to do more productive tasks than monitoring a concentration system. SampleGenie enables large volume samples to be concentrated directly into an autosampler vial, eliminating the need to transfer the sample. 

Useful Papers:
Improving Analysis of Airborne PAHs
Detectionand Quantification of Algal Toxins in Surface Water
Analysis of Glyphosate and its degradation Products in Surface Water


Food & Beverage

Quality and safety testing of food and beverages is an area of growing importance, be that for exporters, importers or government bodies, accurate analytical results are critical.  In common with many other applications, careful sample preparation is critical, especially when the analyte of interest is volatile.

Genevac systems find application in a number of areas, from testing constituents of beverages such as Cognac or gluten levels in Whisky, to pesticide analysis of fruit and vegetables, antibiotic residues in meats or vitamin levels in cereals.  The research and development of Functional Foods where high quality scientific research is carried out also benefits from the speed and quality of a Genevac system.  The EZ-2 or Rocket are commonly used, often in conjunction with SampleGenie™, because this delivers automation of sample transfer and gives unparalleled sample recovery and inter-test reproducibility with very low standard deviations, as the studies from the Laboratoire départemental d'analyses de la Drôme clearly establish.
Concentration technology in Genevac systems has been developed with leading analytical laboratories.  This, with key technologies like Dri-Pure, ensure that samples are concentrated safely and rapidly. SampleGenie™ is a great aid to concentration because the evaporator only evaporates the solvent contained in the large flask, and not the solvent in the vial.  The system detects the end point of evaporation being when the solvent level enters the vial and, once validated, the method will concentrate the sample to the required level.  If a precise volume is required in the vial, then the sample must be over concentrated and then made up to the desired level with pure solvent.

For protein analysis, e.g. for nutritional studies, the EZ-2 with HCI resistance option is ideal.  Protein digests often require digestion with 6N HCl which is highly corrosive to traditional evaporation systems, however, HCl resistant Genevac systems are designed to withstand daily use of concentrated HCl.  

The Rocket has also found an interest application in some of the worlds best restaurants, those that specialise in molecular cuisine, where it is used to concentrate sauces, juices and other natural flavours for the chef to use.  Details of how the Rocket is used can be found in a new book; Modernist Cuisine - the Art and Science of Cooking. The Studio Kitchen blog has some interesting receipe ideas, and some of these are also on Kitchen Theory. 

Useful Papers:

  • An Improved Evaporative Sample Preparation Methodology for Determining Nitrofuran Antibiotic Residues in FoodstuffsKantonales Labor Zurich (KLZH), Zurich, Switzerland 
  • Analysis for pesticides: Method development to increase the recovery of volatile compounds by using EZ-2, a new generation of centrifugal evaporatorEnvironmental Protection Agency of Tuscany (ARPAT), Florence,  Italy        
  • Evaluation of the EZ-2 for Pesticide Analysis Laboratoire départemental d'analyses de la Drôme, Valence, France  
  • Evaluation of SampleGenie™ for Environmental AnalysisLeochimica Laboratories, Zoppola, Italy 
  • Evaluation of the Rocket and SampleGenie for Pesticide AnalysisLaboratoire départemental d'analyses de la Drôme, Valence, France

Metabolism & Toxicology Studies

Metabolic and Toxicology studies look at the passage of a drug or chemical into and through the body.  They range from routine safety screening for workers potentially at risk to chemicals through to pharmaceutical drug safety testing and drug prescription compliance and monitoring in the clinical environment.  Genevac systems provide an invaluable tool to researchers in these environments, providing fast, safe evaporative sample preparation free from artefact, contamination and sample loss.Metabolic and Toxicology studies look at the passage of a drug or chemical into and through the body.  They range from routine safety screening for workers potentially at risk to chemicals through to pharmaceutical drug safety testing and drug prescription compliance and monitoring in the clinical environment.  Genevac systems provide an invaluable tool to researchers in these environments, providing fast, safe evaporative sample preparation free from artefact, contamination and sample loss.
 
Applications range from the relatively simple concentration or drying of solvent extracts from tissue samples to qualitatively analyse for the presence of a drug.  Two studies using a miVac Concentrator focus on this work:
  • Better Analasys of Insulin Analogues - Dr Catrin Goebel, Australian Sports Drug Testing Lab 
  • Detection of Diclofenac Residues in Wildlife - Dr Ngaio Richards, Anglia Ruskin University


More complex metabolic studies utilize labelled drug molecules which are fed to subjects.  Samples are taken, extracted and separated via HPLC.  Multiple samples are often collected in scintillant containing microtitre plates, such as the LumaPlate.  These must be carefully dried before analysis via a luminescence reader such as a TopCount.  If the plates are crudely dried the labelled molecule does not come into intimate contact with the scintillant providing a false reading.  The Genevac EZ-2 and HT-4X have been shown to be excellent for this purpose.
 
Customers working with larger volumes have shown that SampleGenie is a useful tool to help automate their sample transfer process without adverse effect on sample recovery.  

Useful Papers: 

  • Evaluation of the EZ-2 for Forensic Toxicology - Dr Eleanor Miller & Dr Simon Elliott, ROAR Forensics, UK.  Evaluated the EZ-2 for use concentrating extracts from hair samples to detect alcohol and drugs of abuse metabolites entrained in the samples. 
  • Increasing Metabolite Recoveries in ADMET Studies - Dr Sophie Mcdougall, Sanofi Aventis. Studies showed that by using a Genevac HT-4 evaporator and Luma plates can increase the sensitivity and hence the recoveries as the extra gravitational force applied helps the sample mixture to dry as a tight pellet at the bottom of the well. 
  • Automation without Robotics - Peter Bennett, Drug Metabolism group at Servier ResearchEvaluation of SampleGenie™ in their laboratory 
  • Advances in Sample-prep for Metabolite Profiling - Dr Flavio Cinato, Nerviano MSTrials with EZ-2 showed that the optimal balance between speed and minimal compound degradation.  
  • Improving Productivity in Toxicology Screening - Rob Darrington, GenevacUsing a modern centrifugal evaporator like Genevac EZ-2 provides automation, user safety, reliability of the analysis and productivity

If you are interested in any of these papers please contatc us.





Natural Products Research

Natural products are researched for many reasons, from biodiversity preservation through flavour or fragrance research, to finding a cure for disease.  Whatever your reason, Genevac systems are used by researchers who are investigating the properties of the natural environment. 

For basic botanical and biological research, the miVac concentrator range are the mainstay for those extracting and purifying DNA or proteins for genome and proteome research.

Genevac systems are widely used by researchers seeking to extract functional molecules from natural sources.  A typical process would be to take a tissue (or micro-organism broth) sample and then perform a primary solvent extraction resulting in a large volume of crude extract.  The crude extract is often concentrated, for which the Rocket Evaporator is ideal, before being fractionated to isolate each component.  Fractionation may use a system such at the Sepbox, one, or two dimensional chromatography which produces many samples from one extract.  These samples need to be evaporated before storage or analysis and may require lyophilisation. Genevac HT series evaporators are used for this purpose. 

Useful Papers:

  • High Throughput Natural Product Discovery - a paper by Stephen Pickrahn, IFF 
  • Rapid Evaporation Processes to Enhance Natural Product Extraction - by Dr John Hester, Principal R&D Engineer – Natural Product Repository Supervisor, University of Mississippi

Parallel Chemistry

Genevac evaporators have been designed from the outset to be robust and withstand the rigors of working in the chemistry laboratory.  Systems were used in the early days for Combinatorial Chemistry where routine use of 100% TFA has given systems a tough field testing. 
Whether working in drug discovery, flavour or fragrence research, liquid chrystal synthesis or academic reaserch, Genevac systems are the ideal tool for use when performing parallel chemistry.  When working with a single sample then a rotary evaporator is ideal, whereas, when you have multiple samples this would be a bottleneck.  Spending time just watching a rotary evaporator is not very efficient!
  • The main uses for Genevac systems are:
  • ● Solvent exchange – removal of reaction solvents between stages
  • ● Re-salt formation – removal of strong acids of bases when changing salt forms.  Genevac have a special option for HCl resistance which enables the use of concentrated HCl – ideal for this purpose.
  • ● Post Purification Handling – removing purification solvents following normal phase, reverse phase or chiral separation. Genevac also offer SampleGenie to enable a large volume to be dried directly into a small storage which eliminates the need to reformat samples from a flask into a vial.  Reverse phase HPLC fractions may also be fast lyophilised in some Genevac systems.
  • ● Compound logistics - transfer to and management of samples in storage conditions and systems, this is often done using DMSO, a notoriously difficult to evaporate high boiling point solvent.
  • Depending on the number and nature of samples then one of several Genevac systems may be suitable – the EZ-2 and HT series are designed for working with smaller samples in plates, tubes and vials.  When working with large volumes in flasks – then the Rocket evaporator is the most suitable, taking up to 6 flasks.

Useful Papers:

  • Reactions involving HCl and their Evaporation - Dr Induka Abeysena, Genevac 
  • Development of an Evaporator for High Throughput Chemistry- Dr Tom Smith, GSK 
  • Surviving TFA - Application Note Parallel Dry-Loading of Synthesis Samples onto Silica for Analysis- Dr Nigel Vicker, Bath University Pharmacy Department  
  • Library Maintenance for the Smaller Pharma Company - poster by Dr Sally Hampton, Ferring Pharmaceuticals 
  • How to Evaporate High Boiling Point Solvents - Application Note

Contact us if you are interested in any of the above papers

Proteins & Peptides

Protein concentration is an issue that the biological sciences have been dealing with for years. Many aspects of the study of proteins and exploitation of their therapeutic value requires concentration before and after processing. Each process step can range in scale from setting up a sitting drop of 100nl in microtitre plate based crystallization study to purification of the product from 10,000L fermentation. All of the currently available tools have their draw-backs whether it is from yield loss on membranes to dilution from capture columns.

One of the most commonly used techniques at all scales is membrane concentration. At the small scale this is usually based on concentrators that fit in a centrifuge or small pressure based filers both of which rely on dead-end filtration to push the supernatant through a membrane and retain the protein. The small scale methods used suffer badly from concentration polarization a phenomenon observed in membrane concentrations where the protein concentration at the membrane increases due to the removal of liquid, this is analogous to the cake formed in conventional filtration. In larger applications a cross flow membrane is commonly used where the pressure potential for filtration is provided by a tangential flow to the membrane surface.This cross flow helps to reduce the effect of concentration polarization by sweeping the membrane to clear the retained protein; however, due to constant solvent removal within the system there is still a polarization gradient setup at steady state. When a protein reaches ultra-high concentration at the membrane interface then gel formation is likely this can reduce the activity of the protein and, if the regime for re-suspension is not effective, lead to loss of yield. When we couple this to the non-specific binding effects of most membrane systems it makes this a technique that the industry is using for necessity rather than optimized performance.

One alternative for laboratory scale concentration is to use Centrifugal Vacuum concentration where the solvent is boiled from the supernatant under vacuum so that the temperature of boiling is below the denaturation threshold of the protein. This can dramatically improve both the yield after concentration and also the activity of the protein.This technique would not be used on the large scale but finds a niche in the small scale laboratory work, for example preparation of sample prior to screening against a panel of precipitants to determine the optimum conditions for crystallisation prior to XRD. For hanging and sitting drop experiments concentrations greater than 10 to 20 mg/ml are often required, this is very difficult to achieve in membrane based concentrators due to the limiting factors that have been highlighted above. Where the sample has been purified using reverse phase chromatography (typically peptides), leaving the sample in water and organic solvent, this cannot be concentrated using a membrane because the organic solvents damage the membrane. In a vacuum concentrator the sample remains in a micro-centrifuge tube and the volume remaining can be accurately determined by the time of concentration. One potential limitation of this technique is that the salt and buffer components of the solution will also be concentrated, hence this is ideally suited to be a polishing step that is used after a capture column or membrane concentration step and therefore allows the sample to reach the very high concentrations needed for crystallization. The most commonly used systems for these applications are the miVac range of biological concentrators or the EZ-2.

Peptide Synthesis
Peptide synthesis is normally performed using solid phase supported stub with the sequential addition of protected amino acids. Between each addition step, the protected terminal needs to be deprotected so that the next acid can react and join.  When the desired peptide sequence is complete, it is cleaved from the solid support, usually using a strong acid such as TFA.  The peptide in cleavage cocktail is then dried and purified. Following purification the peptide can be fast lyophilised in a Genevac HT series evaporator or dried using a traditional freeze drier.

Useful Papers:

  • Better Analysis of Insulin Analogues - Dr Catrin Goebel, Australian Sports Drug Testing Lab Examining the effects of sample preparation on data qualityControlled
  • Concentration for MALDI-TOF MS - Steve Knight, GenevacLooking at the effects of sample preparation on MALDI targets in cancer research
Contact us if you are interested in any of the above papers

Post Purification Sample Handling

Depending on the process, and therefore the nature of the samples, then Genevac provides a number of solutions to facilitate post purification sample handling, including reformatting.

  • Normal Phase HPLC, SFC or Flash chromatography – removal of organic solvents is simple in a Genevac evaporator. Evaporation of Solvent Mixtures is safe when using Dri-Pure which eliminates the effects of bumping.
  • Reverse Phase HPLC– evaporation of water and acetonitrile (or methanol) is the principal application of many Genevac systems.  A multiple stage method has been developed to remove the organic solvent without freezing the water, remove the water, and then dry any remaining stubborn solvent.  Alternatively, the LyoSpeed fast lyopilisation method can be used in Genevac HT series evaporators.  Recent advances in condenser technology, in particular the high power -75°C cold trap available with the HT-8 or HT-12, have lead to significant advances in lyophilisation success rates.

Post Purification Handling following removal of purification solvents the sample typically needs to be reformatting from the fraction tubes or flask, into a small vial for compound storage. Genevac developed SampleGenie to enable a large volume to be dried (or lyophilised) directly into a small storage vial which eliminates the need to reformat samples from a flask or multiple tubes into a vial.

Depending on the number and nature of samples then one of several Genevac systems may be suitable – the EZ-2 and HT series are designed for working with smaller samples in plates, tubes and vials.  When working with large volumes in flasks – then the Rocket evaporator is the most suitable, taking up to 6 flasks.

Useful Papers: 
  • Drying HPLC Fractions - applications note 
  • Fast Lyophilisation for HPLC Fractions - Dr Induka Abeysena & Rob Darrington  
  • Enhanced LyoSpeed™ with a -75°C Condenser - Rob Darrington 
  • Integration for High Throughput HPLC Purification - Paul de Fraine, Syngenta & Dr Mike Jones 
  • Drying Solvent Mixtures - applications note 
  • Evaluation of the Rocket Evaporation System - paper by Christine Prosser et al., UCB
  • Automation of reverse phase HPLC fraction pooling, evaporation, and reformatting
Contact us if you are interested in any of the above papers

Oils, Fuels and Fats

Working with oils, fuels and fats can be difficult.  Whether extracting & recovering additives, evaluating lipid content of foods, characterising reclaimed cooking oils before reprocessing or conversion to biofuels, or investigating drillling test samples - oils can be difficult to dry in turn leading to problems with the analytical instrumentation.   

Extraction and separation techniques, be they basic dialysis, Dionex ASE or Counter Current Chromatography, all normally present the sample in a solution of organic solvent.  The sample typcially must be dried or concentrated before analysis.  Drying all the solvent can be difficult without using very high temperatures or other harsh regimens which may lead to loss of more volatile fractions within the oil.  For many such applications, researchers have found that the EZ-2 and the Rocket Evaporator have delivered significant enhancement to their recovery and results.  When working with larger solvent volumes, additional benefit is gained by way of  productivity savings when used with SampleGenie which enables large volumes to be concentrated or dried directly into a small vial.

The ultimate in solvent removal technology.

      

HT-6 and HT-12 evaporators


The ultimate in solvent removal technology

Genevac HT series evaporators are the ideal solution for parallel evaporation bottlenecks in high throughput and production laboratories having high performance and high sample capacities.

Racks and accessories

Brochure

System description

The all new Series 3 HT evaporator range from Genevac represents the ultimate in solvent removal technology. Incorporating new high performance vacuum pump, the latest touchscreen technology and a sleek ergonomic design makes optimising your evaporation processes effortless.

New intuitive touchscreen controls enhances monitoring and review of the whole evaporation process. For popular solvent removal protocols pre-set "Press & Go" methods makes operation easy and productive even for occasional users. Simplified manual and automatic programming means even the most complex multi-stage evaporation methods can be set-up and run quickly and easily.
Peace of mind comes as standard with patented temperature control and bumping prevention built in.
  • ● High throughput evaporation
  • ● High speed evaporation
  • ● Fast lyophilisation capability
  • ● New intuitive touchscreen control system for ultimate ease of use
  • ● Integrated condenser meaning a smaller system footprint
  • ● Front opening for easy access
  • ● DriPure anti-bumping

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Application Examples

Parallel Chemistry

Genevac evaporators have been designed from the outset to be robust and withstand the rigors of working in the chemistry laboratory.  Systems were used in the early days for Combinatorial Chemistry where routine use of 100% TFA has given systems a tough field testing. 
Whether working in drug discovery, flavour or fragrence research, liquid chrystal synthesis or academic reaserch, Genevac systems are the ideal tool for use when performing parallel chemistry.  When working with a single sample then a rotary evaporator is ideal, whereas, when you have multiple samples this would be a bottleneck.  Spending time just watching a rotary evaporator is not very efficient!
  • The main uses for Genevac systems are:
  • ● Solvent exchange – removal of reaction solvents between stages
  • ● Re-salt formation – removal of strong acids of bases when changing salt forms.  Genevac have a special option for HCl resistance which enables the use of concentrated HCl – ideal for this purpose.
  • ● Post Purification Handling – removing purification solvents following normal phase, reverse phase or chiral separation. Genevac also offer SampleGenie to enable a large volume to be dried directly into a small storage which eliminates the need to reformat samples from a flask into a vial.  Reverse phase HPLC fractions may also be fast lyophilised in some Genevac systems.
  • ● Compound logistics - transfer to and management of samples in storage conditions and systems, this is often done using DMSO, a notoriously difficult to evaporate high boiling point solvent.
  • Depending on the number and nature of samples then one of several Genevac systems may be suitable – the EZ-2 and HT series are designed for working with smaller samples in plates, tubes and vials.  When working with large volumes in flasks – then the Rocket evaporator is the most suitable, taking up to 6 flasks.

Useful Papers:

  • Reactions involving HCl and their Evaporation - Dr Induka Abeysena, Genevac 
  • Development of an Evaporator for High Throughput Chemistry- Dr Tom Smith, GSK 
  • Surviving TFA - Application Note Parallel Dry-Loading of Synthesis Samples onto Silica for Analysis- Dr Nigel Vicker, Bath University Pharmacy Department  
  • Library Maintenance for the Smaller Pharma Company - poster by Dr Sally Hampton, Ferring Pharmaceuticals 
  • How to Evaporate High Boiling Point Solvents - Application Note

Contact us if you are interested in any of the above papers

Post Purification Sample Handling

Depending on the process, and therefore the nature of the samples, then Genevac provides a number of solutions to facilitate post purification sample handling, including reformatting.

  • Normal Phase HPLC, SFC or Flash chromatography – removal of organic solvents is simple in a Genevac evaporator. Evaporation of Solvent Mixtures is safe when using Dri-Pure which eliminates the effects of bumping.
  • Reverse Phase HPLC– evaporation of water and acetonitrile (or methanol) is the principal application of many Genevac systems.  A multiple stage method has been developed to remove the organic solvent without freezing the water, remove the water, and then dry any remaining stubborn solvent.  Alternatively, the LyoSpeed fast lyopilisation method can be used in Genevac HT series evaporators.  Recent advances in condenser technology, in particular the high power -75°C cold trap available with the HT-8 or HT-12, have lead to significant advances in lyophilisation success rates.

Post Purification Handling following removal of purification solvents the sample typically needs to be reformatting from the fraction tubes or flask, into a small vial for compound storage. Genevac developed SampleGenie to enable a large volume to be dried (or lyophilised) directly into a small storage vial which eliminates the need to reformat samples from a flask or multiple tubes into a vial.

Depending on the number and nature of samples then one of several Genevac systems may be suitable – the EZ-2 and HT series are designed for working with smaller samples in plates, tubes and vials.  When working with large volumes in flasks – then the Rocket evaporator is the most suitable, taking up to 6 flasks.

Useful Papers: 
  • Drying HPLC Fractions - applications note 
  • Fast Lyophilisation for HPLC Fractions - Dr Induka Abeysena & Rob Darrington  
  • Enhanced LyoSpeed™ with a -75°C Condenser - Rob Darrington 
  • Integration for High Throughput HPLC Purification - Paul de Fraine, Syngenta & Dr Mike Jones 
  • Drying Solvent Mixtures - applications note 
  • Evaluation of the Rocket Evaporation System - paper by Christine Prosser et al., UCB
  • Automation of reverse phase HPLC fraction pooling, evaporation, and reformatting
Contact us if you are interested in any of the above papers

Controlled Crystallisation

Crystallisation is a critical process in the development of many compounds. It can form part of the purifications or separation stage and can influence yield purity and particle size. In API development particularly the identification of different crystalline polymorphs and confirmation of stable & metastable forms is very important.

Chemists achieve crystalisation by many varied methods. Variation in temperature, solvent, head pressure, seeding method and evaporation rate can all have effects on the crystallisation process, influencing the form, shape and size of crystals formed. However for many methods used there is little control and often no reproducibility of these parameters. Such studies can also be time consuming and difficult to conduct

EXALT is a unique toolkit developed by Genevac and researchers in the field to assist with evaporative crystallisation studies in a number ways. By enabling a wide range of solvents to be evaporated at the same time and at the same slow rate, the EXALT system can deliver crystalline forms of a compound in a controlled and reproducible manner. It gives control to the operator by removing a number variables which are often present in current methods for crystallisation studies.

EXALT has been shown to be a useful tool for confirmation of stable forms, to create crystals from amorphous forms, to screen solvents for crystal production including production of seed crystals, and in co-crystal screening.

eXalt Brochure

Environmental Analysis

Monitoring of the environment for substances potentially harmful to health is a core activity not just for government departments but for many organisations who wish to ensure that they are not harming their staff or the environment.  Samples of air, water, soil or plant matter are routinely monitored for the presence of potentially harmful substances – for example, pesticides in river water or the soil. Foodstuffs are similarly monitored.

When testing the water quality of a river, a point sample only provides a snap-shot of the situation, where as monitoring over a period of time will help present a better overall picture and can indicate where there is chronic build-up of a potentially harmful substance(s).  Samples of tissue are often taken from fish living in the river are examined to determine the nature of any chemicals in the water.  Another more recent approach is to use a virtual fish, a semi-permeable membrane device (SPMD) developed by the US Geological Survey.  This is placed in the river for a period of time, and then any organic chemicals are extracted with solvent, concentrated and analysed as they would be from a fish.

Air quality can be monitored similarly by filtering air for a period of time, extracting the filter, and then concentrating and analysing whatever organic molecules may be trapped on the filter.  This is a key activity in industrial environments where PAHs may be a risk factor for workers.

When concentrating samples the EZ-2 (small volumes) and Rocket (large volumes) are ideal tools for concentrating in the analytical laboratory.  Coupled with SampleGenie they enhance analyte recovery, reduce inter-sample variability and free workers to do more productive tasks than monitoring a concentration system. SampleGenie enables large volume samples to be concentrated directly into an autosampler vial, eliminating the need to transfer the sample. 

Useful Papers:
Improving Analysis of Airborne PAHs
Detectionand Quantification of Algal Toxins in Surface Water
Analysis of Glyphosate and its degradation Products in Surface Water


Metabolism & Toxicology Studies

Metabolic and Toxicology studies look at the passage of a drug or chemical into and through the body.  They range from routine safety screening for workers potentially at risk to chemicals through to pharmaceutical drug safety testing and drug prescription compliance and monitoring in the clinical environment.  Genevac systems provide an invaluable tool to researchers in these environments, providing fast, safe evaporative sample preparation free from artefact, contamination and sample loss.Metabolic and Toxicology studies look at the passage of a drug or chemical into and through the body.  They range from routine safety screening for workers potentially at risk to chemicals through to pharmaceutical drug safety testing and drug prescription compliance and monitoring in the clinical environment.  Genevac systems provide an invaluable tool to researchers in these environments, providing fast, safe evaporative sample preparation free from artefact, contamination and sample loss.
 
Applications range from the relatively simple concentration or drying of solvent extracts from tissue samples to qualitatively analyse for the presence of a drug.  Two studies using a miVac Concentrator focus on this work:
  • Better Analasys of Insulin Analogues - Dr Catrin Goebel, Australian Sports Drug Testing Lab 
  • Detection of Diclofenac Residues in Wildlife - Dr Ngaio Richards, Anglia Ruskin University


More complex metabolic studies utilize labelled drug molecules which are fed to subjects.  Samples are taken, extracted and separated via HPLC.  Multiple samples are often collected in scintillant containing microtitre plates, such as the LumaPlate.  These must be carefully dried before analysis via a luminescence reader such as a TopCount.  If the plates are crudely dried the labelled molecule does not come into intimate contact with the scintillant providing a false reading.  The Genevac EZ-2 and HT-4X have been shown to be excellent for this purpose.
 
Customers working with larger volumes have shown that SampleGenie is a useful tool to help automate their sample transfer process without adverse effect on sample recovery.  

Useful Papers: 

  • Evaluation of the EZ-2 for Forensic Toxicology - Dr Eleanor Miller & Dr Simon Elliott, ROAR Forensics, UK.  Evaluated the EZ-2 for use concentrating extracts from hair samples to detect alcohol and drugs of abuse metabolites entrained in the samples. 
  • Increasing Metabolite Recoveries in ADMET Studies - Dr Sophie Mcdougall, Sanofi Aventis. Studies showed that by using a Genevac HT-4 evaporator and Luma plates can increase the sensitivity and hence the recoveries as the extra gravitational force applied helps the sample mixture to dry as a tight pellet at the bottom of the well. 
  • Automation without Robotics - Peter Bennett, Drug Metabolism group at Servier ResearchEvaluation of SampleGenie™ in their laboratory 
  • Advances in Sample-prep for Metabolite Profiling - Dr Flavio Cinato, Nerviano MSTrials with EZ-2 showed that the optimal balance between speed and minimal compound degradation.  
  • Improving Productivity in Toxicology Screening - Rob Darrington, GenevacUsing a modern centrifugal evaporator like Genevac EZ-2 provides automation, user safety, reliability of the analysis and productivity

If you are interested in any of these papers please contatc us.





Natural Products Research

Natural products are researched for many reasons, from biodiversity preservation through flavour or fragrance research, to finding a cure for disease.  Whatever your reason, Genevac systems are used by researchers who are investigating the properties of the natural environment. 

For basic botanical and biological research, the miVac concentrator range are the mainstay for those extracting and purifying DNA or proteins for genome and proteome research.

Genevac systems are widely used by researchers seeking to extract functional molecules from natural sources.  A typical process would be to take a tissue (or micro-organism broth) sample and then perform a primary solvent extraction resulting in a large volume of crude extract.  The crude extract is often concentrated, for which the Rocket Evaporator is ideal, before being fractionated to isolate each component.  Fractionation may use a system such at the Sepbox, one, or two dimensional chromatography which produces many samples from one extract.  These samples need to be evaporated before storage or analysis and may require lyophilisation. Genevac HT series evaporators are used for this purpose. 

Useful Papers:

  • High Throughput Natural Product Discovery - a paper by Stephen Pickrahn, IFF 
  • Rapid Evaporation Processes to Enhance Natural Product Extraction - by Dr John Hester, Principal R&D Engineer – Natural Product Repository Supervisor, University of Mississippi

For drying or concentrating very large volumes.

Rocket 4D Synergy


For drying or concentrating very large volumes

Designed primarily to evaporate large sample volumes (of 5 litres and above), with autofeed if required.

Brochure

System description

Rocket 4D Synergy is a fully automated system for drying or concentrating very large volumes with no user intervention and in complete confidence. Designed primarily to evaporate large sample volumes (of 5 litres and above), with autofeed if required, the Rocket 4D Synergy can also be fitted with a removable flask rotor to accommodate the full range of Rocket Sample handling solutions such as flasks, tubes and SampleGenie.

Now you don't need to choose between flask, batch or feed evaporation. The Rocket Synergy evaporator will accommodate your process, whatever the volume. Each is capable of replacing several rotary evaporators and saving valuable bench space.

Key features: High speed evaporation, High volume evaporation - Sample volumes from 50ml to 100 liters, Autofeed, Autostop, Unique Rocket low pressure steam heat transfer technology, DriPure anti bumping, Removable interchangeable rotors, Autodraining condenser, Strobe to view evaporation progress
  • ● Easy to use – simple controls and intelligent software
  • ● Fully automated from start to finish
  • ● Space saving –one Rocket replaces several rotary evaporators
  • ● Perfect results – no monitoring or intervention required for excellent sample recovery
  • ● Environmentally friendly cold traps and advanced methodology provide very high solvent recovery

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Applications

Rocket 4D Synergy is a fully automated system for drying or concentrating very large volumes with no user intervention and in complete confidence –no bumping, foaming or sample loss. Simply load your sample, select the correct method,press start, and walk away –the system will do the rest.The Rocket 4D Synergy can also befitted with a removable flask rotor to accommodate the full range of Rocket Sample handling solutions such as flasks, tubes and SampleGenie.

Options

Space saving –one Rocket replaces several rotary evaporators.

Rocket Synergy


Space saving –one Rocket replaces several rotary evaporators

Designed to dry or concentrate up to six flasks, each containing a maximum of 450ml of solvent, or 18 ASE® vials, with no user intervention or attention

Options for Rocket Synergy

Brochure

System description

The removable flask rotor may also be replaced with a 5 litre stainless steel vessel for batch processing
.
Rocket controls are very easy to use. Load your samples, select the correct method,press start and walk away. The evaporator is equipped with high performance features that prevent foaming, bumping and cross contamination. A built-in cold trap provides very high levels of solvent recovery, even with volatile organic solvents. Auto-draining, under the control of the Rocket, ensures optimal solvent recovery is maintained under all conditions.

Now you don't need to choose between flask or batch evaporation. The Rocket Synergy evaporator will accommodate your process, whatever the volume. Each is capable of replacing several rotary evaporators and saving valuable bench space.

Key features: High speed evaporation, High speed evaporation, Autostop, Unique Rocket low pressure steam heat transfer technology, DriPure anti bumping, Sample volumes from 50ml to 5 litres, Removable interchangeable rotors, Autodraining condenser, Strobe to view evaporation progress
  • ● Easy to use – simple controls and intelligent software
  • ● Fully automated from start to finish
  • ● Space saving –one Rocket replaces several rotary evaporators
  • ● Perfect results – no monitoring or intervention required for excellent sample recovery
  • ● Environmentally friendly cold traps and advanced methodology provide very high solvent recovery

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Application Examples

Parallel Chemistry

Genevac evaporators have been designed from the outset to be robust and withstand the rigors of working in the chemistry laboratory.  Systems were used in the early days for Combinatorial Chemistry where routine use of 100% TFA has given systems a tough field testing. 
Whether working in drug discovery, flavour or fragrence research, liquid chrystal synthesis or academic reaserch, Genevac systems are the ideal tool for use when performing parallel chemistry.  When working with a single sample then a rotary evaporator is ideal, whereas, when you have multiple samples this would be a bottleneck.  Spending time just watching a rotary evaporator is not very efficient!
  • The main uses for Genevac systems are:
  • ● Solvent exchange – removal of reaction solvents between stages
  • ● Re-salt formation – removal of strong acids of bases when changing salt forms.  Genevac have a special option for HCl resistance which enables the use of concentrated HCl – ideal for this purpose.
  • ● Post Purification Handling – removing purification solvents following normal phase, reverse phase or chiral separation. Genevac also offer SampleGenie to enable a large volume to be dried directly into a small storage which eliminates the need to reformat samples from a flask into a vial.  Reverse phase HPLC fractions may also be fast lyophilised in some Genevac systems.
  • ● Compound logistics - transfer to and management of samples in storage conditions and systems, this is often done using DMSO, a notoriously difficult to evaporate high boiling point solvent.
  • Depending on the number and nature of samples then one of several Genevac systems may be suitable – the EZ-2 and HT series are designed for working with smaller samples in plates, tubes and vials.  When working with large volumes in flasks – then the Rocket evaporator is the most suitable, taking up to 6 flasks.

Useful Papers:

  • Reactions involving HCl and their Evaporation - Dr Induka Abeysena, Genevac 
  • Development of an Evaporator for High Throughput Chemistry- Dr Tom Smith, GSK 
  • Surviving TFA - Application Note Parallel Dry-Loading of Synthesis Samples onto Silica for Analysis- Dr Nigel Vicker, Bath University Pharmacy Department  
  • Library Maintenance for the Smaller Pharma Company - poster by Dr Sally Hampton, Ferring Pharmaceuticals 
  • How to Evaporate High Boiling Point Solvents - Application Note

Contact us if you are interested in any of the above papers

Food & Beverage

Quality and safety testing of food and beverages is an area of growing importance, be that for exporters, importers or government bodies, accurate analytical results are critical.  In common with many other applications, careful sample preparation is critical, especially when the analyte of interest is volatile.

Genevac systems find application in a number of areas, from testing constituents of beverages such as Cognac or gluten levels in Whisky, to pesticide analysis of fruit and vegetables, antibiotic residues in meats or vitamin levels in cereals.  The research and development of Functional Foods where high quality scientific research is carried out also benefits from the speed and quality of a Genevac system.  The EZ-2 or Rocket are commonly used, often in conjunction with SampleGenie™, because this delivers automation of sample transfer and gives unparalleled sample recovery and inter-test reproducibility with very low standard deviations, as the studies from the Laboratoire départemental d'analyses de la Drôme clearly establish.
Concentration technology in Genevac systems has been developed with leading analytical laboratories.  This, with key technologies like Dri-Pure, ensure that samples are concentrated safely and rapidly. SampleGenie™ is a great aid to concentration because the evaporator only evaporates the solvent contained in the large flask, and not the solvent in the vial.  The system detects the end point of evaporation being when the solvent level enters the vial and, once validated, the method will concentrate the sample to the required level.  If a precise volume is required in the vial, then the sample must be over concentrated and then made up to the desired level with pure solvent.

For protein analysis, e.g. for nutritional studies, the EZ-2 with HCI resistance option is ideal.  Protein digests often require digestion with 6N HCl which is highly corrosive to traditional evaporation systems, however, HCl resistant Genevac systems are designed to withstand daily use of concentrated HCl.  

The Rocket has also found an interest application in some of the worlds best restaurants, those that specialise in molecular cuisine, where it is used to concentrate sauces, juices and other natural flavours for the chef to use.  Details of how the Rocket is used can be found in a new book; Modernist Cuisine - the Art and Science of Cooking. The Studio Kitchen blog has some interesting receipe ideas, and some of these are also on Kitchen Theory. 

Useful Papers:

  • An Improved Evaporative Sample Preparation Methodology for Determining Nitrofuran Antibiotic Residues in FoodstuffsKantonales Labor Zurich (KLZH), Zurich, Switzerland 
  • Analysis for pesticides: Method development to increase the recovery of volatile compounds by using EZ-2, a new generation of centrifugal evaporatorEnvironmental Protection Agency of Tuscany (ARPAT), Florence,  Italy        
  • Evaluation of the EZ-2 for Pesticide Analysis Laboratoire départemental d'analyses de la Drôme, Valence, France  
  • Evaluation of SampleGenie™ for Environmental AnalysisLeochimica Laboratories, Zoppola, Italy 
  • Evaluation of the Rocket and SampleGenie for Pesticide AnalysisLaboratoire départemental d'analyses de la Drôme, Valence, France

Natural Products Research

Natural products are researched for many reasons, from biodiversity preservation through flavour or fragrance research, to finding a cure for disease.  Whatever your reason, Genevac systems are used by researchers who are investigating the properties of the natural environment. 

For basic botanical and biological research, the miVac concentrator range are the mainstay for those extracting and purifying DNA or proteins for genome and proteome research.

Genevac systems are widely used by researchers seeking to extract functional molecules from natural sources.  A typical process would be to take a tissue (or micro-organism broth) sample and then perform a primary solvent extraction resulting in a large volume of crude extract.  The crude extract is often concentrated, for which the Rocket Evaporator is ideal, before being fractionated to isolate each component.  Fractionation may use a system such at the Sepbox, one, or two dimensional chromatography which produces many samples from one extract.  These samples need to be evaporated before storage or analysis and may require lyophilisation. Genevac HT series evaporators are used for this purpose. 

Useful Papers:

  • High Throughput Natural Product Discovery - a paper by Stephen Pickrahn, IFF 
  • Rapid Evaporation Processes to Enhance Natural Product Extraction - by Dr John Hester, Principal R&D Engineer – Natural Product Repository Supervisor, University of Mississippi

Post Purification Sample Handling

Depending on the process, and therefore the nature of the samples, then Genevac provides a number of solutions to facilitate post purification sample handling, including reformatting.

  • Normal Phase HPLC, SFC or Flash chromatography – removal of organic solvents is simple in a Genevac evaporator. Evaporation of Solvent Mixtures is safe when using Dri-Pure which eliminates the effects of bumping.
  • Reverse Phase HPLC– evaporation of water and acetonitrile (or methanol) is the principal application of many Genevac systems.  A multiple stage method has been developed to remove the organic solvent without freezing the water, remove the water, and then dry any remaining stubborn solvent.  Alternatively, the LyoSpeed fast lyopilisation method can be used in Genevac HT series evaporators.  Recent advances in condenser technology, in particular the high power -75°C cold trap available with the HT-8 or HT-12, have lead to significant advances in lyophilisation success rates.

Post Purification Handling following removal of purification solvents the sample typically needs to be reformatting from the fraction tubes or flask, into a small vial for compound storage. Genevac developed SampleGenie to enable a large volume to be dried (or lyophilised) directly into a small storage vial which eliminates the need to reformat samples from a flask or multiple tubes into a vial.

Depending on the number and nature of samples then one of several Genevac systems may be suitable – the EZ-2 and HT series are designed for working with smaller samples in plates, tubes and vials.  When working with large volumes in flasks – then the Rocket evaporator is the most suitable, taking up to 6 flasks.

Useful Papers: 
  • Drying HPLC Fractions - applications note 
  • Fast Lyophilisation for HPLC Fractions - Dr Induka Abeysena & Rob Darrington  
  • Enhanced LyoSpeed™ with a -75°C Condenser - Rob Darrington 
  • Integration for High Throughput HPLC Purification - Paul de Fraine, Syngenta & Dr Mike Jones 
  • Drying Solvent Mixtures - applications note 
  • Evaluation of the Rocket Evaporation System - paper by Christine Prosser et al., UCB
  • Automation of reverse phase HPLC fraction pooling, evaporation, and reformatting
Contact us if you are interested in any of the above papers

Oils, Fuels and Fats

Working with oils, fuels and fats can be difficult.  Whether extracting & recovering additives, evaluating lipid content of foods, characterising reclaimed cooking oils before reprocessing or conversion to biofuels, or investigating drillling test samples - oils can be difficult to dry in turn leading to problems with the analytical instrumentation.   

Extraction and separation techniques, be they basic dialysis, Dionex ASE or Counter Current Chromatography, all normally present the sample in a solution of organic solvent.  The sample typcially must be dried or concentrated before analysis.  Drying all the solvent can be difficult without using very high temperatures or other harsh regimens which may lead to loss of more volatile fractions within the oil.  For many such applications, researchers have found that the EZ-2 and the Rocket Evaporator have delivered significant enhancement to their recovery and results.  When working with larger solvent volumes, additional benefit is gained by way of  productivity savings when used with SampleGenie which enables large volumes to be concentrated or dried directly into a small vial.

Labtech Nitrogen evaporators or nitrogen blowdown concentrators

Nitrogen Concentrators


Labtech’s range covers systems from 6 tubes up to 54

Concentrators ( nitrogen evaporators or nitrogen blowdown concentrators) are a valid alternative to rotary evaporation mainly in case of small volumes (under 50 mL) and a large quantity of samples.

Broschure

Safety, productivity, flexibility and reliability

Concentrators accelerate the evaporation by decreasing the partial vapor pressure of the solvent just above the surface of the liquid. Blowdown evaporators use a jet of gas to continually force off the layer of air that is saturated with vapor. By immediately removing molecules that enter the vapor state, the molecules do not have a chance to return to the liquid, which increases the evaporation rate. As said blowdown technique is very useful for small sample volumes because with larger samples nitrogen blowdown will take longer and semi-volatile compounds may be lost. Since the samples are immersed in a water bath, with programmable temperatures up to 100°C, the evaporation is further accelerated. LabTech offers 4 models, 3 of them automated and one manual, hosting different tube sizes to satisfy multiple needs.

  • ● MultiVap 54 - automatic

  • ● MultiVap 8 - automatic

  • ● MultiVap 10 - automatic

  • ● MultiVap 6 - manual

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

MultiVap 54

The MultiVap 54 is the latest multi-channel and multifunctional parallel instrument designed by LabTech, including all accessories and functions to ensure the highest standard of effi ciency, speed, reliability, throughput and safety of any concentration process. Nitrogen sweeping, needle level adjustment and visible concentration process are only few of the advantages offered by the MultiVap 54.

Video MultiVap 54

MultiVap 10

The new LabTech MultiVap 10 automatic parallel system increases the capacity by 25% in comparison to the MultiVap 8 boosting the lab throughput. The price/performance ratio has further increased. With this system it is possible to evaporate to solid state or concentrate into a fixed end-point volume. A compact solution compared to conventional rotary evaporators, with the possibility to be used outside the fume hood thanks to the integrated vapor evacuation system.

MultiVap 8

The LabTech MultiVap 8 system increases the capacity and sample throughput in laboratories and maintains quality and low cost. With this system it is possible to evaporate to solid state or concentrate into a fixed end-point volume. A compact solution compared to conventional rotary evaporators, with the possibility to be used outside the fume hood thanks to the integrated vapor evacuation system.

Video MultiVap 8

MultiVap 6

The MultiVap 6 is a basic, cost effective sample preparation instrument featuring 6 independent channels. Without transferring, samples are directly concentrated in the vial thereby reducing the risk of transfer loss, improving recovery and saving precious time. The nitrogen fl ow rate of each channel can be adjusted independently as well as the needles that can be adjusted up and down. The aluminum alloy heating block guarantees temperature uniformity for all samples.

9 good reasons to choose LabTech Concentrators

  • ●  Advanced solutions and features

    Enhanced productivity

  • ●  Vortex nitrogen purge

    Provides high speed evaporation

  • ●  10, 50 & 200 mL concentration cups can be accommodated

    Flexible and time saving

  • ●  Automatic adjustment of nitrogen needle according to the sample volume reduction

    Precision, repeatability and gas saving

  • ●  Sample cups do not need to be handled

    Time saving and error proof

  • ● Cups can go directly to the liquid handler of GPC/SPE

    Time saving

  • ● Visible concentration process

    Peace of mind

  • ●  Automatic detection of the liquid endpoint

    Error proof and unattended operations

  • ● Excellent price/performance ratio

    A solution for any budget

From Micro to Large Capacity High-speed

Centrifuges


Labtech’s range virtually satisfies the needs of any modern lab with its 14 models divided in 4 families

Covering low and high speed, ventilated and refrigerated, small and large capacity, bench top and floor standing models supported by and incredible array of accessories that provide flexibility and versatility.

Centrifuge Overview

Best by design, quality and flexibility

When the Dutch physicist Christiaan Huygens coined for the first time the term “centrifugal force” in his DeVi Centrifuga published in 1659 he could not imagine what an innovation he brought into the scientific world. Lot of time has passed since then with a succession of discoveries and improvements such as the Nobel Prize awarded to Theodore Svedberg for the invention of the ultracentrifuge (some 900.000 xg!) in 1926 or the first floor standing unit with refrigeration introduced by Ivan Sorvall in 1955. It is even thanks to those pioneers that nowadays laboratory centrifuges are crucial instruments in countless applications from genetic engineering to hematology, from drug discovery to pathology, from marine science to agriculture, and you name it.

  • ● Micro Centrifuges

    3 compact units designed to offer maximum performance

  • ● Low-Speed, Clinical Centrifuges

    3 compact, robust and versatile low-speed models

  • ● Large Capacity, High-Speed Centrifuges

    3 multi-purpose, large capacity, either bench top and floor-standing, centrifuges

  • ● Multi-Purpose, High-Speed Centrifuges

    5 high-speed and versatile centrifuges that share rotors, buckets and accessories

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Micro Centrifuges

3 compact units designed to offer maximum performance in a small footprint for every workstation up to 27.237 xg, either refrigerated and ventilated, carrying popular microtubes.

Product Guide Microcentrifuges

Large Capacity, High-Speed Centrifuges

3 multi-purpose, large capacity, either bench top and floor-standing, centrifuges including the top-of-the-range model that can process samples up to 54.111 xg.
Max capacity 4x750 mL or 8 x 400 mL blood bags swing out and 6x500 mL fixed angle.

Product Guide Large Capacity High-Speed Centrifuges

Low-Speed, Clinical Centrifuges

3 compact, robust and versatile low-speed models, either ventilated and refrigerated, well suited for routine work reaching up to 3960 xg.
Max capacity 4x100 mL and 6x50 mL fixed angle.

Product Guide Low-Speed Clinical Centrifuges

Multi-Purpose, High-Speed Centrifuges

5 high-speed and versatile centrifuges that share rotors, buckets and accessories so as to offer a cost-efficient solution and save precious bench space. Speed ranges from 12.000 to 15.000 rpm generating rcf values from 16.582 to 25.910.
Max capacity 4x750 mL swing out and 6x250 mL fixed angle.

Product Guide Multi-Purpose High-Speed Centrifuges

Product Guide Multi-Purpose Table-top Centrifuge

9 good reasons to choose LabTech Centrifuges

  • ●  Fast cooling

    Cooling down to 4℃ from room temperature within only 5 minutes saves time

  • ●  Up to 100 (or 10) program memory

    Errors avoided and protocols maintained

  • ●  Motorized lid mechanism

    Safety and convenience

  • ●  Rotor ID

    Automatic rotor identification for safe operation

  • ●  Automatic lid release

    Speed and safety

  • ●  Large assortment of rotors, buckets and adaptors

    Extreme flexibility and investment reduction

  • ● User ID and password function

    Ideal for multi-user labs

  • ●  Automatic RPM/RCF conversion

    Easy detection of g-value delivered to samples means quality

  • ● Excellent price/performance ratio

    A solution for any budget

World's first Purge and Trap tool for CTC PAL autosamplers

CDS 7000C


World's first Purge and Trap tool for CTC PAL autosamplers

The 7000C delivers the same combination of quality that made the 7000E such a reliable instrument, but with plug and play connectivity to the worlds leading autosampler platform - the CTC PAL Robotic systems.

Brochure CDS

Broschure CTC

System description

The 7000C features our industry standard foam sensor, a newly designed wet trap and our distinguished exchangeable sample pneumatics systems, all providing the highest available performance and unrivaled chromotographic resolution.

  • ● Valve Oven Reaching as High as 350 °C

  • ● Silconert 2000 Coated Sample Pathway

  • ● Plug and Play Connectivity with CTC PAL

  • ● Hydroguard Wet Trap

  • ● Quick Access Panel

  • ● Patented Foam Sensor

  • ● Compatible with 5 ml and 25 ml Sparge Vessels

  • ● Optional Heated Sparge Vessel

  • ● Acquisition Software with Boosted Productivity

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Main Features

Valve Oven Reaching as High as 350 °C

This industries highest programmable valve oven expands the capability from VOC's defined in EPA 8260 into the sVOC range

Silconert 2000 Coated Sample Pathway

With the best chemically innert coating, 7000C offers a peace of mind in dealing even the most concentrated polar samples

Plug and Play Connectivity with CTC PAL

The plug and play setup for the 7000C with CTC PAL autosampler is quickly adding Purge and Trap capability to your system.

Hydroguard Wet Trap

The newly designed wet trap is coated with Hydroguard for optimized moisture control with maximized life span

Quick Access Panel

The quick access panel offers a convenient way to maintain the sample pathway to minimize any service downtime

Patented Foam Sensor

This patented sensor eliminates the possibility of sample foaming and subsequent contamination of the sample path way.

Compatible with 5 ml and 25 ml Sparge Vessels

The 7000C is capable of handling both 5 ml and 25 ml sample volume, depending on the sensitivity requirement of your analysis

Optional Heated Sparge Vessel

The heated sparge vessel adds two folds of value to the system; purging at an elevated temperature to improve sensitivity, and reducing carryovers to help keep the sample path way clean.

Acquisition Software with Boosted Productivity

The 7000C Purge and Trap plugin is seamlessly integrated to the CTC control software and method editor. 

Optional Internal Standard Module

This optional module comes with two independent 5 ml reservoirs for an delivery of 2 µl internal standard and/or surrogate to the sample.

Optional Hot Water Rinse Module

The hot water rinse module is designed to rinse the sample path way in both the CTC PAL and 7000C system to reduce carryover.

Optional Dynamic Headspace Module

The 7000C Dynamic Headspace Module has a maximum temperature of 300 °C with user settable needle height. A sample stirring mechanism could be activated at user-selectable speed in compliance with 8260 soil method.

CDS's reliable Purge and Trap concentrator

CDS 7000E


CDS's reliable Purge and Trap concentrator

The CDS-7000E was acknowledged as a workhorse in the industry for decades as the most cost effective Purge and Trap concentrator.

Brochure

System description

The 7000 E features our patented foam sensor, a newly redesigned wet trap for moisture control, and our original exchangeable sample pneumatics system, all providing the highest available performance and unrivalled chromatographic resolution.

  • ● Valve Oven Reaching as High as 350 °C

  • ● Silconert 2000 Coated Sample Pathway

  • ● Optional Soil Transfer Line

  • ● Hydroguard Wet Trap

  • ● Quick Access Panel

  • ● Patented Foam Sensor

  • ● Compatible with 5 ml and 25 ml Sparge Vessels

  • ● Powerful and User-Friendly PC Interface

  • ● Optional Electronic Programmable Flow Control

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Main Features

Valve Oven Reaching as High as 350 °C

This industries highest programmable valve oven expands the capability from VOC's defined in EPA 8260 into the sVOC range

Silconert 2000 Coated Sample Pathway

With the best chemically innert coating, 7000 E offers a peace of mind in dealing even the most concentrated polar samples

Optional Soil Transfer Line

7000E comes with standard sample transfer line to interface with any GC system. The optional soil transfer line is available to expand the 7000E to be a concentrator for headspace

Hydroguard Wet Trap

The newly designed wet trap is coated with Hydroguard for optimized moisture control with maximized life span

Quick Access Panel

The quick access panel offers a convenient way to maintain the sample pathway to minimize any service downtime

Patented Foam Sensor

This patented sensor eliminates the possibility of sample foaming and subsequent contamination of the sample path way.

Compatible with 5 ml and 25 ml Sparge Vessels

The 7000E is capable of handling both 5 ml and 25 ml sample volume, depending on the sensitivity requirement of your analysis

Powerful and User-Friendly PC Interface

The powerful windows based software gives full access on the purge and trap parameter settings.

Optional Electronic Programmable Flow Control

With the electronic flow controller, the gas flow rate could be individually set within different purge and trap steps. For example, the flow rate could be increased in bake mode to improve GC resolution while maintaining a different flow rate in purge mode.

CDS's 2nd generation Purge and Trap autosampler for both water and soil samples

CDS 7450


CDS's 2nd generation Purge and Trap autosampler for both water and soil samples.

The 7450 autosampler is a 72 position autosampler with dynamic headspace sampling function for EPA methods 524, 624 and 8260 (both water and soil), and built on our 2nd generation autosampler with a more precise handling for sample loading.

Brochure

System description

A perfect match for the 7000E Purge & Trap concentrator.

  • ● 72 Position Autosampler

  • ● Internal Standard Addition

  • ● 5 mL and 25 mL Sample Loop

  • ● Dynamic Headspace

  • ● Water station

  • ● Magnetic stirrer

  • ● PEEK Sample Pathway

  • ● Powerfull PC interface

  • ● Gripper with Optical Sensor

  • ● Precision Robotic Arm

  • ● Ease of Alignment

  • ● Longer Life Expectancy

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Main Features

72 Position Autosampler

The autosampler comes with a high capacity of 72 positions for 40 ml VOC vials in three separated racks.

Internal Standard Addition

The autosampler is equipped with a 5 ml reservoir for internal standard addition.

5 mL and 25 mL Sample Loop

Depending on the sample size from the Purge and Trap concentrator, the autosampler could accommodate both 5 mL (default) and 25 mL (optional) sample transfer.

Dynamic Headspace

The 7450 is equipped with a soil tower for dynamic headspace sampling in compliance with EPA 8260 soil samples.

Water station

The soil tower is equipped with a water station to process water samples, and a separate needle is used for soil samples to prevent carry over.

Magnetic stirrer

The magnetic stirrer drives the magnetic bar in the soil vial based on EPA 5030 and 5035 sampling requirement for soil samples.

PEEK Sample Pathway

The chemically inert sample pathway guarantees the success of your purge and trap testing even with challenging liquid samples

Powerful PC Interface

The PC software has a friendly interface to configure each run with programmable rinses, programmable blanks, internal standard addition, and water addition to soil sample.

Gripper with Optical Sensor

The highly reliable VOC vial gripper has an optical sensor as a safety measurement to give you peace of mind when transferring samples to the soil tower.

Precision Robotic Arm

The position accuracy of the 2nd generation autosampler is improved by 50% to 1 mm (X, Y and Z) 3D placement accuracy due to a high precision drive mechanism

Ease of Alignment

The alignment calibration has been significantly improved in the 2nd generation autosampler. The user friendly software tool helps to make alignment calibration in under 10 minutes.

Longer Life Expectancy

The 2nd generation autosampler comes with a SMART acceleration control to lower the impact on the driving mechanism by 40%. This extends the life of the system due to less strains.

CDS's 2nd generation Purge and Trap autosampler (water only) with improved precision

CDS 7350


CDS's 2nd generation Purge and Trap autosampler (water only) with improved precision

The 7350 autosampler is a competitively priced, 72 position autosampler for EPA methods 524, 624 and 8260 waters, and built on our 2nd generation autosampler with a more precise handling for sample loading.

Brochure

System description

A perfect match for the 7000E Purge & Trap concentrator.

  • ● 72 Position Autosampler

  • ● Internal Standard Addition

  • ● 5 mL and 25 mL Sample Loop

  • ● Precision Robotic Arm

  • ● Ease of Alignement

  • ● Longer Life Expectancy

  • ● PEEK Sample Pathway

  • ● Powerful and User-Friendly PC Interface

  • ● Multiple Aliquots

Product Specialist

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.
031-709 8186

Main Features

72 Position Autosampler

The autosampler comes with a high capacity of 72 positions for 40 ml VOC vials in three separated racks.

Internal Standard Addition

The autosampler is equipped with a 5 ml reservoir for internal standard addition.

5 mL and 25 mL Sample Loop

Depending on the sample size from the Purge and Trap concentrator, the autosampler could accommodate both 5 mL (default) and 25 mL (optional) sample transfer.

Precision Robotic Arm

The position accuracy of the 2nd generation autosampler is improved by 50% to 1 mm (X, Y and Z) 3D placement accuracy due to a high precision drive mechanism

Ease of Alignment

The alignment calibration has been significantly improved in the 2nd generation autosampler. The user friendly software tool helps to make alignment calibration in under 10 minutes.

Longer Life Expectancy

The 2nd generation autosampler comes with a SMART acceleration control to lower the impact on the driving mechanism by 40%. This extends the life of the system due to less strains.

PEEK Sample Pathway

The chemically inert sample pathway guarantees the success of your purge and trap testing even with challenging liquid samples

Powerful PC Interface

The PC software has a friendly interface to configure each run with programmable rinses, programmable blanks, internal standard addition, and water addition to soil sample.

Multiple Aliquots

The sampling double-jacketed needle could be configured to reach the bottom of the VOC vial to perform multiple aliquots runs from the same sample

KOVALENTS PHILOSOPHY

At Kovalent we strive to establish and develop long-term partnerships with our customers. When we use the word “partnership” we mean that Kovalent becomes an integral part of our customers’ projects, where we are expected to fully understand their application needs. We aim to make Kovalent our customers’ first and natural choice, and this ambition permeates our entire organisation from initial contact to finished and delivered product.

CONTACTS:

Kovalent AB
Hulda Lindgrens gata 6A
421 31 VÄSTRA FRÖLUNDA
Sweden
Phone: +46(0)31-709 81 80
This email address is being protected from spambots. You need JavaScript enabled to view it.
Org.nr: 556417-2194

SKANDINAVISKA GENETEC AB

Genetec is a member of the same family of companies as Kovalent. Both companies share the same set of values and are in many ways integrated with each other. The main difference between the two companies are their products. Kovalent is involved in system solutions including instrumentation and Genetec is mainly working with consumables. The focus of Genetec is chromatography accessories. You are welcome to visit their state of the art web shop: genetec.se