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Rocket Synergy

Space saving –one Rocket replaces several rotary evaporators

Space saving –one Rocket replaces several rotary evaporators

Designed to dry or concentrate up to six flasks, each containing a maximum of 450ml of solvent, or 18 ASE® vials, with no user intervention or attention

System description

The removable flask rotor may also be replaced with a 5 litre stainless steel vessel for batch processing
Rocket controls are very easy to use. Load your samples, select the correct method,press start and walk away. The evaporator is equipped with high performance features that prevent foaming, bumping and cross contamination. A built-in cold trap provides very high levels of solvent recovery, even with volatile organic solvents. Auto-draining, under the control of the Rocket, ensures optimal solvent recovery is maintained under all conditions.

Now you don't need to choose between flask or batch evaporation. The Rocket Synergy evaporator will accommodate your process, whatever the volume. Each is capable of replacing several rotary evaporators and saving valuable bench space.

Key features: High speed evaporation, High speed evaporation, Autostop, Unique Rocket low pressure steam heat transfer technology, DriPure anti bumping, Sample volumes from 50ml to 5 litres, Removable interchangeable rotors, Autodraining condenser, Strobe to view evaporation progress

  • ● Easy to use – simple controls and intelligent software
  • ● Fully automated from start to finish
  • ● Space saving –one Rocket replaces several rotary evaporators
  • ● Perfect results – no monitoring or intervention required for excellent sample recovery
  • ● Environmentally friendly cold traps and advanced methodology provide very high solvent recovery

Product Specialist

Mikael Alfredsson Kovalent

Mikael Alfredsson

"Our expert in Digestion, Extraction, Syntesis and Evaporation with more than 20 years experience in the field of sales and service. Contact me for if you have questions or need a quotation"

Application Examples

Parallel Chemistry

Genevac evaporators have been designed from the outset to be robust and withstand the rigors of working in the chemistry laboratory.  Systems were used in the early days for Combinatorial Chemistry where routine use of 100% TFA has given systems a tough field testing. 
Whether working in drug discovery, flavour or fragrence research, liquid chrystal synthesis or academic reaserch, Genevac systems are the ideal tool for use when performing parallel chemistry.  When working with a single sample then a rotary evaporator is ideal, whereas, when you have multiple samples this would be a bottleneck.  Spending time just watching a rotary evaporator is not very efficient!
  • The main uses for Genevac systems are:
  • ● Solvent exchange – removal of reaction solvents between stages
  • ● Re-salt formation – removal of strong acids of bases when changing salt forms.  Genevac have a special option for HCl resistance which enables the use of concentrated HCl – ideal for this purpose.
  • ● Post Purification Handling – removing purification solvents following normal phase, reverse phase or chiral separation. Genevac also offer SampleGenie to enable a large volume to be dried directly into a small storage which eliminates the need to reformat samples from a flask into a vial.  Reverse phase HPLC fractions may also be fast lyophilised in some Genevac systems.
  • ● Compound logistics - transfer to and management of samples in storage conditions and systems, this is often done using DMSO, a notoriously difficult to evaporate high boiling point solvent.
  • Depending on the number and nature of samples then one of several Genevac systems may be suitable – the EZ-2 and HT series are designed for working with smaller samples in plates, tubes and vials.  When working with large volumes in flasks – then the Rocket evaporator is the most suitable, taking up to 6 flasks.

Useful Papers:

  • Reactions involving HCl and their Evaporation - Dr Induka Abeysena, Genevac 
  • Development of an Evaporator for High Throughput Chemistry- Dr Tom Smith, GSK 
  • Surviving TFA - Application Note Parallel Dry-Loading of Synthesis Samples onto Silica for Analysis- Dr Nigel Vicker, Bath University Pharmacy Department  
  • Library Maintenance for the Smaller Pharma Company - poster by Dr Sally Hampton, Ferring Pharmaceuticals 
  • How to Evaporate High Boiling Point Solvents - Application Note

Contact us if you are interested in any of the above papers

Food & Beverage

Quality and safety testing of food and beverages is an area of growing importance, be that for exporters, importers or government bodies, accurate analytical results are critical.  In common with many other applications, careful sample preparation is critical, especially when the analyte of interest is volatile.

Genevac systems find application in a number of areas, from testing constituents of beverages such as Cognac or gluten levels in Whisky, to pesticide analysis of fruit and vegetables, antibiotic residues in meats or vitamin levels in cereals.  The research and development of Functional Foods where high quality scientific research is carried out also benefits from the speed and quality of a Genevac system.  The EZ-2 or Rocket are commonly used, often in conjunction with SampleGenie™, because this delivers automation of sample transfer and gives unparalleled sample recovery and inter-test reproducibility with very low standard deviations, as the studies from the Laboratoire départemental d'analyses de la Drôme clearly establish.
Concentration technology in Genevac systems has been developed with leading analytical laboratories.  This, with key technologies like Dri-Pure, ensure that samples are concentrated safely and rapidly. SampleGenie™ is a great aid to concentration because the evaporator only evaporates the solvent contained in the large flask, and not the solvent in the vial.  The system detects the end point of evaporation being when the solvent level enters the vial and, once validated, the method will concentrate the sample to the required level.  If a precise volume is required in the vial, then the sample must be over concentrated and then made up to the desired level with pure solvent.

For protein analysis, e.g. for nutritional studies, the EZ-2 with HCI resistance option is ideal.  Protein digests often require digestion with 6N HCl which is highly corrosive to traditional evaporation systems, however, HCl resistant Genevac systems are designed to withstand daily use of concentrated HCl.  

The Rocket has also found an interest application in some of the worlds best restaurants, those that specialise in molecular cuisine, where it is used to concentrate sauces, juices and other natural flavours for the chef to use.  Details of how the Rocket is used can be found in a new book; Modernist Cuisine - the Art and Science of Cooking. The Studio Kitchen blog has some interesting receipe ideas, and some of these are also on Kitchen Theory. 

Useful Papers:

  • An Improved Evaporative Sample Preparation Methodology for Determining Nitrofuran Antibiotic Residues in FoodstuffsKantonales Labor Zurich (KLZH), Zurich, Switzerland 
  • Analysis for pesticides: Method development to increase the recovery of volatile compounds by using EZ-2, a new generation of centrifugal evaporatorEnvironmental Protection Agency of Tuscany (ARPAT), Florence,  Italy        
  • Evaluation of the EZ-2 for Pesticide Analysis Laboratoire départemental d'analyses de la Drôme, Valence, France  
  • Evaluation of SampleGenie™ for Environmental AnalysisLeochimica Laboratories, Zoppola, Italy 
  • Evaluation of the Rocket and SampleGenie for Pesticide AnalysisLaboratoire départemental d'analyses de la Drôme, Valence, France

Natural Products Research

Natural products are researched for many reasons, from biodiversity preservation through flavour or fragrance research, to finding a cure for disease.  Whatever your reason, Genevac systems are used by researchers who are investigating the properties of the natural environment. 

For basic botanical and biological research, the miVac concentrator range are the mainstay for those extracting and purifying DNA or proteins for genome and proteome research.

Genevac systems are widely used by researchers seeking to extract functional molecules from natural sources.  A typical process would be to take a tissue (or micro-organism broth) sample and then perform a primary solvent extraction resulting in a large volume of crude extract.  The crude extract is often concentrated, for which the Rocket Evaporator is ideal, before being fractionated to isolate each component.  Fractionation may use a system such at the Sepbox, one, or two dimensional chromatography which produces many samples from one extract.  These samples need to be evaporated before storage or analysis and may require lyophilisation. Genevac HT series evaporators are used for this purpose. 

Useful Papers:

  • High Throughput Natural Product Discovery - a paper by Stephen Pickrahn, IFF 
  • Rapid Evaporation Processes to Enhance Natural Product Extraction - by Dr John Hester, Principal R&D Engineer – Natural Product Repository Supervisor, University of Mississippi

Post Purification Sample Handling

Depending on the process, and therefore the nature of the samples, then Genevac provides a number of solutions to facilitate post purification sample handling, including reformatting.

  • Normal Phase HPLC, SFC or Flash chromatography – removal of organic solvents is simple in a Genevac evaporator. Evaporation of Solvent Mixtures is safe when using Dri-Pure which eliminates the effects of bumping.
  • Reverse Phase HPLC– evaporation of water and acetonitrile (or methanol) is the principal application of many Genevac systems.  A multiple stage method has been developed to remove the organic solvent without freezing the water, remove the water, and then dry any remaining stubborn solvent.  Alternatively, the LyoSpeed fast lyopilisation method can be used in Genevac HT series evaporators.  Recent advances in condenser technology, in particular the high power -75°C cold trap available with the HT-8 or HT-12, have lead to significant advances in lyophilisation success rates.

Post Purification Handling following removal of purification solvents the sample typically needs to be reformatting from the fraction tubes or flask, into a small vial for compound storage. Genevac developed SampleGenie to enable a large volume to be dried (or lyophilised) directly into a small storage vial which eliminates the need to reformat samples from a flask or multiple tubes into a vial.

Depending on the number and nature of samples then one of several Genevac systems may be suitable – the EZ-2 and HT series are designed for working with smaller samples in plates, tubes and vials.  When working with large volumes in flasks – then the Rocket evaporator is the most suitable, taking up to 6 flasks.

Useful Papers: 
  • Drying HPLC Fractions - applications note 
  • Fast Lyophilisation for HPLC Fractions - Dr Induka Abeysena & Rob Darrington  
  • Enhanced LyoSpeed™ with a -75°C Condenser - Rob Darrington 
  • Integration for High Throughput HPLC Purification - Paul de Fraine, Syngenta & Dr Mike Jones 
  • Drying Solvent Mixtures - applications note 
  • Evaluation of the Rocket Evaporation System - paper by Christine Prosser et al., UCB
  • Automation of reverse phase HPLC fraction pooling, evaporation, and reformatting
Contact us if you are interested in any of the above papers

Oils, Fuels and Fats

Working with oils, fuels and fats can be difficult.  Whether extracting & recovering additives, evaluating lipid content of foods, characterising reclaimed cooking oils before reprocessing or conversion to biofuels, or investigating drillling test samples - oils can be difficult to dry in turn leading to problems with the analytical instrumentation.   

Extraction and separation techniques, be they basic dialysis, Dionex ASE or Counter Current Chromatography, all normally present the sample in a solution of organic solvent.  The sample typcially must be dried or concentrated before analysis.  Drying all the solvent can be difficult without using very high temperatures or other harsh regimens which may lead to loss of more volatile fractions within the oil.  For many such applications, researchers have found that the EZ-2 and the Rocket Evaporator have delivered significant enhancement to their recovery and results.  When working with larger solvent volumes, additional benefit is gained by way of  productivity savings when used with SampleGenie which enables large volumes to be concentrated or dried directly into a small vial.