The ETHOS LEAN collects Milestone experience and embraces all these values into a compact and economical solutions for sample preparation, matching the requirements of laboratories that approach microwave digestion without the needs of high-volume labs.

The ETHOS LEAN was specifically designed to provide high-quality closed-vessel acid digestion for labs with limited throughput needs. Whether you're setting up a new lab, or improving your elemental analysis, a compact and economical solution for sample preparation is crucial. ETHOS LEAN matches the requirements of laboratories that approach microwave digestion without the needs of high-volume labs.

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

Easy to use and to implement are pivotal ingredients that defines the ETHOS LEAN. From the rotor's ease-of-use to the smart software, the ETHOS LEAN is the plug and play solution for your lab to quickly get up-and-running. The comprehensive Milestone Validation Package further boost the system implementation, enabling to match GMP guidelines' requirements. The ETHOS LEAN user centric design makes it an essential and reliable tool for elemental analysis, even right after its installation.

The easyTEMP technology controls the digestion temperature in all vessels, while the easyCONTROL software provides a large methods library to handle your samples, eliminating the tedious method development. The software, fully compliant with CFR 21 part 11, includes the most advances features to simplify the control of the digestion process.

The ETHOS LEAN takes almost half of the conventional microwave footprint. The reliability and quality of the components and materials used, along with unique Milestone know-how in microwave sample preparation makes the ETHOS LEAN a great investment even for whom approach microwave digestion for the fi rst time but chase the best-in-class technology.

The easyTEMP technology controls the digestion temperature in all vessels, while the easyCONTROL software provides a large methods library to handle your samples, eliminating the tedious method development. The software, fully compliant with CFR 21 part 11, includes the most advances features to simplify the control of the digestion process.

The MAXI-14 rotor features 14 with high-purity PTFE-TFM vessels and robust shield to achieve high temperature and pressure. The unique vessels constructions simplify the rotor handling with fast and trouble-free vessels assembly. Safety is ensured in every vessel through the vent-and-reseal technology, invented and patented by Milestone, that acts as individual pressure release mechanism. The rotor operates in perfect synergy with easyTEMP sensor and easyCONTROL software to ensure complete and safe digestions of a wide array of matrices, such as organic and environmental samples in compliance with US EPA methods.

The easyTEMP contactless sensor directly controls the temperature of all samples and solutions, providing accurate temperature feedback to ensure complete digestion in all vessels with superior safety. This technology combines the fast and accurate reading of an in-situ temperature sensor with the flexibility of an infrared sensor.
In combination with our 'vent-and-reseal' vessel technology, easyTEMP direct contactless sensor ensures complete and safe digestions without any loss of volatile compounds.

easyCONTROL software: built-in application library

Digestion profile of Fish sample with 5 mL of HNO3

easyCONTROL software. Detailed information on the specific application

Typical digestion profile in accordance with US EPA 3051A

Hundreds of applications, including all US EPA methods, are preloaded in the ETHOS LEAN terminal, virtually eliminating any need for method development. To further simplify the workflow in the lab the ETHOS LEAN is equipped with a backlit logo that indicates the actual status of the digestion process.

The MAXI-14 rotor offers a wide range of application capabilities. Choose your typical application and watch your Virtual Demo Videos.

Cannabis

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Enviromental

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Pharmaceutical

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ETHOS EASY is the most advanced yet easy to use microwave digestion platform we have ever manufactured. It offers a perfect integration between microwave hardware, user interface, digestion sensors and pressure vessels.

The range of sample types requesting microwave digester and analysis for trace metals has grown significantly in recent years. At the same time, sample workloads have increased, and turnaround time reduced.
In addition, the development of collision cell ICP-MS has widened its applicability to more complex sample types placing additional demands on microwave acid digestion: its lower detection limits and fast analysis time require lower blank contribution and higher throughput in sample preparation techniques.
In response to these demands, Milestone has developed the new microwave digestion oven ETHOS EASY, specifically designed for closed vessel microwave acid digestion, with full control of all reaction parameters.

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

While other manufacturers use molded plastic, Milestone uses 18/8 stainless steel construction throughout which creates the most durable, reliable, and safe microwave system available.

THE LARGEST STAINLESS-STEEL MICROWAVE CAVITY

THE MOST POWERFUL MICROWAVE DIGESTER

PRESSURE-RESPONSIVE DOOR FOR MAX SAFETY

In a digestion process, the temperature controls the sample decomposition and directly affects digestion quality. Milestone pioneered the use of infrared sensors combined with an in-situ temperature sensor. Today, Milestone innovates again by combining all the benefits of in-situ and infrared sensors into the Milestone easyTEMP, a direct contactless temperature sensor.

The easyTEMP contactless sensor directly controls the temperature of all samples and solutions, providing accurate temperature feedback to ensure complete digestion in all vessels with superior safety. This technology combines the fast and accurate reading of an in-situ temperature sensor with the flexibility of an infrared sensor.
The ETHOS UP software provides digestion history traceability and temperature measurement for every sample. Temperature diagrams and profiles are displayed in real-time, and can be saved on the ETHOS UP terminal.
In combination with our 'vent-and-reseal' vessel technology, these sensors ensure complete and safe digestions without any loss of volatile compounds.

Hundreds of applications including all US EPA methods, are preloaded in the Ethos Easy terminal virtually eliminating any need for method development. To further simplify the workflow in the lab the Ethos Up is equipped with a backlit logo that indicate the actual status of the digestion process.

The new ETHOS UP is simply the most advanced yet easy to use system for microwave sample preparation we have ever manufactured. It offers a perfect integration between microwave hardware, user interface, digestion sensors and pressure vessels.

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

While other manufacturers use molded plastic, Milestone uses 18/8 stainless steel construction throughout which creates the most durable, reliable, and safe microwave system available.

THE LARGEST STAINLESS-STEEL MICROWAVE CAVITY

THE MOST POWERFUL MICROWAVE DIGESTER

PRESSURE-RESPONSIVE DOOR FOR MAX SAFETY

LIVE MONITORING WITH MILESTONE SafeVIEW

In a digestion process, the temperature controls the sample decomposition and directly affects digestion quality. Milestone pioneered the use of infrared sensors combined with an in-situ temperature sensor. Today, Milestone innovates again by combining all the benefits of in-situ and infrared sensors into the Milestone easyTEMP, a direct contactless temperature sensor.

The easyTEMP contactless sensor directly controls the temperature of all samples and solutions, providing accurate temperature feedback to ensure complete digestion in all vessels with superior safety. This technology combines the fast and accurate reading of an in-situ temperature sensor with the flexibility of an infrared sensor.
The ETHOS UP software provides digestion history traceability and temperature measurement for every sample. Temperature diagrams and profiles are displayed in real-time, and can be saved on the ETHOS UP terminal.
In combination with our 'vent-and-reseal' vessel technology, these sensors ensure complete and safe digestions without any loss of volatile compounds.

The Ethos Up comes with a touch screen terminal with easyCONTROL software which provides full control of all digestion parameters, complete documentation and improves the overall procedure. Hundreds of applications including all US EPA methods, are preloaded in the Ethos Up terminal virtually eliminating any need for method development. To further simplify the workflow in the lab the Ethos Up is equipped with a backlit logo that indicate the actual status of the digestion process.

The ultraWAVE fully endorses our vision in microwave sample preparation: it has already revolutionized and enhanced the way analytical chemists think to sample preparation for trace metal analysis in hundreds of laboratories all over the world.

The ultraWAVE is based on the SRC (Single Reaction Chamber technology), invented by Milestone several years ago (Patents pending). SRC technology achieves extraordinary performance capabilities combining microwave heating with a high-pressure reactor which acts simultaneously as microwave cavity and vessel. The ultraWAVE chamber is sealed, pressurized, heated, cooled, vented, and opened via a dedicated touch-screen control terminal. Loading a rack of samples into the chamber is the only manual operation in an otherwise fully automated process of microwave-assisted sample preparation. The outer surfaces of the vessel remain at room temperature throughout the entire microwave heating cycle. As a result, the ultraWAVE is dramatically less labor intensive and easier to use compared to conventional microwave digestion systems.

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

For optimized workflow

1. Loading

2. Closing and pressurizing

2. Heating and cooling

4. Pressure release and opening

 The ultraWAVE rack configurations include 4, 5, 8, 15, 19, 22 and 26 position and combinations thereof. Vials are available in TFM, quartz or disposable glass, and are fitted with loose TFM caps to ensure pressure equalization. Unlike conventional microwave digestion systems, no vessel assembly or disassembly is required. The use of disposable glass vials eliminates the cleaning step, further enhancing the lab’s workflow. The fast assembly of the vials, the automatic closing and opening cut the handling time, reducing the labour cost up to 50%.

Like all Milestone products, the ultraWAVE has been designed with operator safety of paramount importance: it has been developed for being used with any acid or combination thereof, and every single reactor is tested at a pressure up to 330 bar. A thick acrylic shield surrounds the working area, and runs cannot be started unless the chamber clamps are in correct position. Temperature and pressure are monitored 20 times/sec, automatically adjusting microwave power to control even highly exothermic reactions.

The benefits of SRC technology

Any combination of sample types (food, environmental, polymer, cosmetic, pharmaceutical, geological, chemical, and petrochemical) can be digested simultaneously; no need to batch samples into identical types. No method development is needed, as the same method can be used for nearly any sample. And for the first time, blanks and reference standards of any matrix can be digested alongside samples, enabling true in-run digestion quality control.

Operating up to 199 bar pressure and 300°C temperature, the ultraWAVE enables the complete digestion of extremely difficult samples and of large amounts of organics, outperforming any other microwave digestion system. Unlike conventional microwave digestion systems, every sample is under direct temperature and pressure control, so there is no need to rely on a reference vessel or to an indirect control such as infrared temperature sensors.
The ultraWAVE reaches high temperatures faster, cools faster (10 minutes from 200°C to room temperature), and is capable of higher pressure and temperature than any other system. The ultraWAVE does not suffer of any cross contamination among samples. Blanks are significantly lower than with conventional microwaves, since less acid is used and vials have a much less surface in contact with the analytical solution.

High Productivity

Typical sample turnaround time (number of samples in 8 hours).

The ultraWAVE accommodates inexpensive disposable vials.

Opening and closing the vessels, assembly and disassembly of the rotors are not required in the ultraWAVE anymore. The handling of the system is dramatically reduced, and tedious and time-consuming procedures are eliminated.
The technology used in all conventional microwave lead to create stressful conditions in the TFM vessels, substantially reducing their lifetime. The design of SRC technology in the ultraWAVE strongly contributes to the reduction of the running costs by using inexpensive and handy vials suitable for any metals and trace metals determination.

The ultraWAVE is controlled via a compact external terminal with an easy-to-read, bright, full-color, touchscreen display. Multiple USB and Ethernet ports are provided, for interfacing the instrument to external devices and to the local laboratory network. The terminal runs the Milestone easyWAVE, a completely new user-friendly, icon-driven, and multi-language software. Just recall a previously stored method or create a new one; press the Start icon and the system will automatically follow the user defined temperature profile using a sophisticated PID algorithm.
Hundreds of applications, including all US EPA methods, are preloaded, eliminating any need for method development.

The Milestone Validation Packages include several protocols in order to fulfill regulatory requirements, such as the Good Manufacturing Practice (GMP) guidelines that, along with our superior support and expertise, will be by your side throughout the whole process. Our experts will support you with the right confi guration, with a dedicated procedure for your samples, with a demonstration of the system’s capabilities and with a complete validation package that includes: DQ (Design Qualification), IQ (Installation Qualification), OQ (Operational Qualification), PQ (Performance Qualification) and the requalification. All the tests carried out by our service engineers are guaranteed by certified test equipment, providing high accuracy and meeting all the regulatory requirements. Our software is fully compliant with the FDA regulation 21 CFR part 11, with an exhaustive audit trail for complete traceability. The MVP is one of the multiple services offered by Milestone to ensure the highest industry standards in customer support.

The patented Milestone ultraCLAVE achieves extraordinary performance capabilities by combining SRC patented technology with the highest throughput available in the market.

The ultraCLAVE's utilization of SRC technology allows for the processing of mixed matrices in the same run with different chemistries and to use vials/racks instead of vessels/rotors, which essentially removes the handling step in sample preparation. The ultraCLAVE completely changes the rules in microwave sample preparation and sets new standards in digestion, enhancing the overall efficiency in elemental analysis. The ultraCLAVE is capable of running as many as 77 samples simultaneously at high temperature up to 300 °C and pressure up to 200 bar, thus enhancing lab efficiency.

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

The patented Milestone ultraCLAVE achieves extraordinary performance capabilities by combining direct microwave heating in a high pressure reactor, which acts simultaneously as microwave cavity and vessel. Microwave energy is introduced into the reactor through a unique microwave port. This focused-multimode cavity design ensures maximum sample heating efficiency. Heat generated in the reactor is removed by a re-circulating cooling system, and the stainless steel vessel remains at approximately room temperature throughout the entire heating cycle.
The ultraCLAVE is designed for simplicity of use. Loading a rack of samples into the chamber is the only manual operation required. The reaction chamber is sealed, pressurized, heated, cooled, vented, and opened all under computer control.
The system dramatically reduces the labor compared to conventional microwave systems.

Sample preparation is the most labor-intensive step in elemental analysis, as it requires assembling, closing, opening and disassembling of the vessels. These operations involve a lot of handling, which is directly affected by the number of vessels used. The ultraCLAVE with SRC technology, uses vials and racks instead of rotors and vessels, completely removing laborious handling. SRC technology is based on a stainless-steel reactor with a volume in excess of 4 L, which act as both a microwave cavity and digestion vessel. A 3.5 L PTFE vessel with a base load is introduced into the stainless-steel reactor. The operator places the samples and acids into vials with loose-fitting caps, places the rack in the ultraCLAVE and the digestion process begins (Step 1). By pressing “START” on the dedicated large screen terminal, the system automatically closes the stainless-steel vessel and clamps, loads the nitrogen pressure and runs the pre-selected microwave program (Step 2). After completion the vials are cooled using a powerful external chiller, pressure is safely released, and the main reactor opens, delivering the digested solutions ready for dilution and analysis (Step 3).

1. Rack loading

2. MW heating

3. Opening

The combination of stainless-steel reactor with microwave technology results in a digestion system with superb performance and abilities. The temperature range up to 300 °C allows for the digestion of virtually any sample, while the maximum pressure of up to 200 bar allows for digesting very large sample amounts. Highly reactive samples such as large amounts of food, pharmaceuticals, polymers and petrochemicals can be completely digested. Furthermore, the platform's flexibility found a natural fit in other analytical testing labs such as environmental, clinical and biological. The ultraCLAVE allows for the simultaneous digestion of completely different matrices with different chemistries, as the set conditions in the stainless-steel cavity are applied to all vials, ensuring complete digestion of all samples in the reaction chamber.

SRC technology offers high throughput without compromising productivity. The ultraCLAVE greatly reduces handling and operator time, eliminates the need to batch the samples and to clean of vials, resulting in a more productive approach to digestion across multiple industries. Most samples will be digested using a single program, eliminating method development and simplifying the digestion procedure. The ultraCLAVE is an efficient tool for mixed or similar samples. Lab throughput is greatly enhanced, with a digestion cycle taking about 60 minutes for 40 or 77 samples. Lab efficiency is improved by removing the need to batch samples, speeding up the digestion cycle and using inexpensive consumables. The ultraCLAVE offers superior productivity, ease of use and performance far surpassing any conventional digestion system.

Racks and vials with loose-fitting caps greatly simplify daily operation and reduces running costs. The ultraCLAVE racks are available in several configurations, from 6 to 77 individual samples, to accommodate varying sample throughput needs as well as large sample masses. The selection of vials includes high-purity PTFE, quartz and disposable glass. The use of disposable glass vials eliminates the tedious and time-consuming cleaning step, improving lab workflow. Rack handling is as simple as hanging it in the system. Moreover, SRC technology allows for the use of a single method regardless of the sample type and amount, making it possible to digest different matrices together in the same run.

Discover our commitment new USP <232>/<233> and ICH Q3D
for Ensuring Safer Drugs for Providing High Quality API’s

New methods and guidelines from United States Pharmacopeia (USP) Chapters USP <232>, <233> and <2232> as well as guidelines from International Conference on Harmonization (ICH observed by the European Medicines Agency (referred as ICH Q3D) set new standards in laboratory analysis and sample preparation for pharmaceutical samples. Determination of elemental impurities in pharmaceutical products can be made from the sources like catalysts, raw materials, production processes, and packaging materials.
The implementation of the new USP chapters <232> and <233> on elemental impurities in January 2018 redefined analysis and sample preparation in pharmaceutical industry.
Milestone offers chemists a practical guidance for determining elemental impurities in pharmaceutical products and dietary supplements.

The SK-15, MAXI-44 and MAXI-24 HP digestion rotors feature unique Milestone MDR technology to control the inner pressure of all vessels in complete safety. This 'vent and reseal' technology for pressure release is the foundation of Milestone's leadership in microwave digestion.

The SK-15, MAXI-44 and MAXI-24 HP offers, high quality digestion, high sample throughput and high performance. A large selection of high purity quartz and TFM inserts are available for these rotors to work with smaller sample amounts or to minimize the dilution factor of analytical solution.
Our microwave digestion systems can be used with a wide range of rotors and accessories providing a flexible, versatile and productive platform for digestion and extraction processes, microwave synthesis, protein hydrolysis and vacuum evaporation. For example, our selection of extraction rotor with flagship fastEX-24 with disposable vessels can extract up to 30 grams of sample with minimum solvent volume.

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

HIGH-PRESSURE ROTOR

Regardless of the samples you’re trying to digest, the SK-15 High-pressure rotor is always an effective option to simplify your journey from sample to analysis, even with hard-to-digest samples, reactive samples or large sample masses. The SK-15 is a high-pressure and high-temperature rotor with a capacity of up to 15 PTFE-TFM vessels of 100 mL.

HIGH-TROUGHPUT ROTOR

Many laboratories routinely process high number of samples, such as soils, sediments and aqueous samples. The MAXI-44, featuring up to 44 PTFE-TFM vessels of 100 ml, perfectly matches these requirements, providing high productivity, reliability and superior ease of use. The MAXI-44 finds its natural fit in all laboratories requiring to process large samples batches.

HIGH-PERFORMANCE TROUGHPUT ROTOR

The MAXI-24 High Performance (HP) and high throughput rotor was designed with double pressure limits and greater capacity than other high throughput rotors. It process increased volumes of sample and a wide variety of matrices within a single rotor-based platform. Quick-assembly vessels are closed with a simple hand-tightening, improving your daily productivity.

With the comprehensive choice of rotors and accessories available, you can turn the ETHOS UP and ETHOS EASY into a versatile platform able to perform also solvent extraction, protein hydrolysis, vacuum evaporation and alkaline fusion.

fastEX-24

SK-12

MAXI-14

MMR-15

SK-10

Ultrafast

This configuration reduces the amount of acid required for digestion to near stoichiometric quantities, which reduces the dilution factor and improve the detection limit.

Patented "Vent-and-Reseal" Technology

All Milestone rotors feature an enhanced 'vent-and-reseal' technology for controlling the inner pressure of all vessels with complete safety. This patented (US Patent 5,270,010) technology provides the operator with unsurpassed safety and performance capabilities: highest temperature and pressure, highest safety standards, ease of use, and very fast cooling (180°C to 40°C in 10 minutes). While other systems use membranes or burst disks that render a vessel useless after venting, the Milestone system releases only the excess pressure from the vessel. This ensures that there is no stress to the door of the microwave system and no loss of sample as could happen in the

 case of a membrane or disk bursting. The illustration shows 'vent-and-reseal' in action: the vessel cap is held in place by a dome-shaped spring (1). In the case of over pressure due to a highly exothermic reaction, the spring is flattened, allowing the cap to lift up slightly (2) releasing excess pressure. Immediately the excess pressure is released, the spring reseals the vessel (3), and the digestion continues. There is no loss of sample and no clean up needed. The microwave program continues to completion and no re-run is required. While there are other methods of venting, only Milestone has 'vent-and-reseal' technology.

Self-regulated venting

There is another approach to venting, but it implies limitations compared to Milestone's Vent-and-Reseal and Self-regulating technology.

Burst disk