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High-Throghput Circular Dichroism System (HTCD)

High-Throghput Circular Dichroism System (HTCD)

Automated high-throughput screening system

The high-throughput circular dichroism (HTCD) measurement system has been developed for use with either the J-1500 or  J-1700 CD spectropolarimeter. This system can accommodate two 96-well plates (up to 192 samples) with protection at controlled temperature prior to measurement.

System description

Measurements using predetermined parameters for automated spectral scanning  and/or temperature ramping measurement can be made with a Peltier thermostatted flow cell. In addition to CD, LD and absorbance data, fluorescence can be measured simultaneously (with optional accessory).  Small sample amounts are required and can be recovered back to the micro-plate after measurement. The post-measurement analysis program allows batch processing of data and includes spectral correlation for quality control, determination of melting parameters and secondary structure estimation.

  • ● Applications include peptides, proteins, nucleic acids, chiral organic components, monoclonal antibodies etc.
  • ● Micro-plate temperature control
  • ● Automated measurements with Spectra Manager-HTCD software; easily generated measurement sequences, including wavelength scan and temperature scan modes
  • ● Automated data processing

Product Specialist

Mats Grapne Kovalent

Mats Grapne

"More than 30 years experience in the field of HPLC, Spectroscopy and other analytical equipments. Contact me if you have questions or need a quotation"


The only CD instrument designed to explore the structure and stability of biomolecules by providing the maximum signal-to-noise under highly absorbing, low light intensity conditions of the far-UV spectral region.

The J-1000 Series Circular Dichroism spectrophotometers are specifically designed for high sensitivity measurements in the near- and far-UV regions, for scientists that need confidence in the data from characterization studies of biomolecule structure, function and stability under a wide variety of experimental conditions.

Unlike some detectors which only provide good signal-to-noise for low absorbing materials, the J-1000 Series circular dichroism spectrophotometers use high dynamic range detectors to obtain high quality spectra of samples with excellent signal-to-noise, especially for highly absorbing materials found in the far-UV.
  • Advanced Features of the J-1000 Series
    • High optical throughput
    • Double prism monochromator providing low stray light
    • Wide dynamic range PMT detector
    • Highly efficient nitrogen purge system
    • Digital signal processing Simultaneous
    • Multi-Probe: CD, LD, HT, DC, absorbance, fluorescence
  • Unique Benefits and Accessories
    • Compact benchtop design
    • Range of precise temperature control accessories
    • High-throughput automated CD
    • Automated titration and stopped-flow
    • Spectra Manager™ software for control and extensive data analysis
    • Flexible design allows field upgrades for different measurement capabilities as applications and budgets evolve
  • Versatility for a Wide Range of Applications 
    • Protein conformational studies
    • Quantitative analysis of pharmaceuticalsFormulation studies
    • Protein folding studies
    • DNA/RNA interactions
    • Enzyme kinetics
    • Purity testing of optically active substances
    • Natural products chemistry