The fourth generation of the EZ-2 Series is the pinnacle of parallel evaporation that draws on the expertise of Genevac engineers and the experiences of many scientists in the laboratory
The fourth generation of the EZ-2 Series has been redesigned with features to achieve higher performance, more user-friendly, more versatile and with far less environmental impact. Operators can simply load, set, and walk away without need for any special training. The EZ-2 4.0 has also been redesigned to minimize its environmental impact, with low Global Warming Potential (GWP) refrigerant, a standby mode to help save energy, and reduced use of plastic throughout. The packaging is also recyclable.
Accelerating Breakthroughs In Life Science Research …
The EZ-2 4.0 ensures fast, easy, safe and environmentally-friendly removal of all commonly used solvents and acids. Advanced technologies - including our Dri-Pure® sample protection system which prevents cross-contamination and sample loss due to bumping - allow you to dry, concentrate, or lyophilize - to a 'fluffy' powder and even crystals - with total confidence.
Features:
● Touchscreen interface featuring more pre-set methods for frequently-used protocols ensures effortless "day-in, day-out" use
● Ergonomic redesign with the SpeedTrap™ jar at the front for easy visibility, and simple removal/replacement
● EXALT technology for crystallization studies such as polymorph screening for added versatility
● High power lamps and software improvements enhance overall performance
There are three models in the SP Genevac EZ-2 4.0 Series: Standard, Plus & Elite
● EZ-2 4.0 Standard is recommended for solvents with boiling points up to 120°C and ideal for evaporating volatiles
● EZ-2 4.0 Plus is recommended for solvents with boiling points up to 165°C and ideal for evaporating HPLC fractions
● EZ-2 4.0 Elite is recommended for solvents with boiling points up to 202°C and suitable for evaporating high boiling point solvents and lyophilize aqueous based samples
Evaporative sample preparation for forensic and diagnostic clinical tests must be performed scrupulously. Genevac systems are used by clinical biochemists and forensic scientists for a number of testing methodologies, such as vitamin D or K analysis, neonatal screening and forensic toxicology.
Mass Spectrometry (MS) is replacing radio-immunoassay (RIA) in Clinical biochemistry analysis, removing the need to use radioactive reagents. One of the Steroid assays performed by hospital clinical labs is for Vitamin D analysis where there is a need to identify the relative abundance of vitamin D2 and D3. Samples are typically extracted into Hexane, concentrated (e.g. using a miVac) and analysed by MS (avoiding ion suppression problems often seen with RIA).
Clinical and forensic toxicology investigations also utilise MS methodology, typically with solid phase extraction and evaporation as part of the sample preparation process. Blood and urine analysis can be utilised as part of a medico-legal investigation into drug-related deaths and drug-facilitated crimes and in the clinical assessment of alcohol/drug consumption. Hair analysis can also provide evidence over time of drug or alcohol abuse, as part of programme compliance for those participating in drug or alcohol dependency treatment or for workplace or health insurance screening. The EZ-2 has been used to streamline the sample preparation process whilst maintaining sample integrity and improving sensitivity.
Tandem MS is also used to identify metabolic disorders which include aminoacidemias, urea cycle disorders, organic acidurias, and fatty acid oxidation disorders. Samples can be presented as plasma, urine, and blood spots or urine on filter paper. Sample preparation techniques can include solvent extraction, acid derivitisation and evaporation prior to reconstitution in a suitable medium for injection to MS. Evaporation of butanolic HCl used for derivatisation using blowdown techniques results in corrosion of the system especially pins/needles/jets which can lead to contamination of samples and erroneous results. The EZ-2 with HCI resistance commonly used for these sample preparation stages. One example would be the test for CAT (carnitine acyl carnitine translocase deficiency) in neonates, an inborn error of metabolism. Lack of this enzyme prevents the body from converting fats into energy. Labs do the initial test on Guthrie cards (dried blood spots). The cards are punched and extracted with 200ul of Methanol. The supernatant is placed into microtitre plates and dried. Samples are then derivatised using approx 100ul 3N HCl in anhydrous Butanol and dried again. Finally, samples are re-suspended in Water & acetonitrile for analysis by MS.
miVac concentrators have been used by the Australian Sports Drug Testing Laboratory to improve the testing for synthetic insulin analogues in athletes' blood samples. Using the miVac's ability to control conditions during the concentration step the analyst has more confidence that they are seeing the true blood concentration of potential drugs of abuse in the athlete's sample.
Useful Papers:
Contact us if you are interested in any of the above papers
Useful Papers:
Contact us if you are interested in any of the above papers
At Kovalent we strive to establish and develop long-term partnerships with our customers. When we use the word “partnership” we mean that Kovalent becomes an integral part of our customers’ projects, where we are expected to fully understand their application needs. We aim to make Kovalent our customers’ first and natural choice, and this ambition permeates our entire organisation from initial contact to finished and delivered product.
Genetec is a member of the same family of companies as Kovalent. Both companies share the same set of values and are in many ways integrated with each other. The main difference between the two companies are their products. Kovalent is involved in system solutions including instrumentation and Genetec is mainly working with consumables. The focus of Genetec is chromatography accessories. You are welcome to visit their state of the art web shop: genetec.se