NRS-4500 series Raman

For experienced spectroscopists and first-time users

NRS-4500 series Raman

For experienced spectroscopists and first-time users.

The NRS-4500 Series Confocal Raman Microscope combines a number of critical elements to make Raman spectroscopy accessible not only to experienced spectroscopists, but also to first-time users.

Brochure

System description

The standard Class 1 safety cabinet more commonly associated with high-end Raman systems.
The automatic XYZ stage is used for confocal imaging with X/Y spatial resolution to 1 µm (Z=1.5 µm). Spectra Manager™ Suite with the Imaging Analysis application is used to collect a three dimensional image of the sample which can be rotated and viewed from any angle. The image map is created using peak data corresponding to key functional groups and analysis of multiple peaks can be combined to create powerful data images.
The microscope has a completely rigid structure to prevent flexing and is not built around an optical microscope.he microscope has a completely rigid structure to prevent flexing and is not built around an optical microscope.
Switching between observation and measurement modes is completely automatic and can be done with the safety cabinet closed.

Product Specialist

Mats Grapne

"More than 30 years experience in the field of HPLC, Spectroscopy and other analytical equipments. Contact me if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.

08-473 3340

Standard Configuration
532/785nm Lasers with Matching Edge Filters

The NRS-4500 offers several standard configurations including the typical 633nm single laser or 532/785nm laser combination with matching notch or edge filters, with an option for a third laser which can be mounted internally or externally. Observation of the laser spot ensures perfect alignment of the target sample position and provides an indication of surface roughness. All laser wavelengths are selected in the software and once selected, the optical system (including the laser) is automatically aligned for optimal throughput and resolution. Four software selectable gratings control the spectral range and resolution from 8000 to 100 cm-1 (8000 to 50 cm-1 as an option). The grating direct drive system includes a rotary encoder to ensure excellent wavelength reproducibility ±0.2cm-1.

Fluorescence Rejection
457nm Laser and Patented Fluorescence Rejection Algorithm

JASCO has developed new and novel (patented) mechanisms to deal with sample fluorescence. As with other Raman systems, we can utilize laser wavelengths of 785 nm and up to 1064 nm, but we have recently incorporated a 457 nm laser that offers significantly higher Raman signal, improved spatial resolution and much lower fluorescence for many different sample types. Selecting a different excitation laser wavelength is only one of the ways the NRS-4500 minimizes fluorescence interference. The Fluorescence Rejection algorithm (patented) included in the Spectra Manager™ can effectively remove or minimize fluorescence regardless of the laser wavelength used either at the time of measurement or during post-processing.

Flexible Sampling Options

With a choice of refractive objectives, both micro and macro measurements are possible as well as options for long working distance objectives for heating/cooling stages and other sampling accessories. The NRS-4500 can be used with either a manual sample stage or the PC-controlled, automated XYZ confocal mapping stage. A fiber probe can be added for external measurement.
Powerful ‘UserAssist’ Control for Experienced Spectroscopists and New Users

The ‘UserAssist’ software aids the user in setting up the NRS-4500 for sample measurement; a simple sequence guide takes you through setup and optimization of measurement parameters with helpful advice and tips, such as a warning if you have the laser intensity set too high. When each of the parameters has been set, the NRS-4500 automatically selects the laser and matching notch filter, the grating for the appropriate resolution, focuses on the sample and then the spectral measurement is performed.
‘Simple Search’ Function

The new ‘Simple Search’ function is used with the automated XYZ stage. A new algorithm developed by JASCO (patent pending) analyzes the microscopic image and automatically selects measurement position(s) based on size, contrast and/or color of the target material. The user simply clicks the measurement button to execute spectral measurements of the desired sample positions.
Chemical Image Identification and Functional Groups Registry

To provide faster Raman image processing, the Imaging Analysis software includes a ‘Registry’ of possible functional groups or other relevant compound information based on peak height or area calculations. After peak height or area calculation is developed, it can be saved to the Registry for future analysis use. The registry includes the peak calculation information and a ‘label’ describing the relevant vibrational motion. Image maps can be developed from mapping data simply by clicking on the desired, registered calculation to obtain a false color image of the peak intensity data for the registered calculation.

Overview

The NRS Series for confocal Raman imaging microscopy includes three different optical configurations; the easy to use, yet powerful NRS-4500, with up to three laser wavelengths (from a wide range of visible to NIR) including the common dual laser 532/785nm configuration). The sophisticated NRS-5000 Series, with 300mm spectrograph, offering higher spectral and spatial resolution with the use of dual spatial filtration (DSF) and the NRS-7000 Series with 500mm spectrograph and poly-dispersive options. Both the NRS-5000 and NRS-7000 can be configured with up to 8 lasers (9 wavelengths). All models include Class 1 laser safety as standard and share the same comprehensive Spectra Manager™ Suite of measurement and micro-imaging software.

System Features NRS-4500/5000/7000 series

● High accuracy spectral resolution, with the use of rotary encoders for the grating drive mechanism to as little as 0.3cm-1 per pixel
● High spatial resolution with 0.1µm step, using the automated XYX stage (actual resolution depends on laser wavelength and objective magnification and N.A.)
● QRi (Quick Raman imaging) – a combination of EMCCD with an ultra-fast XYZ stage giving 0.1µm step resolution QRI increases the data acquisition speed by up to 50x compared with a conventional mapping stage and also offers a significant improvement in sensitivity. Available on all models
● SPRinTS (Software Programmable Raman Integration Speed) which uses Vertiscan to scan the laser through the objective to map samples that are likely to move using a conventional mapping stage, such as liquids and suspensions. Available on the NRS-5000 and NRS-7000 models only
● Long working distance stage and objectives, for larger samples and temperature control and high pressure accessories
● Optional fiber probe interface for external measurements
● Macro objective for measurement of powders and liquids
● Patented Fluorescence Rejection, an algorithm to reduce or eliminate fluorescence an enhance Raman measurement. Available on all models
● Spectra Manager™ Imaging Suite with KnowItAll®, for comprehensive measurement, analysis and reporting. The cross platform software includes the same feature for all NRS models with many options for chemometrics, spectral analysis, etc.

NRS-5000 series Raman

The NRS-5000 is a research grade instrument

NRS-5000 series Raman

The NRS-5000 is a research grade instrument

Combines the flexibility of multiple detectors and multiple laser sources to quickly change between measurement modes for fast data acquisition to reduce experimental time.

Brochure

System description

We developed a number of key technologies to improve measurement efficiency; these include DSF (Dual Spatial Filtration) which optimizes confocal focusing of the objective to reduce aberration and improve spatial resolution, SPRIntS for fast mapping without the necessity of moving the sample stage and SRI (Spatial Resolution Image) for simultaneously viewing the sample image and laser spot.We developed a number of key technologies to improve measurement efficiency; these include DSF (Dual Spatial Filtration) which optimizes confocal focusing of the objective to reduce aberration and improve spatial resolution, SPRIntS for fast mapping without the necessity of moving the sample stage and SRI (Spatial Resolution Image) for simultaneously viewing the sample image and laser spot.

A rigid honeycomb optical base is the foundation of the instrument ensuring alignment and stability. The laser(s), microscope, software-switched optics and a unique aberration-corrected polychromator with CCD detector provide an integrated package that is compact enough to fit on a laboratory bench. Operator safety (Class 1 laser safety) is maintained by a fully enclosed automated sample chamber door. This provides a 120 degree opening for the user to freely access the sample stage and objectives turret when setting up the experiment.

A high resolution color CCD viewing system with synchronized image capture and spectrum measurement enables accurate sample identification and positioning. The data is recorded in the Spectra Manager™ imaging application program and stored in the data file structure for easy reference. For application expansion, an automated multi-grating turret, 2 internally mounted detectors and a maximum of 8 lasers ranging from the UV through the NIR. All optical components are software controlled for maximum flexibility with minimum user interaction once the sample is loaded.

For application expansion, an automated multi-grating turret, 2 internally mounted detectors and a maximum of 8 lasers ranging from the UV through the NIR are capable of integration with the instrument system. All optical components are PC controlled for maximum flexibility with minimum user interaction.

● Exceptional wavenumber accuracy with a high-precision rotary-encoder direct drive mechanism
● Automated XYZ with joystick and mouse/keyboard controlSpectra Manager™ Suite
● Spectra Manager™ operating system for measurement and confocal imaging
● Low wavenumber measurement, close to the Rayleigh scatter(NRS-5600/7600)
● Auto-alignment of microscope laser introduction optics and Raman scattering light path
● Wavenumber calibration using an internal Ne lamp
● Unique Dual Spatial Filter (DSF) providing higher spatial resolution than conventional confocal optics, especially in the Z axis
● Patented Spatial Resolution Image (SRI) function for simultaneous observation of sample image, laser spot and aperture image

Product Specialist

Mats Grapne

"More than 30 years experience in the field of HPLC, Spectroscopy and other analytical equipments. Contact me if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.

08-473 3340

Options

The Objective turret can be mounted with a range of objective lenses matched to the measurement range and with a variety of magnification and working distances
Up to 8 lasers (9 wavelengths) each with a selected Edge or Notch filter
Trinocular for direct observation
Laser wavelengths from deep UV to 1064nm
Macro-Raman measurement unit for large liquid and solid samples
Fiber optic probesHeated and cryo-stages
Gas cells

NRS-5500

Maximum Resolution	1 cm^-1 0.4 cm^-1 (optional)
Measurement Range	50 to 8000 cm^-1

NRS-5600

Maximum Resolution	1 cm^-1 0.4 cm^-1 (optional)
Measurement Range	10 to 8000 cm^-1

Overview

System Features NRS-4500/5000/7000 series

● High accuracy spectral resolution, with the use of rotary encoders for the grating drive mechanism to as little as 0.3cm-1 per pixel
● High spatial resolution with 0.1µm step, using the automated XYX stage (actual resolution depends on laser wavelength and objective magnification and N.A.)
● QRi (Quick Raman imaging) – a combination of EMCCD with an ultra-fast XYZ stage giving 0.1µm step resolution QRI increases the data acquisition speed by up to 50x compared with a conventional mapping stage and also offers a significant improvement in sensitivity. Available on all models
● SPRinTS (Software Programmable Raman Integration Speed) which uses Vertiscan to scan the laser through the objective to map samples that are likely to move using a conventional mapping stage, such as liquids and suspensions. Available on the NRS-5000 and NRS-7000 models only
● Long working distance stage and objectives, for larger samples and temperature control and high pressure accessories
● Optional fiber probe interface for external measurements
● Macro objective for measurement of powders and liquids
● Patented Fluorescence Rejection, an algorithm to reduce or eliminate fluorescence an enhance Raman measurement. Available on all models
● Spectra Manager™ Imaging Suite with KnowItAll®, for comprehensive measurement, analysis and reporting. The cross platform software includes the same feature for all NRS models with many options for chemometrics, spectral analysis, etc.

NRS-7000 series Raman

The NRS-7000 Flagship models

NRS-7000 series Raman

The NRS-7000 Flagship models

The innovative instrument design ensures freedom from daily adjustments and alignment.

Brochure

System description

A specially designed honeycomb optical base plate is the foundation for the entire instrument guaranteeing alignment and stability. The laser(s), enclosed microscope, software-switched optics and a unique aberration-corrected polychromator with CCD detector provide an integrated package compact enough to fit on a laboratory bench.A specially designed honeycomb optical base plate is the foundation for the entire instrument guaranteeing alignment and stability. The laser(s), enclosed microscope, software-switched optics and a unique aberration-corrected polychromator with CCD detector provide an integrated package compact enough to fit on a laboratory bench.

With superb stability and effortless software controlled optics, the NRS Series Raman systems offer performance second to none, with no time-consuming realignment. Simply insert the sample, focus, and collect the spectrum. The integrated, automated XYZ mapping stage with auto-focusing option allows full PC control. Complete operator safety is maintained by the fully enclosed automated sample chamber door which provides a 120 degree opening to allow full microscope access.

All NRS Series Raman instruments include a color CCD sample viewing system with image capture capability. For additional flexibility, a trinocular microscope attachment can be added for direct binocular viewing. Utilizing the same basic optical system, we’ve designed a family of micro-Raman spectrometers that offer a range of capabilities from simple, single laser, single grating instruments to advanced research grade systems with low wave number measurement, wavelength extension from the deep UV to NIR, and the ability to use or add up to 6 lasers.

For application expansion, an automated multi-grating turret, 2 internally mounted detectors and a maximum of 8 lasers ranging from the UV through the NIR are capable of integration with the instrument system. All optical components are PC controlled for maximum flexibility with minimum user interaction.

● Research-grade model assuring high spectral quality
● Exceptional wavenumber accuracy with a high-precision rotary-encoder direct drive mechanism
● Low wavenumber measurement (NRS-5600/7600)
● Auto-alignment of microscope laser introduction optics and Raman scattering light path
● Wavenumber calibration using an internal Ne lamp
● Unique Dual Spatial Filter (DSF) for higher spatial resolution than conventional confocal optics
● Patented Spatial Resolution Image (SRI) function for simultaneous observation of sample image, laser spot and aperture image
● Full range of options including macro-Raman measurement unit and fiber optic probes

Product Specialist

Mats Grapne

"More than 30 years experience in the field of HPLC, Spectroscopy and other analytical equipments. Contact me if you have questions or need a quotation"

This email address is being protected from spambots. You need JavaScript enabled to view it.

08-473 3340

Overview

NRS-7500

Maximum Resolution	0.7 cm -1/ 0.3 cm -1 (optional)
Measurement Range	50 to 8000 cm -1

NRS-7600

Maximum Resolution	0.7 cm -1/ 0.3 cm -1 (optional)
Measurement Range	5 to 8000 cm -1

System Features NRS-4500/5000/7000 series

● High accuracy spectral resolution, with the use of rotary encoders for the grating drive mechanism to as little as 0.3cm-1 per pixel
● High spatial resolution with 0.1µm step, using the automated XYX stage (actual resolution depends on laser wavelength and objective magnification and N.A.)
● QRi (Quick Raman imaging) – a combination of EMCCD with an ultra-fast XYZ stage giving 0.1µm step resolution QRI increases the data acquisition speed by up to 50x compared with a conventional mapping stage and also offers a significant improvement in sensitivity. Available on all models
● SPRinTS (Software Programmable Raman Integration Speed) which uses Vertiscan to scan the laser through the objective to map samples that are likely to move using a conventional mapping stage, such as liquids and suspensions. Available on the NRS-5000 and NRS-7000 models only
● Long working distance stage and objectives, for larger samples and temperature control and high pressure accessories
● Optional fiber probe interface for external measurements
● Macro objective for measurement of powders and liquids
● Patented Fluorescence Rejection, an algorithm to reduce or eliminate fluorescence an enhance Raman measurement. Available on all models
● Spectra Manager™ Imaging Suite with KnowItAll®, for comprehensive measurement, analysis and reporting. The cross platform software includes the same feature for all NRS models with many options for chemometrics, spectral analysis, etc.

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