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The CambTEK Rapid Extraction System (RES)

Fully Automated Sample Preparation instrument for rapid extraction of solid dose forms, gels, and liquids.

RES-CG and RES-Sonics: Fully Automated Sample Preparation instrument for rapid extraction of solid dose forms, gels, and liquids.

The RES uses patented turbulent flow technology, with optional ultasonication or crush and grind mechanical force to accelerate sample preparation extractions.
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Fully automated and aqurate sample preparation

Samples are quickly extracted, filtered, and diluted, ahead of analysis. The RES is suitable for testing content uniformity (CU), impurity (imps), composite and bulk assay, ICH stability assay, blend and granulation uniformity, and other applications requiring a liquid extracted sample preparation. From analytical R&D through to QA/QC laboratories, the RES improves quality of data, productivity, compliance, process standardization, and simplicity, whilst also delivering health & safety, environmental, and economic benefits.

  • ● Full automation of all steps from formulation to diluted and filtered samples in 2 ml vials
  • ● Gravemetric confirmation of all solvent dispensed volumes by build in balances
  • ● Full tracability via barcode on all used consumables
  • ● Unbeatable reproducability independent of system user

Product Specialist

Mats Grapne Kovalent

Mats Grapne

"More than 30 years experience in the field of HPLC, Spectroscopy and other analytical equipments. Contact me if you have questions or need a quotation"

mats.grapne@kovalent.se

08-473 33 40

Ease of use

Flow Cell

Step one:
Load the sample into the FlowCell

Load the puck onto the Carosel

Step four:
Load the puck onto the Carosel

 

Puck for Sample, Filter and Dilution vial

Step two:
Load the FlowCell into the Puck

Process the sample

Step five:
Process the sample

 

Scan the barcode

Step three:
Scan the barcode and input the data

Result out

Step six:
Result out

CambTEK RES

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RES Technology

The selected extraction eluent is dispensed to ASTM Class A dispensing accuracy, with gravimetric verification of solvent arrival. The extraction eluent is then circulated around the closed loop system, the turbulent flow quickly extracting the sample contained within the FlowCell.The selected extraction eluent is dispensed to ASTM Class A dispensing accuracy, with gravimetric verification of solvent arrival. The extraction eluent is then circulated around the closed loop system, the turbulent flow quickly extracting the sample contained within the FlowCell.


An aliquot of solute is filtered and dispensed into a septa-sealed 22 mL primary vial. If required, the filtrate is then automatically diluted to ASTM Class A dispensing accuracy, to achieve the required concentration from 1:1 to 1:100000 dilution range.


After mixing to achieve homogeneity, a volume can be automatically dispensed into a septa-sealed 2 mL HPLC vial, or directly injected into your analyser.

 

  • Quality control

    Designed to highest standards to ensure regulatory and quality compliance of data integrity, validity, and repeatability.

  • Productivity

    The unique SPEx technologies, Forced Jet Mixing and High Frequency Pulverizing, in conjunction with the extraction pouch, simplify and speedup laboratory productivity

  • Reproducible Processes

    Semi automated sample preparation for improved repeatability over traditional manual techniques

  • Health & Safety

    Semi automated sample preparation and enclosed system reduces user exposure to harmful substances

  • Process Standardization

    Platform technology aids compliance and consistent results independent of user proficiency or laboratory location

  • Versatility

    Processes a wide range of sample types in both single sample and bulk assay, including more challenging formulations such HPMC, PEG, PEO and laser-drilled.

  • Flexibility

    provides sample preparation front-end to any dosage form analytical workflow

  • Economic

    Increased productivity, no washing, no glassware, affordable technology, significantly reduce sample preparation costs

  • Ease of Use

    Intuitive instrument and software use, and error prevention with barcoded consumables

  • Reliability

    Robust design and high component specification delivers minimal downtime and maximum reliability.

RES Consumables

The patented technology and features of the FlowCell aid rapid extraction. The labyrinth acts as an effective powder trap, allowing powders, gels and semi-solids to be constrained without loss prior to testing. The optional RES ‘Flowtainer’ insert allows liquids and low-viscosity gels to be processed within the same workflow.

The consumable workflow and sanitary design minimizes cleaning requirements.

11 types of Millipore filters are available, with an extensive selection of pre-filters, pore sizes, and membrane materials, suitable for a wide range of applications.
Included are two borosilicate Chromacol vials, manufactured to meet international standards.

All components carry a barcode to uniquely identify the consumable ‘family’, which allows for sample tracking, instrument method and safety error-checking, and ultimately greater compliance. After the sample has been prepared, any of the barcodes from that particular family can be scanned to access the related post-extraction sample report.

Consumable pack contents

● 1 × FlowCell: Barcoded 9 cm3 or 14 cm3 sample capacity. Patented technology for accelerated extraction.

● 1 × 20 mL vial: Barcoded primary sample vial for collection of filtrate and dilution. Screw cap & septa.

● 1 × 2 mL vial: Barcoded amber HPLC vial, crimp top & septa.

● 1 × Filter: Choice of barcoded filter - see below for the full selection.